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Database: UniProt
Entry: H3D3M6_TETNG
LinkDB: H3D3M6_TETNG
Original site: H3D3M6_TETNG 
ID   H3D3M6_TETNG            Unreviewed;      2678 AA.
AC   H3D3M6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 2 {ECO:0000313|Ensembl:ENSTNIP00000015114};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000015114, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000015114}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000015114}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   STRING; 99883.ENSTNIP00000015114; -.
DR   Ensembl; ENSTNIT00000015318; ENSTNIP00000015114; ENSTNIG00000012150.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000156039; -.
DR   InParanoid; H3D3M6; -.
DR   OMA; ENQVKGG; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2201   2234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2246   2265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2336   2359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2379   2401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2501   2524       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      379    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1902   1922       {ECO:0000256|SAM:Coils}.
FT   COILED     2632   2663       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2678 AA;  306176 MW;  B965EB22A7FDD0C4 CRC64;
     MSEHRSSFLH IGDIVSLYAE GSVNGFISTL GLVDDRCVVQ PDAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QFWKAKQGKQ GNSNTQGDLF KKLQHAAELE QKQNESENKK LLGEVVKYSN
     VIQLLHIKSN KFLTVNKRLP ALLEKNAMRV SLDPAGNEGS WFYIQPFWKL RSEGDNVVVG
     DKVVLMPVNA GQPLHASNIE LLDNPGCKEV NAVNCNTSWK ITLFMKFSDY KEDVLKGGDV
     VRLFHAEQEK FLTCDEHRRQ QHVFLRTTLR QSATSATSSK ALWEVEVVHY DPCRGGAGQW
     NSLFRFKHLA TGNYLAAEVN PEFKDNTTAP RGENETDVVF SKRKHQAAEK ITFTLVSVPH
     GNDIASLFEL DATTLQRADC LVPRNSYVRL RHLCTNTWVT STNVPIDTEE ERPVMLKIGT
     CPAKEDKEAF AIVSVPLSEV RDLDFANDAS KVLESTVRKL QYGTITQNER RFVTKLLEDL
     VFFVCVVPNN GQDVLSVVTS TPNRERQKLM REQNILAQIF GILKAPFTDQ GDGPILRLED
     LGDQRYAHFK YMLRLCYRVL RHSQQDYRKN QEYIAKKFTI MQSQIGYEIL AEDTITALLH
     NNRKLLEKHI TAREIETFVN LLRRNREPRF LDYLSDLCVS NKTAIPVTQE LICKFMLNPT
     NADILIQTKL IANTETTLES SLLVWLYWID SHKEPHGKSI RHLAQDAKGI HKMDVDIITY
     YRYQLNLFAK MCLDRQYLAI NQVSCQLPVD LILRCMFDDC LPYNLRASFC RLMLHMHVDR
     DPQESVVPVR YARLWTEIPS KITIHEFEYE STDTSREEMK RKFAPTMEFV EEYLRDVVSQ
     PFPFGDKDKN ELTLEVVNLA RNLVYFGFYS FSELLRLTRT LLAILDIVQH PLSLINKLNK
     SPEAGNNVLR TIHGVGEMMT QMVMSRGVPH SLTDTPPSLR YGKGYFFSDN EDVMVMDTKL
     KIIEILQFIL SVRLDYRITY LLSIYKKEFG DNSIVENSMA EFPPMSPMLL FTPASEPDID
     EITTKAETMF AGSSELSAVE LDDEGGRTFL RVLIHLIMQE YPPLVSGSLQ LLFKHFSQRA
     EVLQAFKQVQ LLVSEQDVEN YKQIKTDLDQ LRLTVEKSEL WVEKSGAYNG EDLAVRQGKE
     PNELSLQEGV LSPVQDGDNK PQIDSNKANN YKIVKEILLR LSKLCYPSKK SRVQQQRLLK
     NMGAHTVVLD LLQIPYEKSD EKMNEIMTLA HTFLQNFCRG NPQNQVLLHK HLNLFLTPGL
     LEAETMRHIF MNNYQLCNEI SDRVVHHFVH CIETHGKHVQ YLKFLETIVK ADGKYVKKCQ
     DKVMTELVNG GEDVLVFYND RSSFPVLLQM MGSERERTDE DGALAYHNTL VELLAACTEG
     KNVYTELKCN SLLPLDDIVR VVTDIHCVPE VKTAYVNFVN HCYVDTEVEM KEIYTSNHIW
     KLFDNFLVDM SSACNTTTER NHADSALEKY VTETVMAIVK GFFSSPFSVN HANLQTNQSI
     FIKLLQSSFR IYNCTWLSAP QKANIESCIK TLADVAKARA IAIPVDLDSQ VNTLSLKVHS
     TMVQRAAKDW RTSARSRPRK EPLGGPDYRN IIEKLQGVVS LLEEQFSPKV QAEFSVLVDV
     LHSPELLFPE AAQLCESGAF MSKLIKHTKK LMDKEEKLCI KILQTLREML DEKKCIQESV
     STWRLMKIMR EGKADRQNTE RMTAKTAEVG GSPGMQSHVR SHVSRRGKKS GQRLQDEGLA
     RSVVCWVYEK PGQGVRLRNS LQWLSQCHIV SQQTASCSRQ TSEGERPRAP FKLHSPGWFF
     SRCLRAELIL HNLGKKRGNV ESNMVLFGIK MHRKESGLHM RDDMRGQLKE ASSVTSKAFS
     AFRKELDPDL DGLSQNSDIT AAEEGLEETN MSPAIAIMKP ILRFLQLLCE NHNSELQNFL
     RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINES NVDLIRQTLE TITEYCQGPC
     HENQTCIAKH ESNGIDIIIA LIVNPINPLG KNRLDLVLEL KNNASKLLLA IMESRHDSEN
     AEKILYKMRP NELVDVMKEA YTQGLQSEEE DDGVGDQIKP RDVGHNIYIL AHQLARHSKV
     LQQSLKPGSG SPFDPDNEKD DALHYYANHT AQIEIVRRDR TMEQIVFPVP NICEYLTEES
     MVRVFTTTER DDQGSKVNDF FQQFDNLYNE MRWQKKIRKN IALFWFSRNI SLWGSISFYL
     ACLVNIAVAV FYPFGDDGDE GTLSPFWNIL LWVALGVFSI LLPVLPKPQG ILFFLVSLIL
     RSIYTLGLGP ALLLLGTSNL FNKLVFLVSF VGNQGTFTRG YKAVVMDMLF IYHMSYAIIC
     VLGLLVHEFF YSFLLFDLVI REETLLNVIK SVTRNGRSII LTAILALFLV YFFSIIGFLF
     LKDDFRMEVD RLPAPGLNYF LNQPYQSQIR ISQKKKKKSP NFPCVNRADE DDGMERVCDT
     LFMCIITVLN QGLRNGGGVG DILRRPSKAE PLFAARVVYD LLFFFVVIII VLNLIFGVII
     DTFADLRSEK QRKEEILKTT CFICGLERDK FDNKTVTFEE HIKSEHNMWH YLYFLVLVRV
     KDPTEYTGPE SYVAQMIAEK NLEWFPRMRA MSLVSNEGEG EQNEMRCLQE KLSDTVTLVA
     QLSAQLSELK EQMTEQRKNK QRLGFLGPSQ VNHHIPTH
//
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