ID H3D4R1_TETNG Unreviewed; 881 AA.
AC H3D4R1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Rap guanine nucleotide exchange factor (GEF) 3 {ECO:0000313|Ensembl:ENSTNIP00000015500.1};
GN Name=RAPGEF3 {ECO:0000313|Ensembl:ENSTNIP00000015500.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000015500.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000015500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3D4R1; -.
DR STRING; 99883.ENSTNIP00000015500; -.
DR Ensembl; ENSTNIT00000015706.1; ENSTNIP00000015500.1; ENSTNIG00000012531.1.
DR GeneTree; ENSGT00940000159931; -.
DR HOGENOM; CLU_006829_1_0_1; -.
DR InParanoid; H3D4R1; -.
DR OMA; QVFPDRC; -.
DR TreeFam; TF313184; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF24; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 73..145
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 207..308
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 346..481
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 620..848
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 881 AA; 100297 MW; 37766C4208ECF4DF CRC64;
LGRMEMHLFR SYRYRVFPDR LSVETPTIRG ISWTPLPESL DPKCSMKQFL SDRIVKAARS
VYSVMVEKNP GLIRDRKHHL KTYRQCCSGK ELVDWLLKQS ECLQSRSQVV GMWQVLVDEG
ILLHDKVKQE LNFHDKDAQF YRFRDDGCSP NHVTNEREAE EELQEGLSLL AQLGPDALLT
MILRKCPSQR SAEDLEVIYE ELLHVKAAAH LSTSVRKELA AVLLFESHAK AGTVLFSQGD
KGTSWYIIWK GSVNVITHGK GLVTTLHEGE DFGQLALLND APRAATIILR EDNCHFLRVD
KQDFIRILKD VEANTVRLEE HGKSVLVLEK SSDTAAADRS RQQLQVRYTV MSGTPEKILE
HLLETVKLDS SGSDAVDACV SDFLLTHRVF MSSSQLCSAL QLQYPDAEPS EGSDQDKASY
VLATKQRVVK LVCHWVALYG LLLKDDPVAL DFLEKLKKEV GADFRLSSIV KEQFRERRRT
RILENGYQSL SRRQQNQNFD WFSHCEEPVG RLQPIRARDK VLWEISRPDG KALALMLPVD
ASVQDVISAV GKPGGDQVLV RMNSAGERAE LKLDAAAVFT ALGVNERLFL CSSSQVEKLF
PLKEQQGPER GTADILEQMS SKDVAAELTN YDWELFTAMH EVELIYYVFG RHKFPGAVTA
NLERFVRRFN EVQHWVATDL CLCTDLVKRA LLLKKFIKIA AVLKEQKNLN SFFAVMFGLS
NSAVRRLHKT WERIPSKTKR VYCSYERLMD PSRNHRAYRL TVAKLGPPYI PLMPLLLKDM
TFINEGNANH VDKLVNFEKM RLMARTVKVV RGCRSQPYTA PSSPQRSLAD RVFLEGPATR
MSTCSEHGLL RSPGNIRHYI QNLKVIDNQR QLTQLSRTLE C
//
