ID   H3D685_TETNG            Unreviewed;       818 AA.
AC   H3D685;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Prominin 1a {ECO:0000313|Ensembl:ENSTNIP00000016025.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000016025.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000016025.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC       {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the prominin family.
CC       {ECO:0000256|ARBA:ARBA00006058}.
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DR   AlphaFoldDB; H3D685; -.
DR   Ensembl; ENSTNIT00000016236.1; ENSTNIP00000016025.1; ENSTNIG00000013046.1.
DR   GeneTree; ENSGT00530000063586; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008795; Prominin.
DR   PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR   PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR   Pfam; PF05478; Prominin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        75..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        404..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        454..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        766..785
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   818 AA;  91507 MW;  9C8C88B94E2C5E68 CRC64;
     VPAGVYETVA HYEPGPIGIL FQLVQGFLHI VQPNAFPQED ILRKFMLKHH IIEKKTEYQK
     PENIVLTLQA IYYEIGFLVC AAVGLLFAIL MPVVGLFFCM CRCCDNCGGE MHQRQRKNAD
     CRRGLLGTLL FSTSLVITIG VLCAYAANQN LSSQVKNIRR YVNSNMRDLH TFANDTPMQI
     DYLLSQYATA KNKVIYDLNN IGPLLGGRIH DQLDKEVHAA LDGALNMAAA MRETKEALEN
     ASMGLEVLQE GTGKLGFNLS LVRTSINRTL SDPGCHDEES DATTAQLCRN IRQSLSQLQI
     SANFTRLPNV NVQLAKMKDV LKMDLSTIVQ RGFSSFNDTP HMVTEQTRSV VENVQSLMDD
     IGRNISSFSK IFPVQSCLTN FTIFISHVHA KIEDHYPEID KMDFYRWIGC ITLCCMVVLV
     LAFNYLGLLC GTLGYDKHAS PTTRGCISNT GGTMLIAGVG ISFIFSWVLM GLVTIIFLAG
     GNMEKLVCEP FHTKEVFKVV DTPYLVHPDW RNFIPGYLYN DPDMDLTAES FYSTCKDNKG
     IYSALRLDKV FNISSFLNTT VFTKDVVARL NNVKIDLRGI ILLEAEGKQN LLDFSEAGLL
     EINYADYLEE VNKGVTAVDL LSFARELEAQ TDLMPRSGLQ MALKGHAGTL RQIHSQQILP
     MEQAMSALNQ SMRYLERTAS DLPNKVLAVI EAIEAAQYVI SHNATHLINR ETAKFTATIV
     GYFNQYIEWV KTALAMEVAP CKPFSNMVDT AEIITCSFLV DSMNTFWMGL GCSTLLLLPS
     IILAVKLAKF YRRMETEDVY DDIETIPMKT DCVNNTSH
//