ID H3D6J3_TETNG Unreviewed; 1391 AA.
AC H3D6J3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000016133.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000016133.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR STRING; 99883.ENSTNIP00000016133; -.
DR Ensembl; ENSTNIT00000016344.1; ENSTNIP00000016133.1; ENSTNIG00000013151.1.
DR GeneTree; ENSGT00930000151028; -.
DR HOGENOM; CLU_000487_3_0_1; -.
DR InParanoid; H3D6J3; -.
DR OMA; AVCPPYN; -.
DR TreeFam; TF103054; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02736; RNAP_III_Rpc1_C; 1.
DR CDD; cd02583; RNAP_III_RPC1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR035698; RNAP_III_Rpc1_C.
DR InterPro; IPR035697; RNAP_III_RPC1_N.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 250..555
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1391 AA; 155803 MW; 8B712CE8C587A066 CRC64;
MVKEQFRETD VAQKISHICF GMKSAEQMRQ QAHIQVVSKN LYSQDTAHTP LAYGVLDHRM
GTSEKDRPCL TCGKTLADCL GHYGYLDLEL PCFHIGYFKA IIGILQMICK TCSSIMLTKE
EKLQFMDQLK RPTLTYLHKR GLKKKISEKC RKRTICLNCS AFNALGPVKK CGLLKIIHEK
YKTTKKVVDP FVSEFLQSFD IAIEHNKVLE PLLSRAQENL NPLVVLNLFK RISREDIPLL
LMNPEAGIPA DLILTRLLVP PLCIRPSVVS DLKSGTNEDD LTMKLTEIIF LNDVIKKHRM
TGAKTQMIME DWDFLQLQCA LYINSELSGI PLNMAPKKWT RGFVQRLKGK QGRFRGNLSG
KRVDFSGRTV ISPDPNLRID EVAVPVHVAK ILTYPERVNK ANLELMRKLV RNGPEVHPGA
NFIQNRYNQI KRFLKYGNRE KIAQELRYGD IVERHMIDGD IVLFNRQPSL HKLSIMAHIA
RVKPHRTFRF NECVCTPYNA DFDGDEMNLH LPQTEEAKAE ALILMGTKAN LVTPRNGEPL
IAAIQDFLTG AYLLTLKDTF FDRSKACQIV ASILVGKDEK VRISFPRPAI MKPMALWTGK
QIFSVILKPS KDCPVNANLK TKGKQYCGKG EDLCHNDSFV VIHNSELMCG SMDKGTLGSG
SKNNIFYILL RDWGQLEAAN AMSRLARLAP VYLSNRGFSI GIGDVTPGQG LLKAKHDLLD
DGYTKCDEYI EALQTGKLQQ QPGCTAEETL EALILRELSV IRDRAGSACL RELDKSNSPL
TMALCGSKGS FINISQMIAC VGQQAISGSR VPDGFENRSL PHFEKHSKLP AAKGFVANSF
YSGLTPTEFF FHTMAGREGL VDTAVKTAET GYMQRRLVKS LEDLCSQYDL TVRSSTGDII
QFIYGGDGLD PAAMEGKDEP LEFKRVLDNI RAVYACSDEP ALSQNELVLT ADAIMKRTDF
LCCRDSFLEE IKKFVKSFSE RIKKTRDKYG INDNGTSEPK VLYQLDRITP TQLEKFLETC
RDKYMRAQME PGSAVGALCA QSIGEPGTQM TLKTFHFAGV ASMNITLGVP RIKEIINASK
NISTPIITAH LDVEDDADFA RLVKGRIEKT LLGEISEYIE EVFLPDDCFI LVKLSLERIR
LLRLEVNAET VRYSICMSKL RVKPGDAVHG EAVVCVSPRE NSKSSMYYVL QSLKEELPKV
VVQGIPEVSR AVIHIDEQSG RNKYKLLVEG DNMRAVMATH GVKGSRTTSN NTYEVEKTLG
IEAARSTIIN EIQYTMVNHG MSIDRRHVML LADLMSYKGE ILGITRFGLA KMKESVLMLA
SFEKTADHLF DAAYFGQKDS VCGVSECIIM GIPMNIGTGL FKLLHKADKD PSPAKRPLLF
DNAAFHIPLN T
//
