ID H3D774_TETNG Unreviewed; 2421 AA.
AC H3D774;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Cullin 7 {ECO:0000313|Ensembl:ENSTNIP00000016365.1};
GN Name=CUL7 {ECO:0000313|Ensembl:ENSTNIP00000016365.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000016365.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000016365.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR STRING; 99883.ENSTNIP00000016365; -.
DR Ensembl; ENSTNIT00000016578.1; ENSTNIP00000016365.1; ENSTNIG00000013374.1.
DR GeneTree; ENSGT00940000153954; -.
DR HOGENOM; CLU_001067_0_0_1; -.
DR InParanoid; H3D774; -.
DR OMA; KPWKPNH; -.
DR TreeFam; TF101154; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd20347; BRcat_RBR_CUL9; 1.
DR CDD; cd20359; Rcat_RBR_CUL9; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR047561; BRcat_RBR_CUL9.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047560; Rcat_RBR_CUL9.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22771:SF4; CULLIN-9; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1149..1329
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1557..1804
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT DOMAIN 2051..2269
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 2222..2265
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 84..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1442..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1939..1964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2421 AA; 272986 MW; 519FD32F8B6F2C0B CRC64;
MVGERRNGNL LVQLGPSLQA YPEELIRQRR NQDGQMEYLI RWCLVVINDG SGSGPGEAKP
ENILMWMSME DVYANCPTLL GKRKTDAQRP LQQEQNQRSS DEFPADVTFD EVELSDMKED
VKNLVRRARK QMMKKSDFSI SITHTIHVLS AYASIGSLVG VFKETGALNL LMELLCNKET
QRRSAGKMLR ALASHDAGSR AYVLLSLSQQ DGIEQHMDFD NRFTLLELFA ETTSSEEHGI
SFEGIHLPQI PGKLLFSLVK RYLCVTSLMD KLNTAAVDSL ADRQDSPAPA AFCGPTQPTE
QLRLQREFDF TMAMANLISE LVRVMGWDRN RQPPETPASC PGGSIFQPRF CASPIVLIST
SVAATPRPRR QRRSLKTRAD FVTRSAYVEY VQDNLKSGMS VRMLEDYEEV SAGDEGEFRY
SNDGTPPVQV YWNSLSRTYW VHWHMVEILG GGSGGSQADK EMQENVPTLT DTVKPQRRPP
GGLYSLPYLS EGLQAEPPAL SRAEWWEILF FIKKLETKQQ QEVNSILQQN LDEHEVELDD
SSLIALSVPG DVAKKLLHFL KQKLPSSCLS DLLCSHAFSK HYLRRGGGSL EDEELLGEEA
GGEPCWQNSN TEAGFFPAKL SENSTSSLSA VASSSSVMGS VSKKVRKEPP PDSSCSSQDV
ENELPSEDDV QTSAAFNNPR VQGKKTVLEK LGEVVDVLKK GTSASDQDMQ LVAVLFMTRL
LKEKGAQEKN SMRNDSAQTV RDKMLKLLVD LLSSSSKDLV ISTLRLTHLL MLKYDWRVSF
ATEGGVKSIL SCMQEFSSVT QVQQLALAAM KVITGASKYD FRSIGSSLPL SESGTQMMLE
IFASIGSATP EGSRGLLAAI PAAVDLMLKT KGCTLSVRNG LLLIIMLISN HKSLAEQLVA
ADVAAILKKC LTLSRAESML AIIALNHISM VHKLESNGAL HLPSTVMNQD MKLQMLLVSL
KELTATKEVI QTLEQLLCEE SEGESLFVGV FDQVTHSRDT YQDLVRLMEQ HRSERAIQLS
ILRILNKFLD NFEEDELPWH ESIEPCLSSM TAFISDREVL QQFIRFLYRL ASLNKDYAVV
MCRVGTKEAL VKALDKHGTN LLLVTELRDV ISDCEKYASL YKKMTTSVLA GCIQMVLGQI
EEHRRSHQPI NIPFFDVFLR NLCQGSSVEL TEDKCWEKVD VSSNHHRANK LTDKNPKTYW
ESNGCTGSHF INIYMHKGVV IRRQLAILVA SEDSSYMPAR ILVLGGDDPS NINTELNTVN
VSPTASRVVL LENMTRFWSI IQIRVKRCQQ GGIDTRVHGF EVLGPKPTFW PVFKEQLCCR
TYLFYSTKAH TWCQEVMEDK MQLLQLFNKL NSALRHEQMF AVRFLPDAEA AEALGRTCWE
ALITPIVHSI TLSESSACSP LSWLLSEYLD NSESPRRCKS RAAIFNSRVR RLTHLLVHVD
TSQADEEELK PPTKSNGKET KNAASPSSSS LAKPRGKSSS SITGIAHCWQ GVVQWQVKKF
LELSCNLPDF VERYRSLYLR LKNAMEELFG QQTAFVLALR QGFSAALLQL SILQAMHVSE
RFAQYIDQII QSSGMAYGSM EHLQQFLEPI LFLSGLELAN TFEHFYRYYL GDRLLARGNV
WLETTVVDQI GSCFPSRFPQ QMLKNLSESA ELQQEFHLYR LQRLDRRLQE QDQMMEDWAG
SEEEVEVQVL VLSPRYWAVS ALCYLDEPAK HFPAELSSYL DQFTQFYSHS QYMYSLSHSK
PRRLQWTWLG HAELQLGCTT LHVSTLQMFI LLQFNKLQEV RVDALLEVSG VPAAMLLHAL
QPLIDKGGPL TCSHPDSLTQ GRVLQLRQQA ASDGVPACVS LLPKQTYLNV NEDAAGTLER
KRNYIYCLIV HILKQEKEMH IDNLVFKVLE SCQKQEAMRS PAGGRFSCTT SDVLSCIMHV
ISRGCARRNE ENPHIVEFLP EDPPTPQKGQ AQFSFSPADV RKDPSNGVAD ISAVLMSMGR
TMTQDDVRQL MQRTVQQVSE TLSLDQDWAE HLLIHCKWNT DLLVQRYTDD AESLIMAAGL
KFRNPQPSSS PAVTCPVCLS PQNPVSEPVQ SLICMHYCCR LCWQEYLTSR IEQNLVMNCN
CPIPDCQAQP TSRFFLEILT EKDTIAKYEN TLLRGYVECC SNLTWCTNPQ GCDQILCKEN
MGSMGTCSKC GWSSCFSCNF PEAHYPASCS HMSQWMDDGG YYEGMTMEAQ SKHLAKLISK
RCPSCQAQIE KNEGCLHMTC AKCNHGFCWR CLKPWKPTHK DYYNCSAMVS KAARQEKKFQ
DYNSRCTFHH QAKDFAINLE NKVSSINEAL QMKSLTFVID ACKALARARK VLAYSCVYTY
YNQETEKMDV IEQQTEALDL HTNTLQILLE ETLLQCTDLA SCVRLLKKEH LNTGLELIRR
IQERLMAILQ HSTRDFRVGY Q
//
