ID H3DBA1_TETNG Unreviewed; 489 AA.
AC H3DBA1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) {ECO:0000313|Ensembl:ENSTNIP00000017793.1};
GN Name=H6PD {ECO:0000313|Ensembl:ENSTNIP00000017793.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017793.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017793.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC {ECO:0000256|ARBA:ARBA00004959}.
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DR AlphaFoldDB; H3DBA1; -.
DR STRING; 99883.ENSTNIP00000017793; -.
DR Ensembl; ENSTNIT00000018017.1; ENSTNIP00000017793.1; ENSTNIG00000014756.1.
DR GeneTree; ENSGT00530000063435; -.
DR HOGENOM; CLU_013524_2_0_1; -.
DR InParanoid; H3DBA1; -.
DR OMA; YCPQSGT; -.
DR TreeFam; TF354247; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR019796; G6P_DH_AS.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23429:SF7; GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 15..197
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 202..474
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT BINDING 194
FT /ligand="substrate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10005"
SQ SEQUENCE 489 AA; 55194 MW; 53ECDF51DEED672A CRC64;
EDRKDGQAPG HVSVVVVGGT GDLAKKYLWQ GFFSLYADKV SSGNTFSFVC GGLSPPDRAT
PVFFEILKGL SCWKAVSEER CALLKEQFLR LSQYRQLKTL EQYQDLNKHI EQELQQEGMR
EAGRLFYLSV PAFAYADVAD KINSSCRPKS GAWLRVVLEK PFGHDLRSAQ VLTSQLESSL
KDEEMYRIDH YLGKQAVAKI LPFRMDNSGF LDPIWNKNHI ERVEVVVKET LDVKGRISYY
DQYGVIRDML QNHMTEVMTL LTMRLPSSRD SSDEVLRNQL QVLGSLQPLG RRQAVVGQYQ
SYRSEVQQEL NKTREHVSLT PTFAAVLAFS GEARYDGVPI LLVSGKKLDE RVGYARILFK
NDVLCLQNHP GVHCKPKQIV FHFGHGALGH PAILVSKNLF KPLLKDAEQR EAYSELISHI
FAGRKNNFIR AESLLASWGL WTPLLSGLAD TFPRIYPGGA ENGASLDVYV KGNELRFYTE
VTIINSDPM
//
