ID H3DBQ4_TETNG Unreviewed; 1914 AA.
AC H3DBQ4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Myosin IXb {ECO:0000313|Ensembl:ENSTNIP00000017947.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017947.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSTNIT00000018171.1; ENSTNIP00000017947.1; ENSTNIG00000014903.1.
DR GeneTree; ENSGT00940000156845; -.
DR HOGENOM; CLU_000192_2_2_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 2.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR046987; Myo9.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46184:SF2; UNCONVENTIONAL MYOSIN-IXB; 1.
DR PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00109; C1; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 31..113
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 116..913
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1534..1583
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1605..1790
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 796..818
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 996..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1881..1914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1893..1907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 210..217
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1914 AA; 219622 MW; 69081F64BB3C0FCE CRC64;
MSRHTGGKTA SFLPYLGFMK IHPRVSPSTP AYCPLQIGSQ DTARTVIHNA LVALGLDLSG
RYHLLEVRES GQEERPLELE DRLLERVLLW PPETQRWHPE TQGYYFILQQ TDSGADDYDD
LCGLQAVSQE SILEVLCQRF HRLKIYTYAR NVLVAINPNK FLPLYYNPKY IQMYEKQPLG
RLSPHIFAVA DAAFRAMQVG RVNQCIVMHG DSGSGKTESS SYLVHYLTAL SEKTCSVGLK
RTILGAVPVL QAFGNARTSE NNNSSRFGKF IQLNYLESGV IRGAVIEKYL LEKSRLVSRD
KTERNYHVFY YLLMGATRDE QEEFHLLKPQ DYYYLNQGDL QLDDDANFGQ EYKKLKQAME
MVGFLASTKK HVFSVLSAIL LLGNVTYTLS EDAQVLEVGP AEVLSTLSDL LNVKVDLLVK
TLTRRKVVIT NTLVESPYIL EEASRVRDSM AKSLYGALFD WIIVHVNHAM FNRRDMEESV
SCLSIGILDM FGFENLKKNT FEQLCINYSN EKLQYYINQH IFRFKQEDYI SEGITWQNIA
FADNSGCIQL IDEKPSGLFD LLDQENKLPQ ATDKTLLDKL KQLHQDNPFF ITSSDADLTF
VIQHFAGAVK YHAEDFPREN NEHMRPEVVS LLRSSKQSFF HHLVASSPEA LFRWGVLRAT
IRILAVFKSL GRKRAEESLL FKCFFLPPII HSNSLTLDFS FDRSDELPLD VFEDIFTNYE
NRNCIVKLHK LSLWSFFPRR SRSGRQKQII PKNLMDYVSL QHVVGLTAHD RTSKLIYHPH
RTAKVPTFSA QVQASLNKLL ERIEKAEPFF IFCIRSNDQK KELHFDRELV LQQIKHMGIT
QMVHIHRSGY GAYTFKEFVE KFRLLLPKGA SETPEYITEL FERMGIDKSS YQIGKTKVFL
KEKERQLLLD TLTKEVMRRA IILQRWFRSC LIRLHFLQKR DATMIIQRSW REFYEKKNLA
ATVIQSAWRS SLHMSSLNLG VIKWISCHSL TKKGLQRQRQ VEVSPNRIQQ TDPSGSRAAH
GDSSREAPEG RGSPPPLNRP LSLPLDPKVC IGDQSGRLIR SSKEKQSDDS SPEMQRRAVS
RKEEFSVRFR KQPKRKRRLA YARSGSNRHV EETLSILCMH NLHVQNRRSG WSGNSSFCFA
IQDKRNEGWL LQAFPELESV LKLVAELSEI TQKCIATTKL DLKVNLSILI PSFFSPQKHD
GARLSLPGRT AEEGLGQHSS NPSQLTSPER LNTSFTIFLG WFVAFFFQIK TILLIVRKVF
VCGDTLWTTQ ALRIWFLSRF LKKKAPKYSP VNSPSVHADK SAVPRGKLDT AAAFYDPFEP
GHCLFSSCTV FRHICQLYKL NSRMDPNGTS HCQNVAAETF SRYTPQSYHS PHSDSERVKR
NPTIRISRAT RVMESNASLD REITDPKELQ NLDEFLGSQA YELRTRIKEL SPTESIYLNA
TMQFRETIKE MYSLQHQKPK IGYKDLLKGF HQKVSTLAGS KNKTEVSLVI NLFQSVLDGF
IRGEIKRMES EPTKLTKTTK KRKKKDKCLS SPLDHRFSTY QVSIMQSCDL CGSYIWGMEK
AYMCSACKLI CHKKCLGKII TDCSTRQARQ DDGTPGSLHF GVQVYMLTST ANPVPKVIEM
LLIHVEINGL YTEGLYRKSG SACRAKELHQ ILETDPESAC LDSYVIHTIT GMVKRWLREL
PDPLMTFDLY TDFLHAAELP DKAEKIRAVY QKIDELPPAN YSTLERLIFH LVRVAKEEKH
NKMSPSALAI VFAPCILRSP DVDNPFLSMN DVPKSTACVE ILISEQFRRY KEKMQNIQEL
EYAEAIAVHQ LKLRRQNTRC PLSLFYSADS ETMYRFDMLQ IVEKPPELDV PQEIPSDEIE
KTLIERIRSI KEEKEDLTCR LPNLEHENSD NEILDSASSM SSESLEDRLG SVDS
//
