ID H3DBT3_TETNG Unreviewed; 1641 AA.
AC H3DBT3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=SET domain containing 1A, histone lysine methyltransferase {ECO:0000313|Ensembl:ENSTNIP00000017976.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017976.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017976.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 99883.ENSTNIP00000017976; -.
DR Ensembl; ENSTNIT00000018200.1; ENSTNIP00000017976.1; ENSTNIG00000014930.1.
DR GeneTree; ENSGT00940000162290; -.
DR HOGENOM; CLU_001226_0_0_1; -.
DR InParanoid; H3DBT3; -.
DR OMA; KVSRYPD; -.
DR TreeFam; TF106436; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd12548; RRM_Set1A; 1.
DR CDD; cd19169; SET_SETD1; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR024657; COMPASS_Set1_N-SET.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR044570; Set1-like.
DR InterPro; IPR034467; Set1A_RRM.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR037841; SET_SETD1A/B.
DR PANTHER; PTHR45814; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR PANTHER; PTHR45814:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1A; 1.
DR Pfam; PF11764; N-SET; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01291; N-SET; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 81..169
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1502..1619
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1625..1641
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 192..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..461
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..634
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1097
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1322
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1641 AA; 181197 MW; EF7A9C25672D6C3F CRC64;
MDPDGGAETQ KAVSLQWKSY KLVQDPIIRR VAQKIYRYDG VHFSVPDSGF PPVGELRDPR
PRRLWSRYAE MSLPVPKFKL DEFYVGPIPL KEVTFARLND NIKEPFLADM CAKFGEVEEM
EILFHPKTKK HLGLARVLFT STRGARDTVK QLHNTSVMGN IIHAQLDIKG QQRQKYYDLI
VNGSYTPQTV PLGGKALADS VQPQTPTQPT PDTSSDIRRR LSSELAVLAA GVQTLSTGNA
TPCSGDAGYS DQRLDTPTPP ITGSSVSSQG GGGTPYSSRA GTPFSQDSGY TVSSTVGGYK
VSRYSEDAQE PSVYHRDLAN TATTDIVTTT IRITTTAAAA ARTQPMTGTG SNSSDPRYNS
NSYRSSSNSM SPPPSSYSAY SSSKEPAPAL SQGLDVSSHA GGTNSAERGS LPPASTDKSA
HSALPPPPPP PSEQWTKPKR RPSTPPAPPK TPPPCSPPQI SDSPLPAQRD SSSPEPDSTN
ESLPFAYHSG SLDSRIEMLL KEQKAKFSFL ASDEEDEEDR KEERLRGLRG DGRERRGGSG
EGTAPKEDSP KASSTDTPSL AGAHTPPYNG KSQSSPHSSG EDMEISDDHF GTSMHPAMPS
YPPHLPPPPP PGYSLQPPPP PGIPPLPHME LHPEYPPPIP HQMYDYASSM ELMNQYSGGT
PMSFQMQTHM LSRLHQMRMA SSNSTPGPGE AATADYSSYH LHSMPPPHAH HPYMDQEGSG
GGSHYDQDHR YMPPHMPYPY PEPHNKGDEY RAPGEEMPLL ADNPHEATVQ MALAALIQEM
KNIMQRDLNR KMVENVAFAT FDEWWERKET KAKPFQTMVR GVSALRDDEK KEEKVSRPRE
PLMSLLDWAK SGGMEGFSLR GALRLPSFKV KRKDPLDLEE GDMKRPRPST PPDEDDEAAE
GRIPEADRRG AAMVIKRRKK KPRSRKPWEL GSEGEETSDG SSSEKQEQKQ DKDEEEEGSD
KDSDGSSSQY WEFLSFSTDA LSAESDDESL SSSSEGSSSS ESSSSSSSED EEEGERAESV
DSMDESTMDS MTVGMLADLK FALCHICKTV VLEKLGNKFL FPLSLTDEAK GSKAETMAAP
PKRPSSPPYP RPSSPVVLVP PLKKRRKTVS FSTAEHDSES LPAAPLSPSP QEESPRTSAP
PLMVCRTVQN LPLDHASMCR MAFEEAPLPA PVRAGGRGRE RAELASASTA DLSVLADVAL
KMDPDAGDSE ETETSDEAEE QKISEGVIVL MEHNYCKPPV LTERTSSKDS VLLPADLNTI
SGVLEAPEEV IGEAPKKQKE RQVKKQKKRK LEDSDLEEDV DVEELESGEL TSSDTEDEVV
EEEAGLTTSH RWPKPVPAPE PAPVKYDNRS EFEEMTILYD IWNSGLDGED LTLLRRTYEK
LLQNDHTSDW LNDTHWVNHT VTNLPNPRRK KKNGGGQLRE HVTGCARSEG YYAISRKEKD
VYLDLDLPEQ VIREVENVDT SGANRVLSER RSEQRRLLTV IGTTAVMDSD LLKLNQLKFR
KKKLRFGRSR IHEWGLFAME PIAADEMVIE YVGQNIRQMV ADNREKRYAQ QGIGSSYLFR
VDHDTIIDAT KCGNLARFIN HCCTPNCYAK VITIESQKKI VIYSKQAIAV NEEITYDYKF
PLEENKIPCL CGTENCRGTL N
//
