ID H3DC95_TETNG Unreviewed; 1245 AA.
AC H3DC95;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=L1 cell adhesion molecule, paralog a {ECO:0000313|Ensembl:ENSTNIP00000018138.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000018138.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000018138.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR STRING; 99883.ENSTNIP00000018138; -.
DR Ensembl; ENSTNIT00000018362.1; ENSTNIP00000018138.1; ENSTNIG00000015084.1.
DR GeneTree; ENSGT00940000157506; -.
DR InParanoid; H3DC95; -.
DR OMA; GARTIIQ; -.
DR TreeFam; TF351098; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF39; FI24025P1; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1103..1124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..147
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 158..250
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 266..354
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 359..447
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 453..540
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 542..633
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 696..790
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 795..901
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 905..1001
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1003..1097
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 673..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1200..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1245 AA; 138512 MW; 730AAF8FABD1D34B CRC64;
AMLHTQRQQG GSRGHCSRCL LPLPLRKEGT LLTLAAQPGR AAIQIPSSFC FLAVKIPPAI
TTQPESVTIF SVEDLVMRCE ASGNPPPIFQ WTKDEKRFDP GSDPELKVTE EEGSSAFYTL
SNTMDTLKQY QGKYVCFASN DLGTAVSNTA VLIIDALPSQ QKEKKVNMRA EEGHSIVLNC
NPPQSSMQPI IHWMDARLRH IRLSDRVMVG KDGNLYFANL LTEDSRNDYT CNVQYLTTRT
ILAKEPTTLT VHPCEFLSCS HTSXRPQMMK PIGGHSTYHA LRGQTLELEC IVQGLPTPKV
SWLRRDGEMS ESRTSKEMFD RRLYFNNISE SDGGEYQCIA ENSQGKIVHT YTVTVEASPY
WINAPASQLY APGETVKLDC QADGIPPPTI TWTVNGVPLS ATAVEPRRLL TDSGSLILKD
VSFGDTAIYQ CQASNKHGTI LTNTNVYVIE LPPQILTEDG STYTFVEGQK AVLECETFGS
PKPKVTWESS STSLPLADPR VNLLTNGGLE VSNVSHDDEG IYTCSIQNSN VSVSAELEVL
NRTVILSPPQ ALRMQPGKTA IFTCMYITDP KLHSPVLQWR KNDQKIFESH SDEKYTFEGP
DLIISNVEPG DEGVYTCQII TKLDMAEASS NLTLCGKQLV GQILITEMCQ EXHANLPLWP
YMSYRFRVIA INDQGKSDPS NPSDVYKTPA DAPDSNPTDV RSESIDPDTL VITWEEMDKR
NLNGPDFKYR VMWRRVVGSG PDWHEQYTNA PPLIVNDTQN FSAFEIKVQA VNERGRGPEP
DPVIGYSGED VPLEPPLDVG ILMENSTTIK VTWAPIDKET VRGRLLGYKI YLTRRGSRVH
HQARRTQEPE STVVVQTGAS EEKKLISDLQ PFSSYDIAVS VFNSKSEGPL SETLKFMTPE
GVPGPPMSLV LDSPSETEIT LHWTPPDQPN GILIGYELQY QQIMQSDDSP MQVEDKVNPQ
TTSLMLKGLD RHSHYRFYLM GRTAAGLGEP IKKDGATTLD GLPPANISLS AEEKLVNLSW
EARRRHRNIG FQIHYLNKND GGQWKKTEKV NSSQLFYQLQ GLTPGTQYRL LFTYRNNTFW
ETEIQTKGTR VTEVQPSFAT QGWFIGVVSA VVLLLLVLLI LCFIKRSKGG KYSVKDKEEG
PMDSEARPMK DETFGEYRSL ESDLEEKRTA SQPSLGEDSK LCSEDNLDFN GSSAITTELN
MDESLASQFS RHSEGPEPFH GVPDNSPLNP AAVPPATNGM PNLLN
//
