ID H3DCP0_TETNG Unreviewed; 3451 AA.
AC H3DCP0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Laminin subunit alpha 3 {ECO:0000313|Ensembl:ENSTNIP00000018283.1};
GN Name=LAMA3 {ECO:0000313|Ensembl:ENSTNIP00000018283.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000018283.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000018283.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 99883.ENSTNIP00000018283; -.
DR Ensembl; ENSTNIT00000018508.1; ENSTNIP00000018283.1; ENSTNIG00000015225.1.
DR GeneTree; ENSGT00940000155638; -.
DR HOGENOM; CLU_000301_1_0_1; -.
DR InParanoid; H3DCP0; -.
DR OMA; ISHCAAH; -.
DR TreeFam; TF335359; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 15.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR10574:SF285; LAMININ SUBUNIT ALPHA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 13.
DR Pfam; PF02210; Laminin_G_2; 3.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00180; EGF_Lam; 16.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 10.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..253
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 384..427
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 526..570
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 571..615
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 616..667
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 714..766
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1381..1426
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1471..1519
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1520..1570
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1591..1769
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1803..1849
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1850..1905
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1986..2048
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT DOMAIN 2733..2898
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2899..3062
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3100..3268
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3275..3449
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1002..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1962..1989
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2024..2237
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2272..2299
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2342..2425
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1007..1021
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 403..412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 526..538
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 571..583
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 591..600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 616..628
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 618..635
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 637..646
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 737..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1381..1393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1383..1400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1402..1411
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1495..1504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1520..1532
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1522..1539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1541..1550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1822..1831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1876..1885
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 3451 AA; 381716 MW; F98021F0AEB11E76 CRC64;
GYNLNPPYFN LAEGSRISAT ATCGEDESGR PRYDLYCKLV GGPTIGVPTE NIQGQYCSFC
NSNDPNNAHP VSNAIDGTER WWQSPPLSRG LVHNEVNVTL DLGQLFHVAY ILIKFANSPR
PDLWVLERSV DHGRTFTPWQ YFAHSRRECI EQFGKQPNAR ILHDDDQLCT TEYSRIVPLE
NGEIVVSLVN GRPGAQRFTY SPVLQDFTKA TNIRLNFLRT NTLLGHLISK AQRDPTVTRR
YYYSIKDISV GGRCVCHGHA QVCGGGSNQD RTNRLHCMCQ HNTCGESCDR CCPGFNQKPW
RSATVDSPNE CQPCQCFSHA SDCFYDPEVE KNRASLDTFG RYDGGGVCIN CQHNTAGVNC
ERCIEGFYRP FGVPPESPSG CIPCRCDERT TAGCEMGSGR CICKPQFSGE NCDRCADGYV
YYPQCIRKLC LVAGIYFWCL LLVCLWALAG MVKSERRNLC INLTGISLIS LSVGSMQPVP
SQTLTVIDWI SCIPNIHQIP RRTDCCHAGP SACPPGYFGS PSCRQCVCDY RGTVREVCDA
LGRCLCRQGV NGERCDRCQP GYHHFPNCQG CICDGAGVAN SICSPDGQCV CLTNYRGQNC
DDCAPGYYGY PDCATCQCST EGSYGNICNS VSGQCLCLPG VVGQQCDQCA SGLRFPQCSG
SISRCNSAGT EIFDPQTFQG SCRCLENVEG TLCDRCKPLY WNLAVVNPQG CKECQCDVKG
TLSGVGDCQQ KSGQCHCKPY VSGLSCDTCK DGYFQLQKKK YFGCQDCQCD LGGAVDMSCD
GTSGQCRCRD HVVGRQCREP APNFYFPTLH QLKFEIEDGV TPNSRAVRFG FNQREFPGFS
WRGYAVMSPA QPEVILTLPL GFPGPFHIVI RYSTPRQKGD VRVRARILLV DEAAFQSCCN
WSDQSKEVIF PESPSPTFLT VPGEGFAEPF ELTPGKWIIY LRAEGILLDY LVLLPQDYYE
APMLREKITQ PCTYLPTASR DGFSCLLYKH VPLDGFSSSL GSHGTLSSRN KRRRRRQAHV
RRPTPDHPEM AVLSGRQSNL QLNLRVAHPG PYVLILEYAS EVDAVQNLNM LISEQSGDYV
PARANIYSCT YSFFCRSVAL DGSNRASVLQ LSHKTEVLMQ TSTTLLLLYK VYAIPAEEFS
LDYVDPKVLC VSTHGRFTED SRHCIQSQFD KPASARVLYA SRDGRLSSGT SASLQRQENV
DWRRRRQTVV PVPQSDGVLL KFPQTEITLT PQEPLRGRYV PLVHYHQPEH ASFPVDVRVS
AGREWKGSMN ATFCPAVSGC RKAVFSDGEV ALDFDGNSWQ QPVVSVTVPP NKTLVLDYIL
LVPDSTSTPN LLNEKLIDRS ADFIQKCRGE GFHIDPKTAS QFCRESARAL AAAYNDGALP
CNCDRSGSTG STCDPAGGQC TCRQHVIGRQ CTKCATGYYG FPYCRPCECG RRLCDEVTGK
CICPPQTVKP SCEVCQAQTF SYHPLLGCDG CECSPTGIRD VTRPDCDRLT GQCSCKPRIG
GRQCDRCAPG YYRFPECIPC NCNRDGVTPE VCHPDTGRCL CKKNVAGVEC DACKDGSFYF
DPSNPHGCTS CFCFGATNRC QSSSKRRGKF VDMAGWRLES LDQEVVASVL NPASDTVVAD
VQELSPTVQT LHWVAPSSYL GNKVSSYGGF LTYQSKSFGI PSEGMTLMDR RPDVVLTGQG
MTLIHMAPQV PLPDRLYQGR VQLLEGNWRH GINNKPVSRE ELMMVLADLA GLRIHALYFT
QTQRLGLGEV GLEETSLGGT GGPGNTVEQC SCPPQYTGDS CERCSPGYYR DDSAPFPSRC
VPCECNGHAE ECEDKTGRCL NCRYNTAGDR CERCKEGYYG YATRGTCRVC PCPFSVPTNS
FAVGCREVFG DFQCVCREGY TGNKCQSCAP GYYGDPLVAG GRCQACRCSG NGNSCDSRTG
VCKNTLEPGD TDTDGQCQGE PTKNRTSSVE IARPVPECDN CAQTLLQDLE KLDEELERIK
TQLGNATASA SSQDKLRKLE KNVADIKSLV SKFSSAVNNQ KPRVDQLDED TDNLLKDMNT
LNEKVQDRAA DADRAVTEAD KTHKRAKDLY SEVEKLRKKI QDLLQKLKEA GTTLPSKDLE
KMLRDAKRMV REMENRNFTP QKTAAEKEKD EAKKLLEYIK ANVSRQYDEN NDTAEKLQDL
LKAYEAKLKD LDQALKDAED LVKKANVQNG LNGQTLGNLQ KQATELKKER DMVKGQMDMA
RNELKKTQDL LKMLTDSKTE YEYLAAQLDG AKNEVTKKVN ELSKAASKED IVEAAEKHAQ
DLAKMAKELE DAVKNASGRT EVRNARDAID AYKNITDAIN AAAAAANEAK TAADRALNSV
NSQRLTERAK NLKDNSEDLL TEAERTDKDL TKATSDLRNL NLRLIDADSK KKALQKNLLD
AQNQLRNIRD MINEAKRKSA SANKTASETM DKVSAIKEEI SKIGVSPSDG NLNNVLTDVN
QTINNLLQSI PTLNDKISEV KNLTSQFSQI NNITGNIKKI KELIEQARDA ANRIAIPMKF
SGTGHVELRP PTDLDDLKAY TAMSLSLQRP ESRGDGARRR RQNPESADMF VLYLGSRNSS
KNYIGMVVRN NVLYGVYKLN GQEYKIQTET IIRSPSEPAK FDRVDLNRIY QDAEITFTKD
TSGTSPVSSK TNNIGDDSKN LLDLSPGDVV FYVGGYPANF TPPDSLNLPM YDGCIEFFSF
NDKAISLYNF RARDKINLQT PCKSSRYVPP VTSNYYEGTG YSRVPIDKQS SILLIAMSLY
TRSENGLIAY FSHEFFLFPT QNNYFAVTME KGVVFIHSNL LESPVTSNLK LFPVGIIGDK
VNGKMTVRVA SKEAAVANVK YNFDEFTELY VGGIPEAMRE RYPFVFLSVF PFKGCLQNLK
INKGFQPPTE QVGVSKGCPV SSLVIRKAKF DLGSALSSDL QGFSLDNKVT VSLGFKSTQS
RGLFLQDKQL ANGMNLELQN GHVVLKFNDK MWRSNKQYDD DQWHYLTVTR SAGRTELLID
DEDRGQEESG TSINDTGSLL ILGGNEFRGC VSNLYTRRPN SLYKAEDFST FQSSGDVLLD
VCAADSPAQL MRDRSAKKDV PMQDINEMSP CASPATVKHA YRMYGSVSSL SFSLPLQVLQ
PRPQISLDVR TRAAEGLLFF AATRGGRAHL ALYMSKGRIR LSVGKEKEIF NREKYNDGKW
HTVMFSLEKR LFRLVVDGIR AQDGQMVNAE LAAMQHFLSP VYLGGAPEAF HKESKGLPKQ
SVPGCIRNFK MNGALMTNPT TNRGAGPCLA GPTQKGAYFA GNRAHVIVND SFVLNSTFEL
LFSIRPQSPT GLLLHVGVFS ESHYLSVYML RGEVVAQANS GKGELKVTVK PKTSLCDGMF
HKISVIKRKN VIQLHVDTVD SYKIGPPLPA TTLTKSSLYV GGIPETLVQQ PLPVRASFVG
CIQDMSVNSE PVSFERPPAV FGPVNLKECP G
//
