ID H3DCP6_TETNG Unreviewed; 1770 AA.
AC H3DCP6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Rho GTPase activating protein 21b {ECO:0000313|Ensembl:ENSTNIP00000018289.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000018289.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000018289.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR STRING; 99883.ENSTNIP00000018289; -.
DR Ensembl; ENSTNIT00000018514.1; ENSTNIP00000018289.1; ENSTNIG00000015231.1.
DR GeneTree; ENSGT00940000155406; -.
DR HOGENOM; CLU_001776_0_0_1; -.
DR InParanoid; H3DCP6; -.
DR OMA; FCENDCP; -.
DR TreeFam; TF329345; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 11..110
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 779..893
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1005..1198
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 359..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1614..1642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1383
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1770 AA; 197452 MW; 171035315760BF8A CRC64;
EEEFSWPRPK TVLLRRTPQG FGFTLRHFIV YPPESSMHLF LEDEHGRRGW RQRNKLEPMD
TIFVKQVKEG GPAHGAGLCT GDRLVKVNGA SIIGKAYCEV ISLIQESSGE FLELCVMPKD
EDILQLLSYL LFLALVAYSQ DAYLRGHSNY SGNVHHIPDP PPLCYPRVEC KPTGMNQATD
LTEQVNRGLT APTDHGYRKE ITVPPSPPHP QNFPKSQMAV CIRGDGVRTV VVPPEKTHMG
RMGPAHRIDY IDPVFARGRP ASLAQYPHHR KNDFYPGGPG KHSYGGQPTH YPANQQNIDW
RNYQTYRDYI DNKGIHSHSA RTIQERLDSL RATGHNVFGV THHIHQGDWG AKGLRRRSTS
HDRSYRGPSP HFQIAPRSAS QDRLLSAERI SQTRNWPPRS VSQDGLMHKA RAHSIDYVEH
GELPWPSEKR AEYARADQGA RPSRQSVPRH AMLYRPPVAH TGGMRGPPNS SLYSKGPDSL
QTRSSPMLSE RPLHFSKSPS TEHSYIDQRV AVKSTHGTPN AQQGGSRMRA ESMKPAEACR
ETPVMGHRSS SCSAPKQMQQ KPSILKPHHQ DSPSQVNGRS LSESGVVLRE KPPPGKNPSP
LRHPSYILAI TDDGADSTAD VSTCWLPNDA RREMHMRRLE ERHVSCSSNL DQSLDSIPFI
DEPISPSVDQ EAALIPPSAV ISVAQSVTPD TSSPGSPCHL THRQLSHDQE SLRNSLLESE
SVSKTERSKS YAEGLENYQE EGRGRSSSKH LPSLKVLKKA LDGHKFVGDR RNSLYIFDDS
SKEGFLNFRQ LTTEKNKRVG GGMRSWKQMY AVLQGHTLSL YKDRKDALSH TSAQSDEDPL
RISVKACLID ISYSETRRKN VLRLTTSDCE YLFQADGRED MLTWIRVIQN NSNPDEENAS
VTSQDLISRK IKEYNMMSAP SSRSEPSPKA ARQSLSIKQA FLGGKSDGRI HSPHSPKTGE
ERRALKDLPD EASPPRDRAA WKLGIAGIMR RPFEKKTPAG VMFGVRLDDC PPAQTNRFVP
LIVEVCCKVL EERGLEYTGI YRVPGNNAAI SSMQEELNSK GMADIDIQEE KWRDLNVISS
LLKSFFRKLP EPLFTNEKYA DFIEANRIED SVERLKELRR LIHELPDHHY ETLKFLCAHL
KRVSGHCEKN KMEPRNLAIV FGPTLVRTSE DNMANMVNHM PDQCKIVENL IQQYDWFFLD
ECDEDPITTA EQESTVQSQP VPNIDHLLSN IGRTAPSPGE VSDSACNDSS KAKQGLWASG
KDQCSKEMLR SSFFASRKRK KPKDKAHPSS SDDDLDDAFH RKELQEKNQQ QVLWSPHSQE
GTDETVERDR NSSEEQLNPP SRKESLSSSL ISQSSPPLPS EHISPPLRSG PQYTSPPPSP
DLSYRLPVAH QSCLSDPPSN FDDTVSDLGT MNSTSSHASV PRVRRRKVPA QGPEVGPSGP
GAEVCSITSD YSTTSSMTFL TGAELSTLSP EVQSVAESRG GDDADDERSE LISEGRAMET
DSESDLSVFT VTRSDRREPQ DAPRPIPSHR LIECDTLSRK KAAQQKTNSQ TSLEGAPGDK
DGSRLSRVLG SVKGRSTGSL ASSSRGELDK AEPTWKLKIT DRLKVRLRMS ADDMFGVGSQ
RSRSPEGRSK KKNIRRRHTM GGQRDFAELS VLGDWPGDIG AGSRSELSAV DRLKPKCSSQ
DFSIGEWIAR ERHRTSNPEV SQDLCDPQAD LRRTHSQNLG ASSSCEVLRS SAEVSNGDVP
QSKNLSLSAT AHPHKLTSSQ VVHSRFYQYL
//