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Database: UniProt
Entry: H3DCP6_TETNG
LinkDB: H3DCP6_TETNG
Original site: H3DCP6_TETNG 
ID   H3DCP6_TETNG            Unreviewed;      1770 AA.
AC   H3DCP6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=Rho GTPase activating protein 21b {ECO:0000313|Ensembl:ENSTNIP00000018289.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000018289.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000018289.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC       Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC       vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004395}.
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DR   STRING; 99883.ENSTNIP00000018289; -.
DR   Ensembl; ENSTNIT00000018514.1; ENSTNIP00000018289.1; ENSTNIG00000015231.1.
DR   GeneTree; ENSGT00940000155406; -.
DR   HOGENOM; CLU_001776_0_0_1; -.
DR   InParanoid; H3DCP6; -.
DR   OMA; FCENDCP; -.
DR   TreeFam; TF329345; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd01253; PH_ARHGAP21-like; 1.
DR   CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR   Gene3D; 1.20.5.220; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041681; PH_9.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF15410; PH_9; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT   DOMAIN          11..110
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          779..893
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1005..1198
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          359..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          706..750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          944..976
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1209..1447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1464..1592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1614..1642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..527
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..582
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..748
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        950..976
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1209..1225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1235..1256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1285..1307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1321..1337
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1338..1358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1359..1383
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1393..1419
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1478..1501
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1510..1524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1541..1556
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1570..1584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1770 AA;  197452 MW;  171035315760BF8A CRC64;
     EEEFSWPRPK TVLLRRTPQG FGFTLRHFIV YPPESSMHLF LEDEHGRRGW RQRNKLEPMD
     TIFVKQVKEG GPAHGAGLCT GDRLVKVNGA SIIGKAYCEV ISLIQESSGE FLELCVMPKD
     EDILQLLSYL LFLALVAYSQ DAYLRGHSNY SGNVHHIPDP PPLCYPRVEC KPTGMNQATD
     LTEQVNRGLT APTDHGYRKE ITVPPSPPHP QNFPKSQMAV CIRGDGVRTV VVPPEKTHMG
     RMGPAHRIDY IDPVFARGRP ASLAQYPHHR KNDFYPGGPG KHSYGGQPTH YPANQQNIDW
     RNYQTYRDYI DNKGIHSHSA RTIQERLDSL RATGHNVFGV THHIHQGDWG AKGLRRRSTS
     HDRSYRGPSP HFQIAPRSAS QDRLLSAERI SQTRNWPPRS VSQDGLMHKA RAHSIDYVEH
     GELPWPSEKR AEYARADQGA RPSRQSVPRH AMLYRPPVAH TGGMRGPPNS SLYSKGPDSL
     QTRSSPMLSE RPLHFSKSPS TEHSYIDQRV AVKSTHGTPN AQQGGSRMRA ESMKPAEACR
     ETPVMGHRSS SCSAPKQMQQ KPSILKPHHQ DSPSQVNGRS LSESGVVLRE KPPPGKNPSP
     LRHPSYILAI TDDGADSTAD VSTCWLPNDA RREMHMRRLE ERHVSCSSNL DQSLDSIPFI
     DEPISPSVDQ EAALIPPSAV ISVAQSVTPD TSSPGSPCHL THRQLSHDQE SLRNSLLESE
     SVSKTERSKS YAEGLENYQE EGRGRSSSKH LPSLKVLKKA LDGHKFVGDR RNSLYIFDDS
     SKEGFLNFRQ LTTEKNKRVG GGMRSWKQMY AVLQGHTLSL YKDRKDALSH TSAQSDEDPL
     RISVKACLID ISYSETRRKN VLRLTTSDCE YLFQADGRED MLTWIRVIQN NSNPDEENAS
     VTSQDLISRK IKEYNMMSAP SSRSEPSPKA ARQSLSIKQA FLGGKSDGRI HSPHSPKTGE
     ERRALKDLPD EASPPRDRAA WKLGIAGIMR RPFEKKTPAG VMFGVRLDDC PPAQTNRFVP
     LIVEVCCKVL EERGLEYTGI YRVPGNNAAI SSMQEELNSK GMADIDIQEE KWRDLNVISS
     LLKSFFRKLP EPLFTNEKYA DFIEANRIED SVERLKELRR LIHELPDHHY ETLKFLCAHL
     KRVSGHCEKN KMEPRNLAIV FGPTLVRTSE DNMANMVNHM PDQCKIVENL IQQYDWFFLD
     ECDEDPITTA EQESTVQSQP VPNIDHLLSN IGRTAPSPGE VSDSACNDSS KAKQGLWASG
     KDQCSKEMLR SSFFASRKRK KPKDKAHPSS SDDDLDDAFH RKELQEKNQQ QVLWSPHSQE
     GTDETVERDR NSSEEQLNPP SRKESLSSSL ISQSSPPLPS EHISPPLRSG PQYTSPPPSP
     DLSYRLPVAH QSCLSDPPSN FDDTVSDLGT MNSTSSHASV PRVRRRKVPA QGPEVGPSGP
     GAEVCSITSD YSTTSSMTFL TGAELSTLSP EVQSVAESRG GDDADDERSE LISEGRAMET
     DSESDLSVFT VTRSDRREPQ DAPRPIPSHR LIECDTLSRK KAAQQKTNSQ TSLEGAPGDK
     DGSRLSRVLG SVKGRSTGSL ASSSRGELDK AEPTWKLKIT DRLKVRLRMS ADDMFGVGSQ
     RSRSPEGRSK KKNIRRRHTM GGQRDFAELS VLGDWPGDIG AGSRSELSAV DRLKPKCSSQ
     DFSIGEWIAR ERHRTSNPEV SQDLCDPQAD LRRTHSQNLG ASSSCEVLRS SAEVSNGDVP
     QSKNLSLSAT AHPHKLTSSQ VVHSRFYQYL
//
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