ID H3DF85_TETNG Unreviewed; 1423 AA.
AC H3DF85;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 08-NOV-2023, entry version 74.
DE SubName: Full=Rap guanine nucleotide exchange factor (GEF) 6 {ECO:0000313|Ensembl:ENSTNIP00000019179.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019179.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019179.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR STRING; 99883.ENSTNIP00000019179; -.
DR Ensembl; ENSTNIT00000019407.1; ENSTNIP00000019179.1; ENSTNIG00000016088.1.
DR GeneTree; ENSGT00940000158124; -.
DR HOGENOM; CLU_002782_0_1_1; -.
DR InParanoid; H3DF85; -.
DR OMA; GTCEYEF; -.
DR TreeFam; TF313184; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF222; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 124..224
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 256..369
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 374..444
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 591..677
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 702..929
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 27..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..85
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1423 AA; 157576 MW; D96A383509B06171 CRC64;
LGQSESVQLP GDLNKMHLTD HAHQQVMHVP PSQSGCSIAS DSGSSSLSDI YQATESELGD
VDLSGLPEAA VDSEEDEEED EDLERASDTL LGRDLVRECL EKDPVDRNDD DIEQLLEFMH
QLPAFANMTM SVRRELCSVM VFEVVEQAGT IILHNKQELD LWYVILNGAV EISYPDSRME
TLCMGNSFGI SPSLDKQYMH GEVRTKGDDC QFVCIAQEDY WRILNHVEKN THKVEEEGEI
VMVKEHRELD RSGTRKGHIV IKGTPERLIM HLVEEPSVVD PTYIEDFLLT YRTFLSNPME
VGKKLLEWFQ VDTLRDTVTR IVLLWVNNHF NDFEGNPAMT RFLEEFEKLL ETTKMKGHLR
LLNIACAAKA KLRQITLQKA SRESPLYFSV QGGSERGFGI FVDSVEEGSK AAETGLKRGD
QIMEVNGQNF ENIPITKAVD ILRNNTHLSL TIKTNIFVFK ELLSRVLHEK KNGGPHIPKI
QEKKGNRFSI PDLPGDMECP LTQEPRKCSN TVSGVSFLSP FNSNPPLTPI PALLCSDGGM
VQSQDDSIVG TKQCRHSVAI MPIPGNLSSS SPDLLQPATS VLDFSNPADI PDQVIRVFKA
DQQSCYIIIS KDTTAKDVVA HSVNEFGLIA APETYSLCEV SVSPEGFIKQ RRLPDQLSKL
ADRIQLNGRY YLKNNMETET LCSDEDAQDL LRESQISLLQ LSTMEVAAQL SMRDFELFRN
IESTEYLDDL FKLDTSIGSR NLKQFEEVIN QETFWVASEI LKEPNTLKRM KTIKHFIKIA
LHCRECKNFN SMFAIISGLN LAPVARLRSS WEKLPSKYEK LFGDLQDVFD PSRNMAKYRN
VLSSQSMQPP IIPLFPVVKK DLTFLHEGND STVDGLVNFE KLRMIAKEIR HIVRLTSANM
DPALMFRQRK SLPPSCMSLS QGSTNSNMLD VQGGAHKKRV RRSSLLNAKK LYEDAQMARK
VKQYLSNLTV ETDEEKFQFM SLQCEPSYST LSKYLSERRS TKSDMSPVSL RSALPSAKTQ
NRVSQVLQVQ VPLNPLRKKS NAKDTGPPNS NSPQVVKKPP VSSSEEWNTK RPSDDTVSTV
SSLHSSPTVS PQGSPRKGYT FLPAGKADNL SDSSHSEISS RSSICSVDSM PAPGPDERCS
GTNRTAAGVA TTTPAMVTDS TAHTHFNADY SQPSTSNSSP SARGYVPRGS AVTSSASTEE
LTPDHTSLDS VADSGRGSWT SCSSNSHDSF QSLPSSSCRP WDHGIHGHPL AFAHLGGFKH
TQLAGPIAEM EAATQAWLKE DGAAKQHSRN SSSDLSNQSR QSWASSSSLS DTYEGNYGTI
KRRNASEHPS SPTNEEGGQS TDHVYKTVTS STEKGLIVYC VTSPSKDERY RAPPPTPPGY
QGLALGDLGL ADGSASGPGG LGPRPPHLRP PDYSVALQRS KLL
//