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Database: UniProt
Entry: H3DF85_TETNG
LinkDB: H3DF85_TETNG
Original site: H3DF85_TETNG 
ID   H3DF85_TETNG            Unreviewed;      1423 AA.
AC   H3DF85;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   08-NOV-2023, entry version 74.
DE   SubName: Full=Rap guanine nucleotide exchange factor (GEF) 6 {ECO:0000313|Ensembl:ENSTNIP00000019179.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019179.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000019179.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC       {ECO:0000256|ARBA:ARBA00010829}.
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DR   STRING; 99883.ENSTNIP00000019179; -.
DR   Ensembl; ENSTNIT00000019407.1; ENSTNIP00000019179.1; ENSTNIG00000016088.1.
DR   GeneTree; ENSGT00940000158124; -.
DR   HOGENOM; CLU_002782_0_1_1; -.
DR   InParanoid; H3DF85; -.
DR   OMA; GTCEYEF; -.
DR   TreeFam; TF313184; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd01785; RA_PDZ-GEF1; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF222; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT   DOMAIN          124..224
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          256..369
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          374..444
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          591..677
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          702..929
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          27..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          916..936
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          998..1144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1166..1226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1281..1342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1366..1423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..85
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..931
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        998..1035
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1043..1095
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1107..1127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1288..1342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1423 AA;  157576 MW;  D96A383509B06171 CRC64;
     LGQSESVQLP GDLNKMHLTD HAHQQVMHVP PSQSGCSIAS DSGSSSLSDI YQATESELGD
     VDLSGLPEAA VDSEEDEEED EDLERASDTL LGRDLVRECL EKDPVDRNDD DIEQLLEFMH
     QLPAFANMTM SVRRELCSVM VFEVVEQAGT IILHNKQELD LWYVILNGAV EISYPDSRME
     TLCMGNSFGI SPSLDKQYMH GEVRTKGDDC QFVCIAQEDY WRILNHVEKN THKVEEEGEI
     VMVKEHRELD RSGTRKGHIV IKGTPERLIM HLVEEPSVVD PTYIEDFLLT YRTFLSNPME
     VGKKLLEWFQ VDTLRDTVTR IVLLWVNNHF NDFEGNPAMT RFLEEFEKLL ETTKMKGHLR
     LLNIACAAKA KLRQITLQKA SRESPLYFSV QGGSERGFGI FVDSVEEGSK AAETGLKRGD
     QIMEVNGQNF ENIPITKAVD ILRNNTHLSL TIKTNIFVFK ELLSRVLHEK KNGGPHIPKI
     QEKKGNRFSI PDLPGDMECP LTQEPRKCSN TVSGVSFLSP FNSNPPLTPI PALLCSDGGM
     VQSQDDSIVG TKQCRHSVAI MPIPGNLSSS SPDLLQPATS VLDFSNPADI PDQVIRVFKA
     DQQSCYIIIS KDTTAKDVVA HSVNEFGLIA APETYSLCEV SVSPEGFIKQ RRLPDQLSKL
     ADRIQLNGRY YLKNNMETET LCSDEDAQDL LRESQISLLQ LSTMEVAAQL SMRDFELFRN
     IESTEYLDDL FKLDTSIGSR NLKQFEEVIN QETFWVASEI LKEPNTLKRM KTIKHFIKIA
     LHCRECKNFN SMFAIISGLN LAPVARLRSS WEKLPSKYEK LFGDLQDVFD PSRNMAKYRN
     VLSSQSMQPP IIPLFPVVKK DLTFLHEGND STVDGLVNFE KLRMIAKEIR HIVRLTSANM
     DPALMFRQRK SLPPSCMSLS QGSTNSNMLD VQGGAHKKRV RRSSLLNAKK LYEDAQMARK
     VKQYLSNLTV ETDEEKFQFM SLQCEPSYST LSKYLSERRS TKSDMSPVSL RSALPSAKTQ
     NRVSQVLQVQ VPLNPLRKKS NAKDTGPPNS NSPQVVKKPP VSSSEEWNTK RPSDDTVSTV
     SSLHSSPTVS PQGSPRKGYT FLPAGKADNL SDSSHSEISS RSSICSVDSM PAPGPDERCS
     GTNRTAAGVA TTTPAMVTDS TAHTHFNADY SQPSTSNSSP SARGYVPRGS AVTSSASTEE
     LTPDHTSLDS VADSGRGSWT SCSSNSHDSF QSLPSSSCRP WDHGIHGHPL AFAHLGGFKH
     TQLAGPIAEM EAATQAWLKE DGAAKQHSRN SSSDLSNQSR QSWASSSSLS DTYEGNYGTI
     KRRNASEHPS SPTNEEGGQS TDHVYKTVTS STEKGLIVYC VTSPSKDERY RAPPPTPPGY
     QGLALGDLGL ADGSASGPGG LGPRPPHLRP PDYSVALQRS KLL
//
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