ID H3DFR3_TETNG Unreviewed; 1030 AA.
AC H3DFR3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=StAR-related lipid transfer (START) domain containing 13b {ECO:0000313|Ensembl:ENSTNIP00000019357.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019357.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019357.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3DFR3; -.
DR STRING; 99883.ENSTNIP00000019357; -.
DR Ensembl; ENSTNIT00000019586.1; ENSTNIP00000019357.1; ENSTNIG00000016263.1.
DR GeneTree; ENSGT00950000183061; -.
DR HOGENOM; CLU_004367_0_0_1; -.
DR InParanoid; H3DFR3; -.
DR OMA; CASTLEI; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04375; RhoGAP_DLC1; 1.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR12659:SF6; STAR-RELATED LIPID TRANSFER PROTEIN 13; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 579..785
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 831..999
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 95..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 115900 MW; E002365262CF0AC3 CRC64;
YAFIHPDSQF PIDITPVKKD HDFLEKDLVE PLCRRLNTLN KCASMKLDVN LPKKKSEDSD
EEDLFAISDK WTFEWSSRRW SRLQDIDCLL ENHEERQPSR DGVPLKNTTS SESVLTDLSE
PDVSSLHSES SGGSGQKGLS TEDPESAAMP DSTSLTMPHT PNTHYGLLSN RHNKTSRSRT
KDFMKHIETL RSRGTTGRGG KALVISSPVL QEQAPSLKTL QCVDIINGDG GAPESFKITP
SQSGSEGSSN SSGSTVSTPS LKERKPHYAD YKRSGMYLED VDIFSGTQAH KVTEQNRRNE
FCSYEDLVVH IPKDHKPGTF PKALSIESLS PTNGASITWH TGSMHLDSPM IACPKESRPI
TQCCTRGSRI SVYDNVPGSH LYASTGDLID LEKEDLFPHL DDILLHVNGL QQIVDHWSKN
VLHVSEGLGQ GQVGVERNER VGNQSSSQIT LDLVTEGHAP PIYEEKDQVS LAETESTRLR
ERRDSGVGAS LTRPNRFCAR LRWPSFQISH RLSHSVASLQ ITNQTAGQLS LLQKFSLLRL
TAIMEKYSLS NKHGWSWSVP KFMKRMKVPD YKDKNVFGVP LIVHVQRSGH PLPLGLQQAL
RYLRSQCLDQ VGLFRKSGVK SRIQALRQMN ESSPDNVNYE DQSAYDVADM VKQFFRDLPE
PLLTSKLGET FLHIYQYVPK DQRLQAVQAA IMLMSDENRE ALQTLLCFLS DVTSSVEENQ
MTPMNIAVCL APSLFHLNIL KKDNLSPKAM RKKYATGRPD QKDLNENLAA TQGLAHMITE
CNRLFEIPHE MITQSRNSYV EADLHAPTIG ELCKQLEDDD GTYQTHMEGR LHNLLKEARE
KSKYWISCSS SDNTELYCKK VGDGNPLRRW RVSVEVEAPP SVVLNRVLRE RHLWDVDLLQ
WKVYETLDKQ TEVFQYALSC MPPHPSREFL VLRSWRTDLP KGACSLVSVS IEMEDCPPLG
GVRAVVLESN YLLEPCGSGK SRLTHISRVD MKGRTPDWYN KAFGHLCAAE AARIRNSFQP
LITDGPETKI
//
