ID H3DGJ0_TETNG Unreviewed; 315 AA.
AC H3DGJ0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Ras association domain family member 4a {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019634.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3DGJ0; -.
DR Ensembl; ENSTNIT00000019864.1; ENSTNIP00000019634.1; ENSTNIG00000016534.1.
DR GeneTree; ENSGT00940000160176; -.
DR HOGENOM; CLU_018893_1_0_1; -.
DR OMA; RMCERQT; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17222; RA_RASSF4; 1.
DR CDD; cd21894; SARAH_RASSF4; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR033622; RASSF4_RA.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF4; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 166..254
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 262..309
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
FT COILED 281..308
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 315 AA; 36354 MW; AFFF937F48EA460D CRC64;
FISRSDILSL LRTYNCYHEG KNFQLRTREE DGEFILEGLL NIHWGLRRPI RLQMYDGNER
FRPNRWGSCS GSVWRSGAKK GNVSSTFCPL SCRNLALSRN FAPTEGENVP AAGDDAGVPE
EDDCPQLLRT RSDASFVHIQ RRTKIRSARD LQRLRTHRFS INGHFYNHKT SVFTPAYGSV
TNVRVNSSMT TGQVLNLLLH KFRVENKSDE FVLYMVHESG ERTRLRDDEH PLVTRVLHGP
CEKISKILIT EADLGEEVTY DVAQYIKLEI PVLDSFVQKL KEEEEREIKK LTRKYSALKA
MIQHQLEDRA CPSDR
//
