ID H3DGQ9_TETNG Unreviewed; 960 AA.
AC H3DGQ9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=General transcription factor IIA, 1-like {ECO:0000313|Ensembl:ENSTNIP00000019703.1};
GN Name=STON1 {ECO:0000313|Ensembl:ENSTNIP00000019703.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019703.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019703.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Stoned B family.
CC {ECO:0000256|ARBA:ARBA00005579}.
CC -!- SIMILARITY: Belongs to the TFIIA subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00010059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H3DGQ9; -.
DR STRING; 99883.ENSTNIP00000019703; -.
DR Ensembl; ENSTNIT00000019933.1; ENSTNIP00000019703.1; ENSTNIG00000016599.1.
DR GeneTree; ENSGT00940000158817; -.
DR HOGENOM; CLU_008237_0_0_1; -.
DR InParanoid; H3DGQ9; -.
DR OMA; CSANPGN; -.
DR TreeFam; TF318623; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd07976; TFIIA_alpha_beta_like; 2.
DR Gene3D; 1.10.287.100; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR012320; SHD_dom.
DR InterPro; IPR004855; TFIIA_asu/bsu.
DR InterPro; IPR009088; TFIIA_b-brl.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF339; STONIN-1; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF03153; TFIIA; 1.
DR SMART; SM01371; TFIIA; 1.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF47396; Transcription factor IIA (TFIIA), alpha-helical domain; 1.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR PROSITE; PS51072; MHD; 1.
DR PROSITE; PS51070; SHD; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 57..190
FT /note="SHD"
FT /evidence="ECO:0000259|PROSITE:PS51070"
FT DOMAIN 194..502
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 638..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 106803 MW; 74632B9BA3B197C4 CRC64;
SFSLICHKLE GLRADTDRGT ETEKEAERQL SGRSEIFREG SSHCVPRGLF RSQKRDGWPV
LIRIPEKKNR MSSRQWGPIY LRLLPGGVLQ MYYEKGLEKP YKEFQLLPQC RVSDLKVESY
GEPRKVLTLK VELFSYAERK RYHPKLEVAH EAEVEQLLKF GSTEHADMED LAVSMEEEIF
KLSLSYQPRR HFEAEELSLQ ITDHMWVQLD KCGAVMARTA LTQIHCLAFL NAPGDCFLAL
NDLGLLRLDP SYGSQEAGEL WMEIADCSFH KCVNESEFHR SRLVKFSPPE ACRAELMRYK
TALLGCTQMP FVVKATVTVQ GAYVELQAFL NMTPTFLSFM GVSDTHPLCE NVVVRVPVPA
NWVRATQAGA LLRQRSLKAR MNRNACLGAV RTTDSRPVMQ VSVGTVKYEN VYSAIVWRID
RLPAKNTAVD HPHSFSCKLE LGSDQEIPSD WYPFVSMECE IMGAVVSQTR VKSLGTTSDM
QPQKHVTSWT RYHCQAKFYF SIIDDVIESI RELFLDEGLE DRLVDDLRHL WESKMMQSKA
MEDLRKGNAN PSNFVLQLPA NYRQADQEVA ASVMIPSSQN IHSFPRLKYN SETLATFSLP
AGLAYPVQIP AGVTLQTASG QLYKVNVPVV VTQTAAAAGA PPCPSQHQTG EPSSVRAPSV
TQAPNPGQSH TSLASSQESS LPGLPPVPPA EAPQRRQERS PGQPVASGES EPSSQPATNH
LPCSQVVDLQ SGAEEPCAQT EPFKSSNIDD ILNNSAGSRS NSEWNSITYS THSKPSVSFP
IHTGCRRFSR SAPQNLKRSL SDVQHRLPPS VQIPNQIGAL AHYSELSDIV QLDGPADNSD
SEGEEERAAL EENDFLGMIN AEAIKALQEG EASSDGTSGS TSGDSADELT NVEEEDPLNS
GDDVIEQDIP DLFDTDNVIV CQYDKIHRSK NRWKFHLKDG VMCYGGRDYV FSKAVGEAEW
//
