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Database: UniProt
Entry: H3DGX3_TETNG
LinkDB: H3DGX3_TETNG
Original site: H3DGX3_TETNG 
ID   H3DGX3_TETNG            Unreviewed;      1220 AA.
AC   H3DGX3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=Nidogen 1a {ECO:0000313|Ensembl:ENSTNIP00000019767.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019767.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000019767.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC       Secreted, extracellular space, extracellular matrix, basement membrane
CC       {ECO:0000256|ARBA:ARBA00004302}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; H3DGX3; -.
DR   STRING; 99883.ENSTNIP00000019767; -.
DR   Ensembl; ENSTNIT00000019997.1; ENSTNIP00000019767.1; ENSTNIG00000016660.1.
DR   GeneTree; ENSGT00940000156318; -.
DR   HOGENOM; CLU_003163_1_0_1; -.
DR   InParanoid; H3DGX3; -.
DR   OMA; DYRPDYR; -.
DR   TreeFam; TF320666; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 3.
DR   CDD; cd00255; nidG2; 1.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR   Gene3D; 2.10.25.10; Laminin; 5.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR   InterPro; IPR009017; GFP.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR003886; NIDO_dom.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR46513:SF6; NIDOGEN-1; 1.
DR   PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF12947; EGF_3; 2.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07474; G2F; 1.
DR   Pfam; PF00058; Ldl_recept_b; 3.
DR   Pfam; PF06119; NIDO; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00682; G2F; 1.
DR   SMART; SM00135; LY; 5.
DR   SMART; SM00539; NIDO; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF54511; GFP-like; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR   SUPFAM; SSF63825; YWTD domain; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS01186; EGF_2; 4.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51120; LDLRB; 3.
DR   PROSITE; PS51220; NIDO; 1.
DR   PROSITE; PS50993; NIDOGEN_G2; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   4: Predicted;
KW   Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00500};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..1220
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003583429"
FT   DOMAIN          107..270
FT                   /note="NIDO"
FT                   /evidence="ECO:0000259|PROSITE:PS51220"
FT   DOMAIN          412..644
FT                   /note="Nidogen G2 beta-barrel"
FT                   /evidence="ECO:0000259|PROSITE:PS50993"
FT   DOMAIN          643..684
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          685..727
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          734..777
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          778..814
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          821..894
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   REPEAT          963..1005
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1006..1048
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   REPEAT          1049..1093
FT                   /note="LDL-receptor class B"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT   DISULFID        864..871
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ   SEQUENCE   1220 AA;  133107 MW;  F68270B2492FA784 CRC64;
     QLLLKTRIMG RQERGWLVCL SFLGFVASVE SITRGELFPF GPSAGDQILA AGSDQTHRLE
     LDSPVLFYDG TFDSIFVNTN GFVATAEPTG ESTYLGKMPS RFGMIAALQG DLDTSDEVGR
     VYFRQDSSPE VLGRAAEHMN RAFPEDPAVS PTRAVIVTWA DVAPREPESR GDTLVRKRNT
     FQLVIASTKN ASFAIVLYAN DGIQFTSTTV EGGVAILHAG FSKGIVQGFL FSSQGPYFRI
     TTDEEESIRA LAEETNSGMQ GVWVYEIGTS PYFTNVAPGE VPYLPTEAPT PEIFEVDGGS
     LGFDRGQQVE YPTFEPEGDQ IQVHPVQYQP GQPGNPEVLV VEDADIDVDA FPSVSSLRSC
     TCPVFSYNLG TCASGRNTCS QYADCKDYSS GFCCHCRPGF YGNGIQCTAE GKPQRTNGKI
     HGSVYVGNSP SPVQLTGNDL HSYVVVNEGR SYVAISEIPD SLGPSLQPLA AIGSAIGWAF
     ALEQPGFKNG FSIIGGEFTR QVEVTFQPGN EKLTIRQEFK GIDEHDHLVM STTMDGRIPQ
     VPYGATVKIE PYSEIYHYSS DLITSSSTRD YVVNLPDGSA DALTYQWRQT ITFRSCQHGD
     AWRDVKPTQL LSVDGVLAMY DSNEVMRFTM TNKIGDVNGG EPEENPCFTG RHGCDTNAIC
     RPEQGTQFTC QCAAGFNGDG HICYDVDECR EEPQICGFHA VCNNHPGTFR CECEDGYQFG
     SDGRTCTASA LSRPVDACDE GTHTCDIQER ARCTYTGGSS YSCSCLPGFS GDGRTCQDID
     ECQAGPCHRD AECYNNEGSF TCQCAPGYYG DGFLCTPERT KTRCQSHRES LLSVTEYGPR
     GPRPSGGHYI PRCDENGAYE PTQCHGSSGY CWCVDRNGQE IPGTRSEPGS SPMCEGGLRP
     PVGPTPRPDV HPLPPGTHLL FTQSGRIEHV PLEGSAMKKD DAKPVLHLPE KVVIGVAYDC
     VEKMVYWTEI TSPSISKASM EGGDPVSVVR SDLGSPEGIA IDHLGRTVFW TDSVRDRIEV
     ASLDGSQRRV IVDSDLVNPR AIVADPPSGN LFWTDWNRDA PKIETSYMDG SNRRVLVKDD
     LGLPNGLTYD RHSFLLCWAD AGTHAMECMD PARGDRRKVA EGVRYPFAIT SLGNTVYYTD
     WQREAVVAVD RHTGEETDQF QPQKRTKLYG LTTTYAQCPS GQNYCSVNNG GCTHLCLATP
     LGRSCRCPND AASVGCVERD
//
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