ID H3DGX3_TETNG Unreviewed; 1220 AA.
AC H3DGX3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Nidogen 1a {ECO:0000313|Ensembl:ENSTNIP00000019767.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019767.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H3DGX3; -.
DR STRING; 99883.ENSTNIP00000019767; -.
DR Ensembl; ENSTNIT00000019997.1; ENSTNIP00000019767.1; ENSTNIG00000016660.1.
DR GeneTree; ENSGT00940000156318; -.
DR HOGENOM; CLU_003163_1_0_1; -.
DR InParanoid; H3DGX3; -.
DR OMA; DYRPDYR; -.
DR TreeFam; TF320666; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR46513:SF6; NIDOGEN-1; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 5.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1220
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003583429"
FT DOMAIN 107..270
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 412..644
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 643..684
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 685..727
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 734..777
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 778..814
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 821..894
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 963..1005
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1006..1048
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1049..1093
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 864..871
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 1220 AA; 133107 MW; F68270B2492FA784 CRC64;
QLLLKTRIMG RQERGWLVCL SFLGFVASVE SITRGELFPF GPSAGDQILA AGSDQTHRLE
LDSPVLFYDG TFDSIFVNTN GFVATAEPTG ESTYLGKMPS RFGMIAALQG DLDTSDEVGR
VYFRQDSSPE VLGRAAEHMN RAFPEDPAVS PTRAVIVTWA DVAPREPESR GDTLVRKRNT
FQLVIASTKN ASFAIVLYAN DGIQFTSTTV EGGVAILHAG FSKGIVQGFL FSSQGPYFRI
TTDEEESIRA LAEETNSGMQ GVWVYEIGTS PYFTNVAPGE VPYLPTEAPT PEIFEVDGGS
LGFDRGQQVE YPTFEPEGDQ IQVHPVQYQP GQPGNPEVLV VEDADIDVDA FPSVSSLRSC
TCPVFSYNLG TCASGRNTCS QYADCKDYSS GFCCHCRPGF YGNGIQCTAE GKPQRTNGKI
HGSVYVGNSP SPVQLTGNDL HSYVVVNEGR SYVAISEIPD SLGPSLQPLA AIGSAIGWAF
ALEQPGFKNG FSIIGGEFTR QVEVTFQPGN EKLTIRQEFK GIDEHDHLVM STTMDGRIPQ
VPYGATVKIE PYSEIYHYSS DLITSSSTRD YVVNLPDGSA DALTYQWRQT ITFRSCQHGD
AWRDVKPTQL LSVDGVLAMY DSNEVMRFTM TNKIGDVNGG EPEENPCFTG RHGCDTNAIC
RPEQGTQFTC QCAAGFNGDG HICYDVDECR EEPQICGFHA VCNNHPGTFR CECEDGYQFG
SDGRTCTASA LSRPVDACDE GTHTCDIQER ARCTYTGGSS YSCSCLPGFS GDGRTCQDID
ECQAGPCHRD AECYNNEGSF TCQCAPGYYG DGFLCTPERT KTRCQSHRES LLSVTEYGPR
GPRPSGGHYI PRCDENGAYE PTQCHGSSGY CWCVDRNGQE IPGTRSEPGS SPMCEGGLRP
PVGPTPRPDV HPLPPGTHLL FTQSGRIEHV PLEGSAMKKD DAKPVLHLPE KVVIGVAYDC
VEKMVYWTEI TSPSISKASM EGGDPVSVVR SDLGSPEGIA IDHLGRTVFW TDSVRDRIEV
ASLDGSQRRV IVDSDLVNPR AIVADPPSGN LFWTDWNRDA PKIETSYMDG SNRRVLVKDD
LGLPNGLTYD RHSFLLCWAD AGTHAMECMD PARGDRRKVA EGVRYPFAIT SLGNTVYYTD
WQREAVVAVD RHTGEETDQF QPQKRTKLYG LTTTYAQCPS GQNYCSVNNG GCTHLCLATP
LGRSCRCPND AASVGCVERD
//