ID H3DHA1_TETNG Unreviewed; 1477 AA.
AC H3DHA1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Coagulation factor VIII, procoagulant component {ECO:0000313|Ensembl:ENSTNIP00000019895.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019895.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019895.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC {ECO:0000256|ARBA:ARBA00010609}.
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DR Ensembl; ENSTNIT00000020125.1; ENSTNIP00000019895.1; ENSTNIG00000016782.1.
DR GeneTree; ENSGT00940000157994; -.
DR HOGENOM; CLU_000948_1_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd14452; CuRO_1_FVIII_like; 1.
DR CDD; cd00057; FA58C; 2.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 6.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR InterPro; IPR011707; Cu-oxidase-like_N.
DR InterPro; IPR011706; Cu-oxidase_C.
DR InterPro; IPR033138; Cu_oxidase_CS.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR024715; Factor_5/8-like.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR46806:SF7; COAGULATION FACTOR VIII; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07731; Cu-oxidase_2; 1.
DR Pfam; PF07732; Cu-oxidase_3; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR PIRSF; PIRSF000354; Factors_V_VIII; 2.
DR SMART; SM00231; FA58C; 2.
DR SUPFAM; SSF49503; Cupredoxins; 6.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR PROSITE; PS01285; FA58C_1; 2.
DR PROSITE; PS01286; FA58C_2; 2.
DR PROSITE; PS50022; FA58C_3; 2.
DR PROSITE; PS00079; MULTICOPPER_OXIDASE1; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR000354-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1477
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003583450"
FT DOMAIN 1164..1312
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 1318..1474
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 713..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 981..1007
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
FT DISULFID 1164..1312
FT /evidence="ECO:0000256|PIRSR:PIRSR000354-1"
SQ SEQUENCE 1477 AA; 166305 MW; 00415DEF10D0EB97 CRC64;
PGRAAMRTAT LPLLLPLLAC FCGGAAQQPP ALVRHVYIAA VEIGWDYIHV EDSDPGSEQR
KKPKDIPQKY IKAVYREYLD ATYTVPKPRP AWTGIQGPVI VAQAGHTVVV HFKNLASQPY
SISPVGISYW KHSEAGAGYD DATAGHEKED DAVDPGGYYK YVWDISPKDG PTSSDPECLT
YSYSSQVDPV RDVNSGLIGA LLICKTSAFT DEGQRRNQAF VLLFTVFDES KSWYGERSDG
RKEYHTINGY INATLPGLKM CQGRNPVMWH LIGMGTAEFH SIQFQDHTLE VLTHRKVTVE
VTPMTFITAE MKPATVGSFQ ISCQIHAHRD DGMSALFLVE KCPDPVPKQQ KLQARASRGR
SQVWEHYIAI EEITWDYAPH LKPTDSSELQ SRFFPTSSNH QNYKYKKAAY VEYTDGSFTR
KKNAEESLPK TVNLSNIKVV FGTSHANLIY SPPILFAIMC TKTYFQAVFR TAAETDLRSM
GVGPNQTFSY IWKLTTADGP LKGDPQCLTQ LYQSTVAPDR DLASGLVGTL LICKNEAIDM
RGRLLGSDKD WSLVFAVFDE NKSWYVNENI HNQTLAGCQG TDADVYDSNV IYSVSNNIMF
RKRQFVICQT DVAYWHVASA GAQKEFLSVY FTGNLFQHQG VYQSVLTLFP MSGMTVSMEP
EVVGEWEISA FDSSLKSRGM SIQYTVLTCE KDLLVDREID EDDISDYLDA LDLSPRGMRP
RSGKEDVNTT SGEKIPEDIL EELEIDGERR QAEDTRTRSG EEDREEGMEI QKQTLGNETN
TTFTTEKNGT KEELEEGNEI SLSGTPARSK ENSTSKMIIT EDMDLRSGEF RYPHYYIAAE
EVTWDYGIKK PHQLIKPREM NRGMRKFLPE YKKVVFRAYR DEGFQDPVSR GELQEHLGIL
GPFIRAEVDD LLTVIFKNKA SRPYSFHLHG VYDRKQAAGN TQSTSSAPPG VPGEPLAPGE
VRAYTWRITK TQGPTVSEFD CKTGTYYSTV DKERDLNSGL IGPLVICKPG TLSTRLQMQP
DIREFALLFH TFDETKSWYM EENLRRHCAP PSISLQVENV FAAINGYVAE SLPGLLVAQH
QQVRWHLLNV GSNGEYHAVH FHGLPFTVHT KNEHRMGVYN LFPGVFGTVE MRPPTVGTWL
VECTVGEIQQ AGMRAKLLVY NPQCSLPLGM KSGRIGDSQI TASDYIGSWL PHLARLDQSG
FVNAWMGQNK KSWIQVDLQK PTLLHGVLTQ GVRSKLRDNY ITFFTVSYSL DLETWSTYRG
SSSSRAKIFH GNLDNSRIKN NEFVPPFVAR YVRIHPVDYK QRPALRLELL GCDLQQGCSQ
PLGLQQGQIP DSSFIASSSY SSLWRRWLPE LARLHREGGA NAWRPKVNNN NPHEWLQVDL
GKVKRITGVV TQGARSMLTQ MMVTEFSVTV SHDSHVWSSV LEESSQREKI FPANNDPDEE
ALTIFDPPLF GRYIRIHPLG WINDIALRME VLGCDTQ
//
