ID H3DIP7_TETNG Unreviewed; 4113 AA.
AC H3DIP7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Dynein, cytoplasmic 1, heavy chain 1 {ECO:0000313|Ensembl:ENSTNIP00000020391.1};
GN Name=DYNC1H1 {ECO:0000313|Ensembl:ENSTNIP00000020391.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020391.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000020391.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 99883.ENSTNIP00000020391; -.
DR Ensembl; ENSTNIT00000020623.1; ENSTNIP00000020391.1; ENSTNIG00000017253.1.
DR GeneTree; ENSGT00940000156103; -.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; H3DIP7; -.
DR OMA; NERQMTR; -.
DR TreeFam; TF101165; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 2.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1743..1887
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2058..2276
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2392..2558
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2678..2719
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2868..2965
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4113 AA; 471530 MW; 39BC9DCE1BB58726 CRC64;
KSMSDGGGTE ESSGTMEVST VQTVADTSVL QKHIRKLVPL LLEDGGEAPA SLETALEEKS
AVEQMKKFLA DPQIHTILVE RSALKEEVGD EGEEEKECIT YNISIDIHYG LKSNSLALIK
RTGVIDADKP ISTQVRVLTL SEDSPYETLH SFISNAVAPF FKSYIRESGK ADRDGDKMAP
SVEKKIAELE MGLLHLQQNI EIPEISLLIH PNIANIAKQC YERGEKPKVT DFGDKVEDPT
FLNQLQSGVN RWIREIQKVT KLDRDPASGT ALQEISFWLN LERALNRIQE KRESPEVLLT
LDILKHGKRF HATVSFDTDT GLKQAVETVN DYNPLMKDFP LNDLLSALEL DKIRQALMAI
FTHLKKIRNT KYPIQRALRL VEAISRDLSS QLLKVLGTRK LMHVAYEEFE KVMVACFEVF
QTWEDEYEKL QVLLRDIVKR KREENLKMVW RLSPAHRKLQ SRLDHMRRFR RQHEQLRAVI
VRVLRPQVSA VPQHAPGETV EPQDLKVATV LFDAADANAI EEVNLAYENV KEVDGLDVSK
EGVEAWEAAM KRYDERIDRV ETRITARLRD QLGTAKNANE MFRIFSRFNA LFVRPHIRGA
IREYQTQLIQ RVKDDIESLH DKFKVQYPQS QACKMSHVRD LPPVSGSIIW AKQIDRQLTA
YMKRVEDVLG KGWENHVEGL KLKQDGDSFR AKLNTQEIFD DWARKVQQRN LGVSGRIFTI
ESTRARGRSG NMLKLKVNFL PEIITLSKEV RNLKWLSFRV PLAIVNKAHQ ANQLYPFAIS
LIESVRTYER TCEKVEERSS ISLLVAGLKK EVQALVTEGI TLVWESYKLD PYVQRLAETV
FNFQEKVDDL LLIEEKIDLE VRSLETCMFD HKTFSDILSR VQKAVDDLNL YSYSNLPIWV
NKLDIEIERI LGVRLQAGLK AWTQVLRGQV EDKADVDMDT EAPQVSHKPG GEPKIKNVVH
ELRITNQVIY LNPPIEDCRY KLYQEMFSWK MVILSLPRIQ SQRYQVGVHY ELSEEEKFYR
NALTRMPDGP AALEEAYNAV EDIVGEVEQY VKVWLQYQCL WDMQAENIYN RLGEDLTKWQ
ALLVQIRKAR GTFDNAETRK EFGPVVIDYG KVQSKVNLKY DSWHKEVLSK FGQMLGQNMQ
DFHAQISKSR QELEQHSVDT ASTSDAVNFI TYVQTLKRKI KQFEKNVDVI RNGQRLLEKQ
RFQFPPSWLY IDNIEGEWGA FSDIMKRKDT AIQQQVANLQ MKIVQEDKAV ENRTTDLLND
WEKTKPVAGN LRPEEALQSL TIYEGNFSRL KDEREKCARA KEALELTDTG VFSGSEERVQ
VALEELHDLK EVWSELSKVW EQIDQMKEQP WVSVQPRKLR QSLDALLNQL KNFQARLRQY
ASYEYVQRLL KGYLKVSDIK HLLPVETQRF QSISTEFLAL MKKVSKSPLV MDVLNIQGVQ
RSLERLADLL GKIQKALGEY LERERSSFPR FYFVGDEDLL EIIGNSKNVA KLQKHFKKMF
AGVSSILLNE DNTEVLGISS REGEEILYKT PVSITEHPKI NEWLTLVEKE MRVTLAKLLA
ESVTEVTSFN KGTAVDLSQY ITWIDRYQAQ LVVLSTQIAW SENIESALTT ISGGGDMTLM
QAVLSNVEAT LNVLADTVLM EQPPLRRRKL EHLITELVHQ RDVTRTLIKN KIDNPKSFEW
LSQMRFYFDP KQTDVLQQLS IQMANAKFNY GFEYLGVQDK LVQTPLTDRC YLTMTQALEA
RLGGSPFGPA GTGKTESVKA LGHQLGRFVL VFNCDETFDF QAMGRIFVGL CQVGAWGCFD
EFNRLEERML SAVSQQVQYI QVALREHSNP NRDRIFIGVP VTTELLNKMK VSPDMAIFIT
MNPGAGRSNL PDNLKKLFRS LAMTKPDRQL IAQVMLYSQG FRTAEVLAKK IVPFFKLCDE
QLSSQSHYDF GLRALKSVLI SAGNVKRERI QRIKKDKLER GEDVDENEIA ENLPEQEILI
QSVCETMVPK LVAEDIPLLF SLLSDVFPGI QYQRGEMTAL REELKKVCGE MYLTYGDGDE
VGSMWVEKVL QLYQITQINH GLMMVGPSGS GKTMAWRVLL KALERLEGVE GVAHIIDPKA
ISKDHLYGTL DPNTREWTDG LFTTFSESEM KIALKKKKDI FNFMSSQMLN MLTKFHKNTI
KTSRNGGKET ATHRKFRTPL KGCPDVLFRF LRHVPVVYVD YPGPASLTQI YGTFNRAMLR
LIPSLRTYAE PLTAAMVEFY TMSQERFTQD TQPHYIYSPR EMTRWVRGIF EALRPLETLP
VEGLIRIWAH EALRLFQDRL VGDDERRWTD ENIDMVALKH FPNIDKDKAL NRPILYSNWL
SKDYIPVEQE ELRDYVKARL KVFYEEELDV PLVLFNEVLD HVLRIDRIFR QPQGHLLLIG
VSGAGKTTLS RFVAWMNGLS VYQIKVHRKY TGEDFDEDLR TVLRRSGCKN EKIAFIMDES
NVLDSGFLER MNTLLANGEV PGLFEGDEYA TLMTQCKEGA QKEGLMLDTH EELYKWFTSQ
VIRNLHVVFT MNPSSEGLKD RAATSPALFN RCVLNWFGDW STEALYQVGK EFTSKMDLEK
PNYKVPDYMP IVYDKLPQPP SHREAIVNGC VFVHQTLHQA NNRLAKRGGH TMAITPRHYL
DFINQYANLF NEKRSELEEQ QMHLNVGLRK IKETVDQTKK VEELRRDLRI KSQELEAKNA
AANDKLKKMV KDQQEAEKKK VVSQEIQEAV YKQQEVIKDK QQSVKHDLDQ VEPAVIEAQN
AVKSIKKQHL VEVRSMANPP AAVKLALESI CLLLGESTVD WKQIRSIIMR ENFIPTIVNF
SADEISDSIR EKMKKNYLSN PGYNYDQINR ASLACGPMVK WAIAQLNYAD MLKRVEPLRN
ELQKLEDDAT DNKTKAEEVE QMIRDLEASI ARYKEEYAVL ISEAQAIKAD LAAVEAKVNR
STALLKSLSA ERDRWEKTSE TFKNQMSTIA GDCLLSAAFI TYAGYFEQQM RQNLFTTWSH
HLQQANIQFR TDIARTEYLS NADERLRWQA NSLPADDLCT ENAIMLKRFN RYPLIIDPSG
QATEFIMNEY KDRKITRTSF LDDAFRKNLE SALRFGNPLL VQDVESYDPI LNPVLNREVR
RTGGRVLITL GDQDIDLSPS FVIFLSTRDP TVEFPPDLCS RVTFVNFTVT RSSLQSQCLN
EVLKAERPDV DEKRSDLLKL QGEFQLRLRQ LEKSLLQALN EVKGRILDDD TIITTLENLK
KEAAEVTRKV EETDIVMAEV ETVSQQYLTL SSACSSIYFT MEALNQMHFL YQYSLHFFLD
TYHTVLYENP NLKSISDHSQ RLAVLTKDLF QVVFNRAARG MLHLDHITFA MLLAKISLKG
MTSEPSYDSE FQHFLRGKEI VLTGTSLPKV KGLSSEQSEA MVRLSRLPAF SDLVNKVQAD
EQFFMWIESN TPELAVPYLW SEEKQSTPIG QAVHQLLLIQ AFRPDRLLAM SHIFVAKVLG
ESFMSIIEQP LDLANVVENE VKPSTPVLMC SVPGYDASGL VRDLAAEENR QITSISIGSA
EGFNKADKDI NTAVKSGRWV MLENVHLAPA WLMHLEKKLH SMHPHACFRL FLTMEINPKV
PVNLLRAGRI FVFEPTPGVK ANMLRTFSSI PVARMCKAPN ERARLYFLLA WFHAVIQERL
RYAPLGWSKK YEFGESDLRS ACDTVDTWLD DTAKGRQNIA PDKIPWAALK TLMAQSIYGG
RIDNDFDQRL LNTFLDRIFT KGSFDSEFKL ALKVDGHKDL KMPDGIRREE FMHWVEMLPD
TQTPSWLGLP SNAEKVLLTT QGTDMMGKML KMQMLEDEDD LAYETEKKER TSSTSDTQPA
WMRTLHTTAC NWLQLMPQSV NPLKRTVENI KDPLFRFFER EVKMGGKMLQ DVRQDLSDVV
QVCQGKKKQT NYLRTLISDL VKGILPRSWC RYTVPASMTV IQWVADFSER IKQLQMISQG
AATGGAKELK NIHVCVGSLF VPEAYITATR QYVAQANSWS LEELCLEVNV TTAQGASLDA
CSFGIKGLKL QGATCANNKL SLSTTISTEL PLTQLRWIKH SSTEKRHTVK QVTLPVYLNF
TRSDLIFTVD FDIATKEDPH SFYERGVAVL CNE
//
