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Database: UniProt
Entry: H3DJ90_TETNG
LinkDB: H3DJ90_TETNG
Original site: H3DJ90_TETNG 
ID   H3DJ90_TETNG            Unreviewed;      4919 AA.
AC   H3DJ90;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 50.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTNIP00000020586};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSTNIP00000020586};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020586, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000020586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000020586}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 99883.ENSTNIP00000020586; -.
DR   Ensembl; ENSTNIT00000020818; ENSTNIP00000020586; ENSTNIG00000017445.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H3DJ90; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4243   4263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4462   4482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4525   4548       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4721   4742       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4796   4819       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    217       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      225    279       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      285    348       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      350    407       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      609    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1023   1220       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1323   1522       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3993   4019       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3464   3484       {ECO:0000256|SAM:Coils}.
FT   COILED     3661   3684       {ECO:0000256|SAM:Coils}.
FT   COILED     4172   4195       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4919 AA;  558412 MW;  0F5A4F14E51D3431 CRC64;
     TWTRSRMPVF CPDRMMKWCS SVWPVSRRRI ASFAWLLRGW ATACVTWNPH PRRSMFLQTC
     ASAPLCWSSR CRSGLCKRCW MLETVRTQRG ALNISIWAYQ YLQAAHSGGH KTLLYGHAIL
     LRHSFSSMYL ACLKTSRSQT DKLSFDVGLQ EDSTGEACWW TIHPASKQRS EGEKVRIGDD
     LILVSLSSER YLHLSISNGN IQVDASFMQT LWNVHPICSG SNIEEGYLLG GHVIRLFHGH
     DEVVAIPGSD QSEEEQRIVN YETGKAGAKA RSLWRLEPLR ISWSGSHIRW GQPFRLRHLT
     TGHYLALTED RGLVLQDRER SDTDATAFCF RASKEKLEQS PKRDIEGMGV AEIKYGDSLC
     FVMHVATGLW LSYQAPDVKS ARLGPLKRRA CLHTEGHMDD GLTLQRCQHE ESRAARIIRN
     TTLLFNRFVR DLDCLGVKNR AVVFLPVEEV LQTLNDLIAY FQLPDVELEH EERQIKLRSL
     KNRQNLFKQE GMLNLVSNCI DRLNVYNSAA HFGECAGHEA GAAWKDILNL LYELLAALIR
     GNRNNCTQFS NNLDWLVSKL ERLESSSGIL EVLHCILIES PEALNIIQRG HIKSIISLLY
     KHGRNHKILD VLCSLCVCNG VAVRTNQNLI CDHLLPKRDL LLQSQLVNDV QSMRPNIFLG
     VSEGSAQYKK WYYELMIDQV DHFVTSEPTH LRVGWANTKG YAPYPGGGEG WGGNGVGDDL
     YSFAFDGLHL WSGRVPRAVA SLNQHILTSE DVVSCCLDLG APSISFRING QPVQGMFENF
     NTDGLFFPVV SFSAGVKVRF LLGGRHGDFK FLPPSGYAPC YEALLPKEKM KVEPVKEYKR
     DVGGVRDLLG TAQLLSQASF IPTPVETSQI IMPPHLEKVR DKLAENIHEL WGMNKIELGW
     TYGKIRDDNK RQHPCLVDFS KLPETEKNYN LQMSTETLKT LLALSCRVVQ VNSNAENALK
     KIKLTKNYMM SNGYKPTPLD LSDIKLTPGQ EMLVDKLAEN AHNVWAKDRI KQGWTYGIQQ
     DLKSKRNPRL VPYVLLDERT KKSNRDSLRE AIRTLIGYGY NIEPSDQEGR SGQTVERISI
     DKVRFFRVER TYAVKTGKWY FEFEAVTGGD MRVGWARPGC KPDVELGTDA HAFVFDGYRG
     HCLHTGSRLF GRCWHAGDVV GCMINMQDKS MIFTLNGEIL ITTKGSELCF TDFDAEDGFI
     PVCSLGLAQV GRMNLGKDAS TFKYYTMCGL QEGFEPFAVN MNREVTMWFS KRLPTFINVP
     KDHNHIAVTR IDGTIDSPPC LKVSHKTFGS QNSNADMVFC RLSMPIEFHS AFKHSPIADV
     NGIHEEDVLK VKHRSASGFT HNMFVDCTHE INTFMSYRYP LRSVRHSDES RRVDYSSITT
     VTSHYYHSVR VFAGQDPAGV WVGWVTPDYH YYSNNFNLGK NRTVTVTLGD ERGRVHEERD
     SVKRSNCYMV WGGDATSAVR SNVDLEIGCL IDLATGLVTF TINGKEMSSS YQVEPNTKLF
     PAVFVRPTSA NLFQFELGKI KNAMPLSSAI FKSEHKNPIP QCPPRLDVQT ISAVLWSRMP
     NNFLKVDTAR VSERHGWVVQ CVEPLQMLAV HIPEENRCVD IMELSEQEDL RKFHFHTLKL
     YCALCALGNT RVAHALCSHL DQSQLLYTID NQYLSGMLRE GCYNVLISIH LETAKEARLM
     MKDEFIIPVT PETRSIRLFF DASKKHRPPG VGLSTSLKPR FNFAPPCFIS TKQEQHLYSP
     QVPLNTLKEK AISMLTEAVQ GGGHHIRDPV GGCVEYQFVP ILKLISTLLT MGVLASEDVH
     QILLLIDPNV FRETREEGNT GATDKEGFAG AVDKAVEAGE EEAAKEAKQP LKGLLEKRLP
     EPVKRQMCEL LHYFCDCELK HRIEAIVSFS DNFVSKLQFN QKFRYNELML ALNMSAAVTA
     KKTKEFRSPP QEQINMLLTF STGDDCPCPS DIQEELYDFH NQLQLHCGIP MEEDEDEHHT
     SIRGRLLMLV NKIKGQAHRA EEPMEKEQAA PSNLKELISQ TMVSWAQECH IQDPQLVRKM
     FSLLRRQYDS IGELLRAMRK TYTISASSVQ DTINLLASLG QIRSLLSVRM GKEEEKLMID
     GLGDIMNNKV FYQHPNLMRI LGMHETVMEV MVNVLGGDKS QEIAFPKMVA SCCRFLCYFC
     RISRQNQKAM FDHLSYLLEN SSVGLASPAM RGSTPLDVAA SSVMDNNGLA LALEEPDLEK
     VVTYLAGCGL QSCPMLLAKG YPDIGWNPIE GERYLSFLRF AVFVNGESVE ENSSVVVKLL
     IRRPECFGPA LRGEGGNGLL AAMKEAIKIS ETPALDLPGS VHGVCADVSA DGDDEEEVVH
     MGNAIMSFYS ALIDLLGRCA PEMHLLNKGK GEALRIRAIL RSLVPTEDLV GIISIPLKMP
     IINKDCSVTE PDMSACFCPD HKAPMVLFLD RVYGIEDQSF LLHLLEVGFL PDLRAATSLD
     TEGLCTTETA LAMNRYIGSA LLPLLTRCAP LFAGTEHYAS LIDSTLHTIY RLSKGRSLTK
     AQRDAIEECL LAVCKHLRPS MLQQLLRRLV FDVPLLTEYC KMPLRLLTNH YEQNWKYYCL
     PSGWGSYGTA SEDELLLTKK LFWGIFDSLS QRKYDPELFK MAMPCLSAIA GALPPDYVDA
     SISTIVEKPI SVDAQGNFDP KPISTASVSL PEKLEHFANK YGEHLHEKWS AEKVLLGWKY
     GDSLDEKAKI HPQLRIYKSL TEKEKEIYRW PVRETLKSML AMGWSIDRTK DGESMSQQRE
     NEKLRKISQV SQVNSQVANG FNPSPTDTSN VVLSRELQGM VEVVAENYHN IWAKKKKSDL
     GSRGGGPHPL LVPYDTLTAK EKARDREKAQ DLFRFLQING YSITRGLKDL EQDSSSMEKR
     FAYRFLKKLL KYVDSAQEFI AHLALALEAM AASGKTDRSP HEQEIKFFAK VLLPLIDQYF
     KNHCLYFLSS PNKNLSSSGY ASNKEKEMVT SLFCKLAALV RHRISLFGSD STTIVSCLHI
     LAHTLDTRTV MKSGSELVRV GLRTFFENAA EDLEKTFENL KLGKFTHSRS QMKGVSQNIN
     YTTVALLPIL TALFEHITQH HFGADLLLED VQVSCYRILT SLYALGTGKN IYVERQLPAL
     GQCLATLAGA MPVAFLEPLL NTYNPCSVFN TKSARERAIL GIPSSVEEMC PGMPRLDGLM
     KDINDMAESG ARYTEMPHVI EVVLPMLCNY LSYWWEKGPE NQLASGGGIC CTTVTSEHLS
     VILGNILKIL NNNLGIDEAS WMKRIAVYVQ PIISKARADL LRSHFLPTLE KLKKKTVKVV
     SEEELLKADG RGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSRW LKEPDADSNE
     LFRMVAEIFI LWCKSHNFKR EEQNFVVQNE INNLSFLTGD NKTKMSKSGG QDQERRHKKR
     RGEFYSVQTS LIVAALKKML PIGLNMCTPG DQELISLAKM RYLLKDTDEE VKDHIQQNLH
     LREKSEDPAV RWQLNLYRDR ALRFEGPPDP EKVLDRIQRI SAAVFNLEQV GLYFFVEQPL
     RSKKCVWQKL LSKQRKRAVV ACFRMAPLYN LPRHRSINLF LQAYQRIWIE TEEYSFEEKL
     VQDLAKIQPK IEEEEEEEVR KQPDPLHQLI LHFSHNALTE CSSLEEDPLY IAYADMMAKS
     CAEGEEEEEE KEKTFEEKEM EKQKMLYQQA RLHDRGAAEM VLQMISASKG RLGAMVTVTL
     KLGISILNGG NILVQQKMLD YLKEKRDVGF FKSLSGLMMS CSVLDLNAFE RQNKAEGLGM
     VTEEGSSSKV LQDDEFTKDL FRFLQLLCEG HNNDFQNFLR TQTGNTTTVN IIISTVDYLL
     RLQESISDFY WYYSGKDVID EAGQRNFSRA LAVAKQVFNS LTEYIQGPCV GNQQSLAHSR
     LWDAVVGFLH VFANMQMKLS QDSSQIELLK ELLDLQQDMI VMMLSLLEGN VVNGTIGKQM
     VDTLVESSSN VEMILKFFDM FLKLKDLTTS DSFKEYDPEN KGVISKKDFQ KSMENQKQYS
     QSEIEFLLSC AEADENDMFN YKQFVDRFHE PAKDIGFNVA VLLTNLSEHM PHDARLSTFL
     DLAESVLSYF EPYLGRIEIM GGAKRIERVY FEISESSRTQ WEKPQVESKR QFIFDVVNER
     GESEKMELFV NFCEDTIFEM QLASQISEPD PVERAEEDED DGQSVQENQE EEEEQSVLLE
     SSSAFTVACI SMRKSLCHFR QLLTLRSLRR QYRTFRKMTV REMVQGFFSF FWIIITGFLH
     FFYSLVWGFF HILWTTMFGG GFVEGAKNMK VTDILGNMPD PTQFGIHGDV LELEKIEANE
     ASALADIGQM SQGDAAEAAL MAELLNVQPR KEGKHGSEPG LGDVSEVVVG DAPSIASAVK
     QKKAQMAAKK TASNGEHKSD LEKVDSEYGE KNDHGSSVEE KKAPKKRLGQ RKEPPEAFMA
     SFFASVEIYQ TKILNYLARN FYNLRFLALF VAFAINFILL FYKVTGDYSD EEDLWNGRRR
     TGGEEEEEGA LEYFILQEST GYMAPALRCL AILHTIISFL CVVGYYYLKV PLVVFKREKE
     IARKLEFAGL YITEQPSDDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIK KYGDLYGAER
     IAELLGLDKS ALDFNPTEET VTKEASLVSW LSSIDTKYHV WKMGVVFTDN SFLYLVWYTT
     MSILGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN
     FFRKYNKSED EDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDP YELYRILFDI
     TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGNDYF DTTPHGFETH
     TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
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