GenomeNet

Database: UniProt
Entry: H3DJ91_TETNG
LinkDB: H3DJ91_TETNG
Original site: H3DJ91_TETNG 
ID   H3DJ91_TETNG            Unreviewed;      4907 AA.
AC   H3DJ91;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 53.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTNIP00000020587};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSTNIP00000020587};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020587, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000020587}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000020587}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSTNIT00000020819; ENSTNIP00000020587; ENSTNIG00000017445.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4223   4243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4450   4470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4513   4536       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4709   4730       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4784   4807       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    141       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      148    193       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      201    255       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      261    324       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    783       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      999   1194       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1297   1498       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3973   3999       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3444   3464       {ECO:0000256|SAM:Coils}.
FT   COILED     3635   3658       {ECO:0000256|SAM:Coils}.
FT   COILED     4152   4175       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4907 AA;  556143 MW;  C81612CFFC4E5DE0 CRC64;
     RQDDEVVLQC VACIQKENRK FCLAAEGLGN RLCYLEPTSE AKYVPPDLCI CTFVLEQSLS
     VRALQEMLAN SGQNSEGLQA AHSGGHKTLL YGHAILLRHS FSSMYLACLK TSRSQTDKLS
     FDVGLQEDST GEACWWTIHP ASKQRSEGEK VRIGDDLILV SLSSERYLHL SISNGNIQVD
     ASFMQTLWNV HPICSGSNIE EGYLLGGHVI RLFHGHDEVV AIPGSDQSEE EQRIVNYETG
     KAGAKARSLW RLEPLRISWS GSHIRWGQPF RLRHLTTGHY LALTEDRGLV LQDRERSDTD
     ATAFCFRASK EKLEQSPKRD IEGMGVAEIK YGDSLCFVMH VATGLWLSYQ APDVKSARLG
     PLKRRACLHT EGHMDDGLTL QRCQHEESRA ARIIRNTTLL FNRFVRDLDC LGVKNRAVVF
     LPVEEVLQTL NDLIAYFQLP DVELEHEERQ IKLRSLKNRQ NLFKQEGMLN LVSNCIDRLN
     VYNSAAHFGE CAGHEAGAAW KDILNLLYEL LAALIRGNRN NCTQFSNNLD WLVSKLERLE
     SSSGILEVLH CILIESPEAL NIIQRGHIKS IISLLYKHGR NHKILDVLCS LCVCNGVAVR
     TNQNLICDHL LPKRDLLLQS QLVNDVQSMR PNIFLGVSEG SAQYKKWYYE LMIDQVDHFV
     TSEPTHLRVG WANTKGYAPY PGGGEGWGGN GVGDDLYSFA FDGLHLWSGR VPRAVASLNQ
     HILTSEDVVS CCLDLGAPSI SFRINGQPVQ GMFENFNTDG LFFPVVSFSA GVKVRFLLGG
     RHGDFKFLPP SGYAPCYEAL LPKEKMKVEP VKEYKRDVGG VRDLLGTAQL LSQASFIPTP
     VETSQIIMPP HLEKVRDKLA ENIHELWGMN KIELGWTYGK IRDDNKRQHP CLVDFSKLPE
     TEKNYNLQMS TETLKTLLAL SCRVVQVNSN AENALKKIKL TKNYMMSNGY KPTPLDLSDI
     KLTPGQEMLV DKLAENAHNV WAKDRIKQGW TYGIQQDLKS KRNPRLVPYV LLDERTKKSN
     RDSLREAIRT LIGYGYNIEP SDQEGSQTVE RISIDKVRFF RVERTYAVKT GKWYFEFEAV
     TGGDMRVGWA RPGCKPDVEL GTDAHAFVFD GYRGHCLHTG SRLFGRCWHA GDVVGCMINM
     QDKSMIFTLN GEILITTKGS ELCFTDFDAE DGFIPVCSLG LAQVGRMNLG KDASTFKYYT
     MCGLQEGFEP FAVNMNREVT MWFSKRLPTF INVPKDHNHI AVTRIDGTID SPPCLKVSHK
     TFGSQNSNAD MVFCRLSMPI EFHSAFKHSP IADVNGIHEE DVLKVKHRSA SGFTHNMFVD
     CTHEINTFMS YRYPLRSVRH SDESRRVDYS SITTVTSHYY HSVRVFAGQD PAGVWVGWVT
     PDYHYYSNNF NLGKNRTVTV TLGDERGRVH ERDSVKRSNC YMVWGGDATS AHASSRSNVD
     LEIGCLIDLA TGLVTFTING KEMSSSYQVE PNTKLFPAVF VRPTSANLFQ FELGKIKNAM
     PLSSAIFKSE HKNPIPQCPP RLDVQTISAV LWSRMPNNFL KVDTARVSER HGWVVQCVEP
     LQMLAVHIPE ENRCVDIMEL SEQEDLRKFH FHTLKLYCAL CALGNTRVAH ALCSHLDQSQ
     LLYTIDNQYL SGMLREGCYN VLISIHLETA KEARLMMKDE FIIPVTPETR SIRLFFDASK
     KHRPPGVGLS TSLKPRFNFA PPCFISTKQE QHLYSPQVPL NTLKEKAISM LTEAVQGGGH
     HIRDPVGGCV EYQFVPILKL ISTLLTMGVL ASEDVHQILL LIDPNVFRET REEGNTGATD
     KEGFAGAVDK AVEAGEEEAA KEAKQPLKGL LEKRLPEPVK RQMCELLHYF CDCELKHRIE
     AIVSFSDNFV SKLQFNQKFR YNELMLALNM SAAVTAKKTK EFRSPPQEQI NMLLTFSTGD
     DCPCPSDIQE ELYDFHNQLQ LHCGIPMEED EDEHHTSIRG RLLMLVNKIK GQAHRAEEPM
     EKEQAAPSNL KELISQTMVS WAQECHIQDP QLVRKMFSLL RRQYDSIGEL LRAMRKTYTI
     SASSVQDTIN LLASLGQIRS LLSVRMGKEE EKLMIDGLGD IMNNKVFYQH PNLMRILGMH
     ETVMEVMVNV LGGDKSQEIA FPKMVASCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG
     LASPAMRGST PLDVAASSVM DNNGLALALE EPDLEKVVTY LAGCGLQSCP MLLAKGYPDI
     GWNPIEGERY LSFLRFAVFV NGESVEENSS VVVKLLIRRP ECFGPALRGE GGNGLLAAMK
     EAIKISETPA LDLPGSVHGV CADVSADGDD EEEVVHMGNA IMSFYSALID LLGRCAPEMH
     LLNKGKGEAL RIRAILRSLV PTEDLVGIIS IPLKMPIINK DCSVTEPDMS ACFCPDHKAP
     MVLFLDRVYG IEDQSFLLHL LEVGFLPDLR AATSLDTEGL CTTETALAMN RYIGSALLPL
     LTRCAPLFAG TEHYASLIDS TLHTIYRLSK GRSLTKAQRD AIEECLLAVC KHLRPSMLQQ
     LLRRLVFDVP LLTEYCKMPL RLLTNHYEQN WKYYCLPSGW GSYGTASEDE LLLTKKLFWG
     IFDSLSQRKY DPELFKMAMP CLSAIAGALP PDYVDASIST IVEKPISVDA QGNFDPKPIS
     TASVSLPEKL EHFANKYGEH LHEKWSAEKV LLGWKYGDSL DEKAKIHPQL RIYKSLTEKE
     KEIYRWPVRE TLKSMLAMGW SIDRTKDGES MSQQRENEKL RKISQVSQVN SQANGFNPSP
     TDTSNVVLSR ELQGMVEVVA ENYHNIWAKK KKSDLGSRGG GPHPLLVPYD TLTAKEKARD
     REKAQDLFRF LQINGYSITR GLKDLEQDSS SMEKRFAYRF LKKLLKYVDS AQEFIAHLAL
     ALEAMAASGK TDRSPHEQEI KFFAKVLLPL IDQYFKNHCL YFLSSPNKNL SSSGYASNKE
     KEMVTSLFCK LAALVRHRIS LFGSDSTTIV SCLHILAHTL DTRTVMKSGS ELVRVGLRTF
     FENAAEDLEK TFENLKLGKF THSRSQMKGV SQNINYTTVA LLPILTALFE HITQHHFGAD
     LLLEDVQVSC YRILTSLYAL GTGKNIYVER QLPALGQCLA TLAGAMPVAF LEPLLNTYNP
     CSVFNTKSAR ERAILGIPSS VEEMCPGMPR LDGLMKDIND MAESGARYTE MPHVIEVVLP
     MLCNYLSYWW EKGPENQLAS GGGICCTTVT SEHLSVILGN ILKILNNNLG IDEASWMKRI
     AVYVQPIISK ARADLLRSHF LPTLEKLKKK TVKVVSEEEL LKADGRGDTQ EAELLILDEF
     AVLCRDLYAF YPMLIRYVDN NRSRWLKEPD ADSNELFRMV AEIFILWCKS HNFKREEQNF
     VVQNEINNLS FLTGDNKTKM SKVGFKQSGG QDQERRHKKR RGEFYSVQTS LIVAALKKML
     PIGLNMCTPG DQELISLAKM RYLLKDTDEE VKDHIQQNLH LREKSEDPAV RWQLNLYRDR
     ALRFEGPPDP EKVLDRIQRI SAAVFNLEQV EQPLRSKKCV WQKLLSKQRK RAVVACFRMA
     PLYNLPRHRS INLFLQAYQR IWIETEEYSF EEKLVQDLAK IQPKIEEEEE EEVRKQPDPL
     HQLILHFSHN ALTECSSLEE DPLYIAYADM MAKSCAEGEE EEEEKEKTFE EKEMEKQKML
     YQQARLHDRG AAEMVLQMIS ASKGRLGAMV TVTLKLGISI LNGGNILVQQ KMLDYLKEKR
     DVGFFKSLSG LMMSCSVLDL NAFERQNKAE GLGMVTEEGS ILSQSSGSKV LQDDEFTKDL
     FRFLQLLCEG HNNDFQNFLR TQTGNTTTVN IIISTVDYLL RLQESISDFY WYYSGKDVID
     EAGQRNFSRA LAVAKQVFNS LTEYIQGPCV GNQQSLAHSR LWDAVVGFLH VFANMQMKLS
     QDSSQIELLK ELLDLQQDMI VMMLSLLEGN VVNGTIGKQM VDTLVESSSN VEMILKFFDM
     FLKLKDLTTS DSFKEYDPEN KGVISKKDFQ KSMENQKQYS QSEIEFLLSC AEADENDMFN
     YKQFVDRFHE PAKDIGFNVA VLLTNLSEHM PHDARLSTFL DLAESVLSYF EPYLGRIEIM
     GGAKRIERVY FEISESSRTQ WEKPQVESKR QFIFDVVNER GESEKMELFV NFCEDTIFEM
     QLASQISEPD PVERAEEDED DGQSVQENQE EEEEQSVLLE SSSAFTVACI SMRKSLCHFR
     QLLTLRSLRR QYRTFRKMTV REMVQGFFSF FWIIITGFLH FFYSLVWGFF HILWTTMFGG
     GFVEGAKNMK VTDILGNMPD PTQFGIHGDV LELEKIEANE ASALADIGQM SQGDAAEAAL
     MAELLNVQPR KEGKHGSEPG LGDVSEVVVG DAPSIASAVK QKKAQTDGQQ TCVSPPQKYN
     CCCSSEYGEK NDHVRTKDEA PQGSSVEEKK APKKRLGQRK EPPEAFMASF FASVEIYQTK
     ILNYLARNFY NLRFLALFVA FAINFILLFY KVTGDYSDEE DLWNGRRRTG GEEEEEGALE
     YFILQESTGY MAPALRCLAI LHTIISFLCV VGYYYLKVPL VVFKREKEIA RKLEFAGLYI
     TEQPSDDDIK GQWDRLVINT PSFPNNYWDK FVKRKVIKKY GDLYGAERIA ELLGLDKSAL
     DFNPTEETVT KEASLVSWLS SIDTKYHVWK MGVVFTDNSF LYLVWYTTMS ILGHYNNFFF
     AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKYNKSEDED
     EPDMKCDDMM TCYLFHMYVG VRAGGGIGDE IEDPAGDPYE LYRILFDITF FFFVIVILLA
     IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT TPHGFETHTL QEHNLANYLF
     FLMYLINKDE TEHTGQESYV WKMYQERCWD FFPAGDCFRK QYEDQLG
//
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