ID H3DKB5_TETNG Unreviewed; 1540 AA.
AC H3DKB5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 18-JUN-2025, entry version 69.
DE SubName: Full=Ankyrin 2a, neuronal {ECO:0000313|Ensembl:ENSTNIP00000020961.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020961.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000020961.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma, T-tubule
CC {ECO:0000256|ARBA:ARBA00024012}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034100}.
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DR Ensembl; ENSTNIT00000021194.1; ENSTNIP00000020961.1; ENSTNIG00000017807.1.
DR GeneTree; ENSGT00940000155279; -.
DR HOGENOM; CLU_000134_7_1_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR FunFam; 1.25.40.20:FF:000003; Ankyrin, isoform B; 1.
DR FunFam; 1.25.40.20:FF:000001; Ankyrin-2 isoform 2; 1.
DR FunFam; 1.25.40.20:FF:000002; Ankyrin-2 isoform 2; 1.
DR FunFam; 1.10.533.10:FF:000002; Ankyrin-3 isoform 2; 1.
DR FunFam; 2.60.220.30:FF:000001; Ankyrin-3 isoform 2; 1.
DR FunFam; 2.60.220.30:FF:000002; Ankyrin-3 isoform 2; 1.
DR FunFam; 2.60.40.2660:FF:000001; Ankyrin-3 isoform 2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_dom.
DR InterPro; IPR051165; Multifunctional_ANK_Repeat.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR PANTHER; PTHR24123:SF49; ANKYRIN-2-LIKE ISOFORM X1; 1.
DR Pfam; PF00023; Ank; 5.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 58..90
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 91..123
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 124..156
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 157..180
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 219..251
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 252..284
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 285..317
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 318..350
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 351..383
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 384..416
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 417..449
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 450..482
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 483..515
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 516..548
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 549..581
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 582..614
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 615..647
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 648..680
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 681..713
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 714..746
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 747..779
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 965..1120
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1122..1270
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1459..1540
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1540 AA; 169393 MW; 4903EB6A6762AB03 CRC64;
RAREKRRQQR ERAERKRQSS HLQSDSNTSF LRAARAGNID KVLDFLKNGI DISTCNQNGL
NALHLAAKEG HKDLVEELLD RGAPVDSSTK KGNSALHIAS LAGQKEVVRL LVKRGANINS
QSQNGFTPLY MAAQENHLEV VRYLLENDGN QSIATEDGFT PLAIALQQGH NSVVSLLLEH
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKSG FTPLHIAAHY GNVNVSTLLL
NRGAAVDFTA RNGITPLHVA SKRGNTNMVA LLLDRGAQID AKTRDGLTPL HCAARSGHDQ
AVEILLDRGA PILARTKNGL SPLHMSAQGD HIECVKLLLQ HQAPVDDVTL DYLTALHVAA
HCGHYRVTKL LLDKKANPNV RALNGFTPLH IACKKNRVKV MELLVKYGAS IQAITESGLT
PIHVAAFMGH LSIVLLLLQN GASPDIRNIR GETALHMAAR AGQMEVVRCL LRNGALVDAM
AREDQTPLHI ASRLGKTDIV QLLLQHMAHP DAATTNGYTP LHISAREGQL ETAAVLLEAG
ASHSLPTKKG FTPLHVAAKY GNLDVAKLLL QSKALPDDAG KNGLTSLHVA AHYDNQDVAL
LLLDKGASPH STAKNGYTPL HIAAKKNQTK IASALLQYGA ETNILTKQGV SPLHLAAQEG
HTEMTGLLLD KGAHVNAATK SGLTPLHLTA QEDKVGAAEV LAKYDANLDQ QTKLGYTPLI
VACHYGNAKM VNFLLQQGAS VNAKTKNGYT PLHQAAQQGN THIINVLLQH GAKPNTTTMS
GNTALSIARR LGYISVVDTL KVVTEEVITT TTTVTEKHKL NVPETMTEVL DVSDEEALKL
EDEPLTEMSV ELEGEDTMTG DGGEYLRAED LRDLGDDSLP GHYLDFRQVE IGQTDKQMRR
FGTSQHTPIH QSFTQREGFF IEDMLTSHQV SVLSKEHEKD SFRLSWGAEH LDNVVLSSSL
LHSGFLVSFM VDARGGAMRG CRHNGLRIIV PPRKCSAPTR VTCRLVKRHR LASMPPMVEG
EGLAGRIIEV GPTGAQFLGP VIVEIPHFAA LRGTERELVI LRSETGESWR EHHCDFTEEE
LNQILNGMDE KLDSPEELEK KRICRIITRD FPQYFAVVSR IKQDSHLIGP EGGVLSSTLV
PQVQAVFPEG ALTKKIRVGL QAQPIDGDVV KKILGNKAAF SAIVTLEPRR RKFHKPITMT
IPIPKSPNTE GPTSEFSGET PTLRLLCSIT GGTTPAQWED ITGSTPLTFV NHCVSFTTNV
SARFWLIDCR QVQESVSFAS QLYREIICVP YMAKFVIFAK TLDPIEARLR CFCMTDDKMD
KTLEQQENFT EVARSRDVEV LEGKPIFVDC FGNLVPLTKS GQHHVFSFFA FKENRLALFI
KIRDTAQEPC GRLSFTKEAR TYRSLTHNAI CNLNITLPAY SKSEKSEKKF KLGLFLIKSK
HASITEPQLQ SGQDPLKSKE ETLTIIADLL GFSWTELAKE LEFSENDIQS VRTDNPNSLQ
EQSHALLQRW VEREGKHATE DCLIKTLTKI NRMDIVHLIE
//
