ID H3DLP5_TETNG Unreviewed; 932 AA.
AC H3DLP5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=MOV10 {ECO:0000313|Ensembl:ENSTNIP00000021443.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000021443.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000021443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005601}.
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DR AlphaFoldDB; H3DLP5; -.
DR STRING; 99883.ENSTNIP00000021443; -.
DR Ensembl; ENSTNIT00000021678.1; ENSTNIP00000021443.1; ENSTNIG00000018277.1.
DR GeneTree; ENSGT00940000156024; -.
DR HOGENOM; CLU_001666_6_1_1; -.
DR InParanoid; H3DLP5; -.
DR OMA; NDWDQDQ; -.
DR TreeFam; TF323999; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR CDD; cd18038; DEXXQc_Helz-like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR049080; MOV-10-like_beta-barrel.
DR InterPro; IPR026122; MOV-10/SDE3_DEXXQ/H-box.
DR InterPro; IPR049079; Mov-10_helical.
DR InterPro; IPR049077; MOV-10_Ig-like.
DR InterPro; IPR049075; MOV-10_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF537; HELICASE MOV-10; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21634; MOV-10_beta-barrel; 1.
DR Pfam; PF21635; Mov-10_helical; 1.
DR Pfam; PF21633; MOV-10_Ig-like; 1.
DR Pfam; PF21632; MOV-10_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 8..68
FT /note="Helicase MOV-10 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21632"
FT DOMAIN 111..232
FT /note="Helicase MOV-10 Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21633"
FT DOMAIN 283..351
FT /note="Helicase MOV-10 helical"
FT /evidence="ECO:0000259|Pfam:PF21635"
FT DOMAIN 352..438
FT /note="Helicase MOV-10-like beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21634"
FT DOMAIN 489..572
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 600..675
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 684..908
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
SQ SEQUENCE 932 AA; 105553 MW; 0BEC85E36D88B08E CRC64;
MPLKDCHESG LDFIEFLGDR ISLTNKAELR EIYNNEFRGR AGIRDPNFSS VIYALRRFNK
VYCNRDHIFI NFFINDSAEM TLPSFYDTSY MPDLLSTSKS KFFTKKFYHI KELIANKGGI
EITSDPEAVE GKILFFVERL KDVFIVRFNV ANKGTSCVYF TYYTALHKIR CFTLDDDHRL
TRANPLLLCP GETYEVRVRY ILNHYGYFPA TMYFEFLITG STPFCIIREM EAAARTPLAD
ILGPVSPYKP LRVQARSHVS TVEVEGVPPE KFKAHDWLVV VVLDEYKPGE YLKQLTKQSL
EDSEHLSPVL RQKLLSAGAL LKSALELKTY SSRFHLLLHL EEIQMEVDIR KYDLRNQTMT
LDQSNKKLIS LSVPGVAENR PSVLRGDCIK VTMSDDKNNP TVVYKGYVHK VELDGVKLGF
SQSLLQRFLP NMKFDVEFTV NRLTLKLQHR AVDLAAKHQL GELLFPSGAA ADTPPMPNLR
MFNLKLEKNP EQSAAVQHII AGSSKPAPYL VFGPPGTGKT ITIVEAMHQV NKCNPTAHIL
ACAPLNSACD LLCERLLDHI DSHQVYRMYA SSRDPRSIPS PLLKCCNWDK TKECFVFPSR
ETLMKYKVVV TTLCTAGRLV TGGIPVGHFT HIFVDEAGQA VEPECIIAVA GLFNPKEGQL
VLAGDPKQLG PILRSPLALQ YGLGVSLLER LMKDNTLYQQ NPDTGHFDNR YVTKLLRNYR
SHAAILKVPN ELFYSNELQV FADQWERAVY CNWEGLPKKG FPLIFHGVMG KDEREANSPS
FFNVTEIDAL VKYLTLLFET QGKKGIPKLL AKDIGIIAPY RKQKVEKIRR ALKSAPVTKR
CGDLTDLKVG PVEEFQGQER KIIMISTVRS SDYVKLDQDF SIGFLSNEKR FNVAVTRARS
LLIIVGNHII LNKDPTWAKF IKYCVTQKGC AG
//
