ID H3DLU2_TETNG Unreviewed; 572 AA.
AC H3DLU2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Sorting nexin 27b {ECO:0000313|Ensembl:ENSTNIP00000021490.1};
GN Name=SNX27 {ECO:0000313|Ensembl:ENSTNIP00000021490.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000021490.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000021490.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3DLU2; -.
DR STRING; 99883.ENSTNIP00000021490; -.
DR Ensembl; ENSTNIT00000021725.1; ENSTNIP00000021490.1; ENSTNIG00000018322.1.
DR GeneTree; ENSGT00950000183212; -.
DR InParanoid; H3DLU2; -.
DR OMA; SGLHCTG; -.
DR TreeFam; TF318398; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR CDD; cd13338; FERM-like_C_SNX27; 1.
DR CDD; cd01777; FERM_F1_SNX27; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd06886; PX_SNX27; 1.
DR Gene3D; 1.20.80.60; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR037831; SNX17/27/31-like.
DR InterPro; IPR037827; SNX27_FERM-like_dom.
DR InterPro; IPR037833; SNX27_PX.
DR InterPro; IPR037835; SNX27_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12431; SORTING NEXIN 17 AND 27; 1.
DR PANTHER; PTHR12431:SF17; SORTING NEXIN 27B; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 51..144
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 169..277
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 281..370
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 64459 MW; 7B0B194BC2A6E19F CRC64;
MTDVDGQGTC SPPSPLPHPS TLTCSSSGNV TPGTGSSSCQ TATTVTSGPR LVRIVKSDSG
YGFNVRGQVS EGGQLRSING ELYAPLQHVS AVLPGGAADR AGISKGDRIL EVNGVNVEGA
THKQVVDLIR AGERELVLAV LSVPPQEADC LDPGDDVSAQ SCYDYSDKQA VPISVPSYKH
TELNQEKFVV YNVYMAGRQL CSKRYREFVI LHQNLKREFD NFAFPKLPGK WPFSLSEQQL
DARRRGLEEY LEKVCSVRVI GESDIMQEFL SDSDENYNGV SDVELRIALP DKTALTVRVR
KNATTDQVYQ AVVTKLGMDS VTSSYFALFE VINHTFVRKL APNEFPHKLY VQNYTSAIPG
TCLTMRKWLF TTEEEVLLND NQLAVSYFFH QAVDDVKKGS VKSEQKSYQL QKLVEQKKMA
AYLSLLRGCE GYNEIVFPHC SCDSRRKGHI IAAISIHHFK LHACTEEGTL ENQVIAFDWA
EMQRWDTDEE GMAFCFEYAR GEKKPRWVKI FTPYFNYMHE CFERVFCELK WRKEIEEEAT
DKDNKNCSKD EYFPAAEAQK GWRHLGQEII TS
//
