ID H3DMK4_TETNG Unreviewed; 565 AA.
AC H3DMK4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000021752.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000021752.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC {ECO:0000256|RuleBase:RU368069}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC ECO:0000256|RuleBase:RU368069}.
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DR AlphaFoldDB; H3DMK4; -.
DR STRING; 99883.ENSTNIP00000021752; -.
DR Ensembl; ENSTNIT00000021987.1; ENSTNIP00000021752.1; ENSTNIG00000018578.1.
DR GeneTree; ENSGT00390000015916; -.
DR HOGENOM; CLU_014030_1_0_1; -.
DR InParanoid; H3DMK4; -.
DR OMA; CNLAFRY; -.
DR TreeFam; TF105965; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR Pfam; PF03666; NPR3; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU368069};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Signal {ECO:0000256|RuleBase:RU368069}.
FT REGION 415..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 63531 MW; B7482A40078D5032 CRC64;
SGEKTSPISV ILVSSGSRGN RLLFRYPFQR VTECPASLAA KQRSRYALNT TGDVVEDQDG
DSRFSDIILA TILATKSDIC GKKFELKIDN VRFVGHPTLL QHPPVIQVSK TDPSPKREMP
TMILFNVVFA LRANADPSVI SCMHNLSRRL AIALQHEERR CQYLTREAKL MLAIQEEITT
ETDGNPQSPF RQILPKCKLA RDLKEAYDSL CTTGVVRLHI NNWLEVSFCL PHKIHRIGGS
YIPPEALEQS LKAIRPYHTL LLLESEKTLS QLPLDCSPAM VRLIKTCSAV KNLQQLAQDA
DLALLQIFQI AAHLVYWGKA IIIYPLCENN VYMLSPHANI CLYSSLAQQF SQQFPGHDLP
TMLAKFSLPV SLAEFRNPLE APAQEAQLIQ MVVWMLQRRL LIQLHTYVCL MVPPSEDEPS
ARDEDPPIRV GGRSLSTPSA LSFGSPTSSD DMTLTSPSMD NSSAELLPGG DSPLNKRITE
TLLASLSEHE RQVILSIPAA QNPEDLRMFA RLLHYFRGHH HLEEIMYNEN MRRSHLKTLF
DKFRSVLVVT NHEDPVISIF QSPMD
//