ID H3DMS5_TETNG Unreviewed; 1013 AA.
AC H3DMS5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Elastin microfibril interfacer 2a {ECO:0000313|Ensembl:ENSTNIP00000021823.1};
GN Name=EMILIN2 {ECO:0000313|Ensembl:ENSTNIP00000021823.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000021823.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000021823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR AlphaFoldDB; H3DMS5; -.
DR Ensembl; ENSTNIT00000022059.1; ENSTNIP00000021823.1; ENSTNIG00000018648.1.
DR GeneTree; ENSGT01030000234633; -.
DR HOGENOM; CLU_011705_0_0_1; -.
DR InParanoid; H3DMS5; -.
DR OMA; GPDCKDL; -.
DR TreeFam; TF331033; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF5; EMILIN-2; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF07546; EMI; 1.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..77
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 867..1012
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 86..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 525..565
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 86..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 112634 MW; 55320B62C32913DE CRC64;
HRNWCAYVVR RNVSCAVQDG VESFQEPIVA PCPVYQPDCQ QQVTYQNRFR PTYKIAFKTV
TELEWRCCPG YQGDCKDLKL LQHQQPASGI QPHQVSNPGH TTRHTQSTSP TGPERRETGH
HEIRHGGTDK VHLLEGEVNR LSQTVLSLQS ALKDLTEKLR ADLQEDTRKT LVSLLNDKRP
PDSSTAASTD DSPAVLDGQP TKGAALGDKA LEKIMVRLDD INSDLKNKDE ALEDLRGTMS
SHEGQIRVLM DASQAPAIAD FDVIQAYIDK SFEKMKKELD QNVEEHVTKL QSTCDDRIST
LQKTCEDSRD QGLVSLTKLV DTKEADLRKE MWEIRQEMAA ADIPIRTQRQ TDPAKPDEDH
GNHKDLWREI DRIAEAHRVL NIRIDNELAH LSEPPENNEI HLLIEDLEAR VNISEQNAET
HCFYIEQKLA RTITDEVVAL RHLMDKRLNN MKDQFTNMLV EMSNNSFPGM FSIDALQAEV
NSNRFHLRSL DDRVTLVAEL CSAGCLGSEN PVGSLPAGRG LETILKDMTQ NKNDYEVLLN
DVNANKHKLR QLEDLVQRLI SLQDNVLGLA GTVNGLSDSI HKSNQDMERI NSTCCPAGQS
GRGTPAWDSW ASLPNHDTRR QVEDLRRRLD SFSTQLSSDL SQCKQSTRGV SDEVSVVDDR
VSRLEKVCGR LDVVSTNIQE LKDGLERHVI GLRETVHKMN VTCVNQAADI VALRNSLQKL
DLHTEMYSLT LFPLWIFKPP VSSHTPETEE PESPAPLPDS TRARLHIPVI IPPLPSSPRQ
PYHPVQPAKP NTRTINVNPP QQPGDPAVIP EAPARPVMET GEAGPPGYIH RVTVRRGSED
SSSQPVQGFA GAPVCPYLIP VSAASASYAD PFSFSAGFTQ QSLSGDFGVI RFNRVLVNDG
GHYSPHTGIF TVPLDGRYLV SGVLTAQQGE RVRAVLSVSN RSVQRLQSAW RNEGSAPGKR
SCMGSAPFSL ILPLRKGDRV GVVKTEGQLA TTGSREILST FSAIFLYTPQ AKR
//
