ID H3DNV5_TETNG Unreviewed; 4930 AA.
AC H3DNV5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000022204.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000022204.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004326}.
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DR Ensembl; ENSTNIT00000022442.1; ENSTNIP00000022204.1; ENSTNIG00000019014.1.
DR GeneTree; ENSGT00940000155288; -.
DR HOGENOM; CLU_000040_2_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Ion channel {ECO:0000256|ARBA:ARBA00022673};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 4237..4257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4451..4471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4534..4556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4673..4694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4732..4752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4811..4834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..152
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 159..204
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 212..267
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 273..336
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 586..796
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1012..1208
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1341..1553
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1332..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3421..3443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4292..4420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3427..3443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4387..4420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4930 AA; 558860 MW; 7E1995376C3C108F CRC64;
MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL LYGHAILLRH NHSAMYLSCL
TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
LSYASGDLMV DASFMQTLWN MNPISSGCEL AEGFLTGGHV LRLFHGHMDE CLAIATPEEG
EEKRRMAHYE GGSVCSQARS LWRLEPLRIS WSGSHMKWGQ SFRIRHITTG RYLCLDEEKG
LLVVDPERAD TKHSAFCFRA SKEKVDVAQK RDVEGMGIPE IKYGESMCFV QHVSTGLWLT
YAALDAKAAR LGMMKRKVIL HQEGHMDDAL TVSRSQTEES QAARMIYSTV GLFRQFIKGL
DTLTGKNKSP GAVALPLEGV ILSLQDLIFY FRPPDEELEH EEKQTKLRSL RNRQNLFQEE
GMITIVLECI DRLNVYNTAA HFSEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFT
NLDWLVSKLD RLEASLSILE VLYCVLIESP EVLNIIQENH IKSIISLLDK HGRNHKVLDV
LRSLCVCNGV AVRSNQNLIT ENLLPGRDLL LQTNIVNYVT SVRPNIFLGT CEGSTQYKKW
YYEVMVDHVE SFVTQQATHL RVGWAMTDGY SPYPGGGEGW GGNGVGDDLY SYGFDGLHLW
SGTVPRQVAS PSAHTLAADD VVSCCLDLSV PSISFRINGH PVQGMFENFN VDSLFFPVIS
FSAGVKARFL LGGRHGDFKF MPPPGYAPCY EALLPRERMR IEPIKEYKHD FSGVRNLLGP
TLSLTHTSFT PCPVDTVQIV LPPHLERIRE KLAENIHELW AITRIEQGWT YGVFRDDNKK
LHPCLVDFQS LPEPERNYNL QMSGETLKTL LALGCHVGMG DEKAEENLKK IKLPKTYVMS
NGYKPAPLDL SHVRLTPNQN QLVEKLAENG HNVWARDRVR QGWTYSIVQD ILNKRNPRLV
PYVLLDEKTK KTNRDSVNNA VRTLIGYGYN IEPPDQESTG HGLENTRGDK VRIFRAEKSY
AITQGKWYFE FEAVTTGEMR VGWARPNVRS DTELGADELA YVFNGNKAQR WHIGNEPFGR
QWQSGDVVGC MIDLTEMNIM FTLNGEMLIS DSGSEMAFKD IEIGEGFIPV CTLGLSQVGR
INLGQNVSSL RYFAICGLQE GFEPFAINMK RDTTMWFSKS LPQFVPVPTD HNHIEVSRVD
GTVDSAPCLK LTHKTYGSQN ANTDMLFLRL SMPIQFHTTF KIPAGTTPLT RALNIPEDIA
VVEPDSEFEV LKKSASRKEQ EEDKKEPSVP KEVLAENEKD TVSEKGKKRG FFSKAKKAAM
TPLAPPPAPP TVPRLVEDVV PDDRDDPEII LSTTTYYYSV RIFAGQEPSG VWVGWVTPDY
HQYDQTFDLS KVRSVTVTVG DDKGNIYNSM KHSNCYMVWG GDLVSNHQTR FSQEDMVIGC
LVDLATGLMT FTANGKEINT FYQVEPNTKL FPAVFIQPLS QNLVQLELGK LKNIMPISAA
MFRSERNNPV PQCPPRLDVQ MLTPVIWSRM PNRFLNPEVG RVSERLGWVV ECTEPLIMMA
LHIPEENRCI DILELSERQD LMKFHYHTLM LYCAVCALGN NRVAHALCSH VDESQLFYAT
ENTYLPGPLR SGYYDLLISI HLESAKRARL GTNREFIVPM TEETLSIKLY PDAVKAHSLP
GVGLTTCLRP KLHFSSINFV GTDPDLYTLS PVFPLQELKT RAISMLTEAV LDGSQAMRDP
VGGSVEFHFV PILKLINTLL IMGIFNDEDT KHILKMIDPN VFSGKDEEED TEKPTEGGTA
EDDKAKEEES EEAAELLQMK LPESVKLQMC TLLQFFCDCE LRHRVEAIVA YSDKFVHDIQ
DNQRIRYNQL MRAFTMSAAE TARKTREFRS PPQDQVLLLT NFKHSLEDEE CPVPDDVRDT
LKEFHNDLLL HCGIHIEEEA VEEEVDTSLR GRLLSLVDKI KSLRGKKTEE KPEVEEETKP
STLQELISHT MIHWAQESFI QNPELVRLMF SLLHRQYDGL GELIRALPKA YAINAVSVQD
TMDLLECLGQ IRSLLIVQMG PEEERLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM
VNVLGGGDSK EIRFPQMVTN CCRFLCYFCR ISRQNQRSMF DHLSYLLQNS SIGLGMRGST
PLDVAAASCI DNNELALALQ EQDLEMVVMY LASCGLQMCP MLLSKGYPDI GWNPCGGERY
LDFLRFAVFV NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLAAME EAIKISEDPA
RDGPTVKKDR RFMFGGEEQQ EENRVHLGNA IMSFYSALID LLGRCAPEMH LIQAGKGEAL
RIRAILRSLV PIEDLVGVIS LPVQIPSYGK DGQIIEPKMS ASFVPDHKAS MVLFLDRVYG
IDNQDFLLHV LEVGFLPDMR ASASLDTVAF STTEMALALN RYLCSAVLPL LTKCAPLFAG
TDHRAIMIDS MLHTIYRLSR GRALTKAQRD VIEECLMSLC KYLRPSMLQH LLRRLVFDVP
ILNEYAKMPL KLLTNHYERC WKYYCLPNGW ANFGVTSEEE LHLSRKLFWG IFESLAHKKF
DAELFKIAMP CLCAIAGAIP PDYVDASYSS HTEKKASVDA EGNFDPKPVE TTNTIIPERL
DTFINKYAEH THDKWAFEKI QNNWTYGEVL DENAKTHPML RPYKTFSEKD KEIYRWPIKE
SIKAMLAWEW TLEKARDGEG EVEKKAATRK ISQTAQATYD PSHGYSPQPI DISGMALSRE
LQSMAEQLAE NYHNTWGRKK KLELQSKGGG THPLLVPYDT LTAKEKARDR EKAQDLLKFL
QLNGYAVTRG MKDMEQDISS IEKRFAYGFL QKLLKWMDIA QEFIAHLESE AVVSSGRVEK
SPHEQEIKFF AKILLPLVNQ YFKNHCLYFL STPAKVLGSG GHSSNKEKEM IASIFCKLAA
LVRHRVSLFG TDAGAVVNCL HILSRSLDAR TVMKSGPEIV KAGLRQFFES AADDIEKMVE
NLKLGKVSSR NQVKGVSQNI NYTTIALLPV LTSLFDHIAQ HQFGDDVILD DLQISCYRIM
CSIYSLGTVK TPHAEKQRPA LGECLAHLAA AMPVAFLEPV LNEFNMFSVY TTKTPRERTI
LGLPNQVEEL CPDIPELEVL MKDIHDLAES GARYTEMPHV IEITLPMLCN YLPRWWERGL
ENFPEQEGQL CTSVTSEQLN QLLGSIMKIV VNNLGIDEAS WMKRLAVFAQ PIVSRAKPEM
LKSHFIPTME KLKKRSGKVV AEEDHLRMEG KTEVDSENGT IRDEFAVLCR DLYALYPLLI
RYVDNNRARW LTNPDPDAEE LFRMVGEVFI FWSKSHNFKR EEQNFVVMNE INNMSFLTAD
SKSKMSKSGG SEQERTKKKR RGDRYSVQTS LIVAALKKLL PIGLNMCSPA DQELINLAKI
RYSLKDTDEE VREFLHNNLH LQGKVEDPAM RWQMSLYKEM AGKAEDAEDP EKVVKRVQEV
SAVLYHIEVT EHPFKSKKMV WHKLLSKQRR RAVVACFRMT PLYNIITHRA TNMFLDAYKR
NWLETEGYSF QDKMIDDLSV SSDHSNEMSS RKERKPDPLH QLILHLSRTA LTEKTKLDVD
HLYKNYAEIM AKACYITFST GASSFERFQR SSSSSASQEK EMEIQRLLYQ QSRLHNRGAA
EMVLQMISAC KGEPGAMVSS TLKLGISILN GGNSDVQQKM LDYLKDKKDV GFFLSVQSLM
QTCSVLDLNA FERQNKAEGL GMVSEEGTSL SSTDSHEIPG LTVSLFGFLS PSFALHAAVQ
QNRLMHPDPG QRTGVRICVI FMPCHVFHLS KTLSHLHFLT LPKSLTATGN SFLLCWCRFF
RNACSNSTNV IVHAHLFVTL TELYFCFAVF FLTFLQDSSQ IGLLKELLDL QKDMVVMLLS
LLEGNVVNGT IAKQMVDMLV ESSSNVEMIL KFFDMFLKLK DIVASDAFRD YVTDPRGLIS
KKDFSKAMDS QKQYTPGEIQ FLLSCSEADE NEMINFEEFA DRFQEPAKDI GFNIAVLLTN
LSEHVPHDTR LQNFLEQAES VLNYFRPFLG RIEIMGASRK IERIYFEISE ANRNQWEMPQ
VRESKRQFIF DVVNEGGESE KMEMFVNFCE DTIFEMNIAA SISEPEGDDG NGEEQAPEST
SAFADFIKSV VNFFNMFTFR NLRRRYRRFR KMTVKEMVIG LVTFVYTVLM GILMFVYSIC
KGFFTLIWKV LFGGGLVESA KKMTVTDILA SMPDPTQDEV HGELPPEPGS REVQDTEGGA
DLLDPVGGEE EEEDSEEREG GRLPGFNTPG GLGDFGETTP EEPPTPEGTP LLKRKLLSVS
FMSSTENGEK AEKEPEPEPE PKEEEPAEKE EAAVKTKAKK SKKPVEEGFE LWNELEIQRV
KFMNYLSRNF YNLRFLALFI AFAVNFILLF YKVSDSPPGE EDFEGSGLFE GSGLFEGSGA
PEDGSGFDDG GEDDEEEGPL YYFLEESTGY MEPAMAFLSI VHTIISFLCI IGYNCLKVPL
VIFKREKELA RKLEFDGLYV TEQPEDDDIK GQWDRLVLNT PTFPNNYWDK FVKRKVLDKY
GDIYGRERIA ELLGMDLASL DVSAMTHEKK PEPDTSMFSW ITSIDVKYQI WKFGVVFTDN
TFLYLVWYLL MSILGHYNNF FFAAHLLDIA MGVKTLRTIL SSVTHNGKQL MMTVGLLAVV
VYLYTVVAFN FFRKFYNKSE DEDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD
EYELYRVVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGSDY
FDTTPHGFET HTLEEHNLAN YMFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC
FRKQYEDQLG
//
