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Database: UniProt
Entry: H3DPU4_TETNG
LinkDB: H3DPU4_TETNG
Original site: H3DPU4_TETNG 
ID   H3DPU4_TETNG            Unreviewed;       217 AA.
AC   H3DPU4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-OCT-2019, entry version 40.
DE   SubName: Full=Cyclin-dependent kinase inhibitor 3 {ECO:0000313|Ensembl:ENSTNIP00000022543};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000022543, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000022543}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000022543}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   Ensembl; ENSTNIT00000022782; ENSTNIP00000022543; ENSTNIG00000019340.
DR   eggNOG; KOG1720; Eukaryota.
DR   eggNOG; COG2453; LUCA.
DR   GeneTree; ENSGT00390000004717; -.
DR   InParanoid; H3DPU4; -.
DR   OMA; ALPGCKY; -.
DR   TreeFam; TF101040; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR008425; CDK_inhib_3.
DR   InterPro; IPR022778; CDKN3.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF05706; CDKN3; 1.
DR   PIRSF; PIRSF037322; CDKN3; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01031440};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT   DOMAIN      125    190       TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE:
FT                                PS50056}.
FT   REGION        1     24       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      121    141       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS      1     15       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   ACT_SITE    145    145       Phosphocysteine intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR037322-1}.
SQ   SEQUENCE   217 AA;  24920 MW;  D2F7F5178349C937 CRC64;
     SSEASVFCSA MRTSEFDSSS EEEVEEEQLT PLHVSWVPLS VVECSQFLGI CGLPGCRYKD
     IRRSLDRDME ELQNQGVQEV FVFCTRAELH WYRVPSLLDA YRQRGFSVHH MPFPDGDVPE
     LEQCSQILEE LQASLENNRR TLIHCYGGLG RSGLIAACLL RLSETLTENQ VIEILREHRG
     GGAIQTVKQY NFLHQFREKY SAYLERREAS LERSVSR
//
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