ID H3DR59_TETNG Unreviewed; 1792 AA.
AC H3DR59;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Kinesin family member 1B {ECO:0000313|Ensembl:ENSTNIP00000023008.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000023008.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000023008.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSTNIT00000023250.1; ENSTNIP00000023008.1; ENSTNIG00000015171.1.
DR GeneTree; ENSGT00940000157445; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..357
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1670..1768
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1518..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1590..1631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 637..679
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1792 AA; 201828 MW; 46CB0922164D70E7 CRC64;
MSGASVKVAV RVRPFNSREM NMDAKCIIHM QGNSTTISNP KAPKEPAKNF SFDYSYWSHT
TLEDPNFASQ NRVYNDIGKE MLEHAFEGYN VCIFAYGQTG AGKSYTMMGK QEEGQEGIIP
MLCEDLFEKI NEENNKEELS YSVEVSYMEI YCERVRDLLN PKNKGNLRVR EHPLMGPYVE
DLSKLAVTSY TDIADLMDAG NKARTVAATN MNETSSRSHA VFTIVFTQKK HDSETDLSTE
KVSKISLVDL AGSERADSTG AKGTRLKEGT NDRRQACCNV CHSVFSFLCH ADNCTNKSKK
KKKTDFIPYR DSVLTWLLRE NLGGNSRTAM VAALSPADVN YDETLSTLRY ADRAKNIKCN
AVINEDPNNK LVRDLKDEVS RLKELLRAQG LGDILDTPLG SLTASPSYCS YEPALTIRAA
VSIATTVASV SSSDVKHLHR YRESEKIIAE LNETWEEKLR KTEAIRMESS FFLPPQGGLR
EDGGTLGVFS PKKTPHLVNL NEDPLMSECL LYYIKDGITR VGQADAERRQ DIVLSGAHIK
EEHCIFRSER NANGDVVVLL VPCEASETYV NGKRVEDAIQ LRSGNRIIMG NHVFRFNHPE
QARAEREKTP SAETPMEPVD WTFAQRELLE KQGIDMKQEM EKRLTEMEIL YKKEKEEADQ
LLEQQRLVYE SKLQELQKQV ETISLVAETP DEEELDEEEE EEVPWTQHEF ELAQWAFRKW
RYHQFTSLRD QLWGNAVYLK EANAISVELK KKVQFQFVLL TDTLYSPLPP ELGSPEPEKE
RDPRPFPRTV VAVEVQDLKN GATHYWSLDK LKQRLEKMRE MYDRAGEMTS TNQEEGEGTL
TGNDPFYDRF HWFKLVGSSP IFHGCVNEHL ADRTPSPTFS TTDSEITEMA DERQSEMSDL
IDDEAFVDDT SSDAGTEEGS DIFSDGQDPF YDRSPWFILV GRAFVYLSNL LYSVPLVHRV
AIVTEKGEVR GFLRVGVQAI AADEEAPDYG SGVRQSGTAK ISFDDEYFKK NDFPSTVMTR
SGMSLEELRI VEGQGQSSEV ITPSEELNRI NDIDLKLGNV ADTKLSRDGL AGQLEVGSIF
TFRVTVLQAS GIQPEYADIF CQFNFLHRHD EAFSTEPLKN TGKGTPLGFY HVQNISVEVT
ESFVEYIKSK PIVFEVFGHY QQHPLHLHGQ ELISPPTQSR KYYPIPMPLS KPVPATKLNT
ITKSNLGQCV SKYDLLVWFE ISELEPTGEY IPAIVDHSGG LPCHGTYLLH QGIQRRITVT
LIHEKGSELH WKDVRELVVG RIRNKAEVDD SASDGVLSLN IISAKNIKSS HNSNRTFYRF
EAVWDSSLHN SLLLNRVTPY GEKIYMTLSA YLELDHCIQP AIITKDICMV FYSRDAKISP
PRSLRNLFVS GYSKTPDCNR VTGIYELSLC KMSDTGSPAG MQRRRRKVLD TSVAYVRGEE
NLAGWRPRGD SLIAEHQWEL EKMEQLHEVE KTRHLLLLRE KLGDANPAPS TKSLSELLSP
SMSSGTLSTS TSISSQISST TFESAITPSE SSGYDSTDIE SLVDREKALA TKCLRLLTHT
FNSEYNQVVN SISDCKLSDI SALGRDPSVT SFSSATLTPS STCPSLADSR CGSIDQKTPE
NSSRASSPSC SDYENFPMVP SLETSYLARA GKNEFLNLVP DIEEMRPGSV VSKKGFLSFM
EPRSNSWVKH FVVVRRPYVF IYNSDKDPVE RGVLNLSTAQ VEYSEDQQAM LKTPNTFAVC
TKHRGILLQA LNEKDMNDWL YAFNPLLAGT IRPLNFSSPI ICKEMSISVS FV
//
