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Database: UniProt
Entry: H3ESH5_PRIPA
LinkDB: H3ESH5_PRIPA
Original site: H3ESH5_PRIPA 
ID   H3ESH5_PRIPA            Unreviewed;       272 AA.
AC   H3ESH5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   28-MAR-2018, entry version 40.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:PPA12742};
GN   Name=WBGene00102296 {ECO:0000313|EnsemblMetazoa:PPA12742};
OS   Pristionchus pacificus (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Diplogasterida;
OC   Neodiplogasteridae; Pristionchus.
OX   NCBI_TaxID=54126 {ECO:0000313|EnsemblMetazoa:PPA12742, ECO:0000313|Proteomes:UP000005239};
RN   [1] {ECO:0000313|EnsemblMetazoa:PPA12742, ECO:0000313|Proteomes:UP000005239}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA12742,
RC   ECO:0000313|Proteomes:UP000005239};
RX   PubMed=18806794; DOI=10.1038/ng.227;
RA   Dieterich C., Clifton S.W., Schuster L.N., Chinwalla A.,
RA   Delehaunty K., Dinkelacker I., Fulton L., Fulton R., Godfrey J.,
RA   Minx P., Mitreva M., Roeseler W., Tian H., Witte H., Yang S.P.,
RA   Wilson R.K., Sommer R.J.;
RT   "The Pristionchus pacificus genome provides a unique perspective on
RT   nematode lifestyle and parasitism.";
RL   Nat. Genet. 40:1193-1198(2008).
RN   [2] {ECO:0000313|EnsemblMetazoa:PPA12742}
RP   IDENTIFICATION.
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA12742};
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Structure-specific nuclease with 5'-flap endonuclease
CC       and 5'-3' exonuclease activities involved in DNA replication and
CC       repair. During DNA replication, cleaves the 5'-overhanging flap
CC       structure that is generated by displacement synthesis when DNA
CC       polymerase encounters the 5'-end of a downstream Okazaki fragment.
CC       It enters the flap from the 5'-end and then tracks to cleave the
CC       flap base, leaving a nick for ligation. Also involved in the long
CC       patch base excision repair (LP-BER) pathway, by cleaving within
CC       the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a
CC       genome stabilization factor that prevents flaps from equilibrating
CC       into structurs that lead to duplications and deletions. Also
CC       possesses 5'-3' exonuclease activity on nicked or gapped double-
CC       stranded DNA, and exhibits RNase H activity. Also involved in
CC       replication and repair of rDNA and in repairing mitochondrial DNA.
CC       {ECO:0000256|SAAS:SAAS00725765}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion
CC       {ECO:0000256|SAAS:SAAS00725720}. Nucleus, nucleoplasm
CC       {ECO:0000256|SAAS:SAAS00725726}.
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DR   STRING; 54126.PPA12742; -.
DR   EnsemblMetazoa; PPA12742; PPA12742; PPA12742.
DR   eggNOG; KOG2519; Eukaryota.
DR   eggNOG; COG0258; LUCA.
DR   InParanoid; H3ESH5; -.
DR   OMA; YQPPENW; -.
DR   OrthoDB; EOG091G0C0E; -.
DR   Proteomes; UP000005239; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0048256; F:flap endonuclease activity; IEA:EnsemblMetazoa.
DR   GO; GO:0006309; P:apoptotic DNA fragmentation; IEA:EnsemblMetazoa.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd09867; PIN_FEN1; 1.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR023426; Flap_endonuc.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR019974; XPG_CS.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   PANTHER; PTHR11081; PTHR11081; 2.
DR   Pfam; PF00867; XPG_I; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00485; XPGN; 1.
DR   SUPFAM; SSF47807; SSF47807; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
DR   PROSITE; PS00841; XPG_1; 1.
DR   PROSITE; PS00842; XPG_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005239};
KW   Mitochondrion {ECO:0000256|SAAS:SAAS00725731};
KW   Nucleus {ECO:0000256|SAAS:SAAS00419039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005239}.
FT   DOMAIN        1     85       XPGN. {ECO:0000259|SMART:SM00485}.
FT   COILED       75    102       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   272 AA;  30777 MW;  50BCF02A13BB60F2 CRC64;
     MKSFFGRKVA VDASMCLYQF LVAVRSDGSL LQTADGETTS HLMGIFYRTI RMIDNGIKPV
     YVFDGKPPDM KSGELEKRAQ RREDTEKQLK EAEEEGNAED IQKFERRLVK VTKSHNDEVK
     QLLRLMGIPV VEAPCEAEAQ CAELVSSGKK YPPPADWPFK RARELFITPD VKKGSEVELV
     WKEPDVEGVV AFMCGEKAFE YVNWCRETRI RNSLAKMSKG RQAASQGRID SFFTTQKTVK
     VETLSTAAAR KRKADEKDGK KRGSAKKIKI ND
//
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