ID   H3GBE4_PHYRM            Unreviewed;       710 AA.
AC   H3GBE4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) {ECO:0008006|Google:ProtNLM};
OS   Phytophthora ramorum (Sudden oak death agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra72607, ECO:0000313|Proteomes:UP000005238};
RN   [1] {ECO:0000313|Proteomes:UP000005238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX   PubMed=16946064; DOI=10.1126/science.1128796;
RA   Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA   Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA   Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA   Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA   Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA   McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA   Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA   Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA   Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA   Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT   "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT   of pathogenesis.";
RL   Science 313:1261-1266(2006).
RN   [2] {ECO:0000313|EnsemblProtists:Phyra72607}
RP   IDENTIFICATION.
RC   STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra72607};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; DS565998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3GBE4; -.
DR   STRING; 164328.H3GBE4; -.
DR   EnsemblProtists; Phyra72607; Phyra72607; Phyra72607.
DR   eggNOG; KOG4180; Eukaryota.
DR   HOGENOM; CLU_400895_0_0_1; -.
DR   InParanoid; H3GBE4; -.
DR   OMA; AWHYSAS; -.
DR   Proteomes; UP000005238; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0003951; F:NAD+ kinase activity; IBA:GO_Central.
DR   GO; GO:0019674; P:NAD metabolic process; IBA:GO_Central.
DR   CDD; cd07067; HP_PGM_like; 1.
DR   Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR   InterPro; IPR013078; His_Pase_superF_clade-1.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   PANTHER; PTHR13158; -; 1.
DR   PANTHER; PTHR13158:SF5; NAD KINASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF00300; His_Phos_1; 1.
DR   SMART; SM00855; PGAM; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT   REGION          324..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        41
FT                   /note="Tele-phosphohistidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT   ACT_SITE        131
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT   BINDING         40..47
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT   BINDING         108
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ   SEQUENCE   710 AA;  80670 MW;  1B65EE239A40CC1F CRC64;
     MLRTARCRLP VRAASTVRHS SSTSTSSIRL PRLSDLVLIR HGESEGNVAR QRSLAGDHSL
     FAGEFKHRHS SNWRLTDRGR RQAAAAGDWL KRNNLAHFDR YLVSEYLRAM ETAGRMGLPD
     ARWYAEMLIR ERDWGAMDLM SEQERFVKMQ DELKRRELNR FYYAPPGGES LAAVAQRADR
     LLGILNHECH DKRAIVVAHG EVIWAMRTRL ERMSQDTFIE LQESGRMVDQ IHNGHILHYT
     RKDPQTGKMA PFFTHVRSVC PWNEKLSPKG WMKIDRPVYD NELLLATAER VPRMIISEEY
     LEKTYNGAKT LSDADMNSDV LAHSTSLSQA SSGTEGTTTT AGTSSKKEER QTPLLIPGKP
     MLNLKKVVVV KKTSRFQHEA ELYGNTDEAL RKQMSMRGFV HDRLKASHEH HVEAVDEITS
     SFKERDIEVK VVSANQLTHE AVEGTDMIFS AGGDGTFLKT ASFVNTPTPV AGLNTDPKRS
     EGNLCCYKVD NVTHRFSTAL DRLLEGDFKW RLRQRIRVGM VNQDGYWYEL PRYALNEVFI
     AESDASRPSH YNIGIDQHQR ESHRSSGILM CTGTGSSAWY SSACQVYREQ VANVLSAMNH
     THTNETVTEL TESINKQNVF PEDSRDMGYI VREPIINATF GDIRFRRGKA RRVSMRSLGW
     DMKVNIDGIY SVPLDYGVQA VMKIVDEPKY VLRTVDFSPL PGSAPKKNIF
//