ID H3GCM0_PHYRM Unreviewed; 802 AA.
AC H3GCM0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra73227, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra73227}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra73227};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ANKZF1/VMS1 family.
CC {ECO:0000256|ARBA:ARBA00009262}.
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DR EMBL; DS565999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GCM0; -.
DR STRING; 164328.H3GCM0; -.
DR EnsemblProtists; Phyra73227; Phyra73227; Phyra73227.
DR VEuPathDB; FungiDB:PSURA_73227; -.
DR eggNOG; KOG2505; Eukaryota.
DR HOGENOM; CLU_014293_0_1_1; -.
DR InParanoid; H3GCM0; -.
DR OMA; GPHIFMC; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047139; ANKZ1/VMS1.
DR InterPro; IPR010441; CH_2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041540; VATC.
DR InterPro; IPR041175; VLRF1/Vms1.
DR PANTHER; PTHR16036; ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR16036:SF2; ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF18826; bVLRF1; 1.
DR Pfam; PF06294; CH_2; 1.
DR Pfam; PF18716; VATC; 1.
DR SMART; SM00248; ANK; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 422..454
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 608..713
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 120..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 746..780
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 362..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 90407 MW; ED0ACA17E5143D35 CRC64;
MTSKKPTQTY GRIALSDLTR DQTSQWSVRA VAGISRQFER PQPQNDASTD SATALRLQTA
TLDKLMSVGL RCGACDVTAF ASLDEQYAHF KSAAHCVNLK RRARGLPCLS EEDALQYLET
HSQEKKGRTN KDGGYSSSSS SSSWEEEEEQ EKLPTTTEPV VEFSDGKSVF KVFKNILPDA
EEESFNPYTS LEQICASKFR WAVLLLRSGR FAGAVFEKDK ALCHKTFQRY TTRRKQGGAQ
SASDASGKAK SAGATLRRYN EAALKQDVAA LLVEWKGVLK DTELIFLSSG KTERATFFPE
KNTVLQSDDK RLKRIPFATF RPTFEEVCRV RSDLSSVRFS PLEAAASSPV ESTKKAKKKK
KSGEPAPGPE VKEDTPKEDE VKEGEEVPQI IQLVNSGDLK SVKEFLSNAD EKDVEVNEVD
AKFMTALHHA AAKNEVPIVE YLLEQGANPA LLDLHNRPPY FLCDTKEARN AFRRYMAEHP
GAWDYAIAQI PEGLTSEMEQ RKKEKEAEKR RRARERKKQQ KREAVEQKRE EEARQEELER
KIAAGLACDF CGKYAGKSPF TRLEFKYCST DCVNGHKRKL MSEAALRRLV LWDRRKAGNT
MMDLPLDDET LQRVYAWIDE IPLSRPKKSI ARDFSDGILT AEVVAFYFPK LVQMHNYSAA
NSIKQKQYNW NTLNRKVFKK LHISLSKEDI DDLVQCQPGA IEHLLVKLQL KDPIDVGGFM
ESPAAPVHPM DSIGKSYTPG TEASAKSELR QELAEKDSVI AELRETAQIL EMKVQKLEQL
VRLKDGKIQT LVAKLRSQKP QA
//
