ID H3GEV2_PHYRM Unreviewed; 851 AA.
AC H3GEV2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra74207, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra74207}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra74207};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; DS566003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GEV2; -.
DR EnsemblProtists; Phyra74207; Phyra74207; Phyra74207.
DR VEuPathDB; FungiDB:PSURA_74207; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_009133_0_0_1; -.
DR InParanoid; H3GEV2; -.
DR OMA; GKGFFAW; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 2.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..176
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 195..307
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 358..412
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 425..704
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 781..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 237..304
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 787..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 95650 MW; 9E2EE259BC4E84A2 CRC64;
MADAASAAES VIDDAATEDL TPSSTILDGM RVYFVIGAIG WLAFELGRVK LQRAYYCREG
KAETTNRIVT RCHDSKVFGW LKLLFVTSDD ELMDQCGMDT LFFFRFLRLC EKVTAVGVLC
SAATFPIYYY AKRDTLDALY RMTLSHLDTD EMWRFWFTVV TMYLVSLTTC YLLWQEYQEY
IRRRHEFMSR KHSQQYTVVL NGLPPNLCTQ QTLRNYLELL FPKSVLHVYV ALECRDLEKL
VAERVKVRNK LEHVLAQSAL TGERVMTRNK LLGGEKVDAA ELYQDQLKEL NMAVEKELRS
IMRNQAAVAR QLVESSGDDE TYGFNQNNMD SARSINFAYK EEELDSGAIE SRYIKSLKRQ
DKKAVGIMRG AGFVTFRSLK VAQSCTQILQ SANPTQMHVE PAAYSEDVVW ANIGLSKNIK
DTWFLISMGL STAIILLWTV PTGIVVSFAK VSSLEQNWAW LAQVIRDYPW VKSVLEQVSP
LMLSVMTALA PIIFGILSKR EGHAFDSQVN ASLLNKLVIY QIYVTFLLPI IGGTVIDAVM
GSGNTDLTDV SAVLTIISDA VAVQSAFFIT YLLVRTGLNL TLILLRVTPI VKAAIYQVFA
PKLTPRERAS AWFGLNSLAH PGDFSASDLV SEYFLVLMLV LVFCGIAPIL SYFALLYLML
SDFVYRWAVL CVHDPSTQTS GTYFPSLYRF IVGALLFAQI ILASVLATKQ VALPATFAII
LPFITVAFHL FVSTRYPKIA LNLPLDQAVI VDSRRSRQME DLERVLENVY MQPAVLERGP
LEPDYQGLTS DPNSENQLAS PPPVENNVQG SDSAPYQRME SRNRPGRHDS VGGLVCAMTI
SARLGPWYRM G
//
