ID H3GFE1_PHYRM Unreviewed; 609 AA.
AC H3GFE1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=6-phosphogluconate dehydrogenase NADP-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra74415, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra74415}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra74415};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; DS566005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GFE1; -.
DR STRING; 164328.H3GFE1; -.
DR EnsemblProtists; Phyra74415; Phyra74415; Phyra74415.
DR VEuPathDB; FungiDB:PSURA_74415; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_030076_0_0_1; -.
DR InParanoid; H3GFE1; -.
DR OMA; MGPRIVK; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT DOMAIN 332..491
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 494..597
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 66544 MW; 18E3AC74C8BABB20 CRC64;
MDSAGKERRR GSACPSGSAG FSTIQKDVNG SLDGAASDAT ANAMASVNEA MTLQQRQAAS
TFTSLLGKRE GDAELHENEQ EDEEEESTRL LPMVEEEQAM VQCEGMEQCF DSWDDFHHAM
DEYCEATHQP MRLRTSDSAK AVNSRAAKRN SLKEPIDESV GFVKKLYLCT HGVKTKPRGK
GKRPRQHYRY MGCPAMIRAC ISERKANDPE DQGKSKYVVR VVAQINRHNH RLSEHLFKSY
AESRVVIDEE LVVPNPQSRP KEEQIVTSSA TTPITAEEHV TTTAHSDLED PSLKTNPLFQ
AQTLDLMAAS RVKIRKSAWT TGLLTTSHVY SVGWIGVGIM GASMCGHLMN HGYEVTVYNR
TLSKCDGLRE KGARVAGSPA EVAQNSDVVF IMVGYPSDVK AVVFAPDSGL LQRMKPGGII
VDMTTSEPAL AKKIHEAAKL KGVSTLDAPV SGGDVGARDA TLSIMVGGDM DIVYATMPFF
SIMGKTVRHM GPAGAGQHTK MMNQILIATN MIGVVEGLLY AKKSGLDMDE AIRAMSAGAA
GSWSVSNMGP RIVKRDFDPG FFVEHFLKDM GIALKEAERM NLSLPGLSLA HQLYIAVKVF
IRRKPTTWK
//
