ID H3GGU0_PHYRM Unreviewed; 593 AA.
AC H3GGU0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblProtists:Phyra75075};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra75075, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra75075}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra75075};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D
CC function by capturing and stabilizing tubulin in a quasi-native
CC conformation. Cofactor E binds to the cofactor D-tubulin complex;
CC interaction with cofactor C then causes the release of tubulin
CC polypeptides that are committed to the native state.
CC {ECO:0000256|ARBA:ARBA00026055}.
CC -!- SIMILARITY: Belongs to the TBCC family.
CC {ECO:0000256|ARBA:ARBA00008848}.
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DR EMBL; DS566008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GGU0; -.
DR STRING; 164328.H3GGU0; -.
DR EnsemblProtists; Phyra75075; Phyra75075; Phyra75075.
DR VEuPathDB; FungiDB:PSURA_75075; -.
DR eggNOG; KOG2512; Eukaryota.
DR eggNOG; KOG3206; Eukaryota.
DR HOGENOM; CLU_032612_3_0_1; -.
DR InParanoid; H3GGU0; -.
DR OMA; CEFFVAC; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0007021; P:tubulin complex assembly; IBA:GO_Central.
DR Gene3D; 2.160.20.70; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 1.20.58.1250; Tubulin Binding Cofactor C, N-terminal domain; 1.
DR InterPro; IPR017901; C-CAP_CF_C-like.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR027684; TBCC.
DR InterPro; IPR031925; TBCC_N.
DR InterPro; IPR038397; TBCC_N_sf.
DR InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR PANTHER; PTHR15139; TUBULIN FOLDING COFACTOR C; 1.
DR PANTHER; PTHR15139:SF0; TUBULIN-SPECIFIC CHAPERONE C; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF07986; TBCC; 1.
DR Pfam; PF16752; TBCC_N; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT DOMAIN 190..223
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT DOMAIN 389..561
FT /note="C-CAP/cofactor C-like"
FT /evidence="ECO:0000259|PROSITE:PS51329"
FT REGION 378..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 65138 MW; C30C28458770E46A CRC64;
MFVLAVLHLT AGDDHAGLRH PEEHGVRGLG IRAARGNQPE VGSPAGEDIP AEEGIPAEVG
SLVGEGNLAV GEGSPAAADI LAAAAGNLAA EAGNLAAAGT PAAAARCDWL YPSHIWLAVI
RRNILLSTNH TPTKTELYEP GRDAKMEPLT IGTRCELLSS GPSGSLRASI KRYGEIVYIG
AIEGLPGDGW LGVRLDKPLG KGDGSFQGTR YFECKPLHGA IVRPERVNIK GEFPVLATHE
ESLAHALEER RREKQGARSS TGWRLQRELT TDELATAFWE TFTKQEEHVR KQVGLFCEQK
KQPLPCEPAK EVKLDALVLE VNTMRDAAAT AASLYLSPYD TRHTQLILAK LLELIDSTRA
TFAPRKKFTF RAHAARKAKS KTAETQDEPE QDTSFRSADV VSNQQTAQKL MEFDELVHAN
KQNEVIIIDS SSFSGSDDSK RRDLNFSRLT NCVVLVCVET SAIRGDALKN CVFYTGAIFG
SLWLESCNGC EFFVACRQLR VHLSTATTFH LRISSHPIIE DCQQMLFGPY RLQFDGLTAQ
LERLGVQKDS GLWAKVNDFK WHKAQQSPNW SIRDPKQPLP GIPVELENLV SYE
//
