ID H3GLW2_PHYRM Unreviewed; 689 AA.
AC H3GLW2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra77424, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra77424}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra77424};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; DS566021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GLW2; -.
DR STRING; 164328.H3GLW2; -.
DR EnsemblProtists; Phyra77424; Phyra77424; Phyra77424.
DR VEuPathDB; FungiDB:PSURA_77424; -.
DR eggNOG; KOG2165; Eukaryota.
DR HOGENOM; CLU_007149_4_1_1; -.
DR InParanoid; H3GLW2; -.
DR OMA; FMYETFA; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF08672; ANAPC2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 364..573
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 689 AA; 78608 MW; 71BC27FC047F9BC7 CRC64;
MSGGLRVDRE LLWRKLFAFD HQPAEDLSAN AQDLSDRLCG VIQRAVHQGR QEPLRQMLLQ
RLGYWLRSDV APPFWSFFDA LPAEIQRSNK RSRRQLALLC AQQLTLALQF AEDAFAHCVQ
LASLFDEQQL KSGGMLQELR TSFRCIVLED AERFEELLVI FFSMSFHRFR GLEQAQAFDA
RPIRQTLLQL QWLHVAEPAL LRVLHSQVKK VVRATCGDAF DELFLAEVEH WACSELLPWL
QETMQTNDHE SVQKWRDTLS QHVLQEFGTL RIAQLFEIIK EFPDSIPALE DLRQCLERTQ
QHGQLVREFR AALQSRLLQP GANTAAILDI YVSTIKYLRK RKDTVRCIVQ SLTDEQNGDL
FEELRRDNMR IIQHDDDSDD DENLEFDTDR DVQTLELLKL RFGEDSLQQC EIMVRDIEDS
KRLNLNVRST MENPAAKAAA AAEARARRGT KSPLDCVGAP STRVDATIIS QQFWPPLQGE
DFTLHPKVSK DIDAFKDSYH VLRNPRSLDW NPSLGSVQLS IDLEGEEREF TVSPLQATII
LYFDEKDRWG VEELAGKLEI SDDLLLKHIS LWVNHGLVSF ASGRKELVAS SSFLNTRCDD
NSMVEELETA VSSDAQAEED LKVLETYIVG MLSNFGSLTI HRIHNMLSTF ARSGAQPYTK
TISGLSVVLG KLVDKGKLEL VGGQYQLAR
//
