ID H3GNL4_PHYRM Unreviewed; 701 AA.
AC H3GNL4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra78204, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra78204}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra78204};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS566027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GNL4; -.
DR STRING; 164328.H3GNL4; -.
DR EnsemblProtists; Phyra78204; Phyra78204; Phyra78204.
DR VEuPathDB; FungiDB:PSURA_78204; -.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_393566_0_0_1; -.
DR InParanoid; H3GNL4; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..701
FT /note="CNNM transmembrane domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012045279"
FT TRANSMEM 48..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..230
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 249..311
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 701 AA; 77504 MW; FBCDBEDE5CAC01BC CRC64;
MVSSTTLLLF RAASASLVVR RLMDGDHEEA SAAADSDTGS ARSDTFKAIH YAGILGLIVM
SAISSGLTLG LMSLDKVSLD VVVRAGDRAE ATTDEVLKAK AAKRILPVRA DSNLLLTTLV
LTTVAVNSLL SILMADLTSG LVGFFASTII IVLFGEIVPQ SLCARHALII GSAFVPVVRV
LLFVLYLFAK PVSYVLDRTV GEDVGTMFTK RELQKLVEIH VRQKVVHPEE GYIVRGAMSY
KHKVVSDIMI PADKLFSLPI SFPTMKFYTL KMIYNSGFSR IPVWNKDPND VVGIVFTKDL
IYVDPNEDVP LLAFARVFAV SAHRIWLDAQ LGEVLSVFKM GSTHMALVYD VNNAGPGDPF
YELKGLVTLE DIVEDILQSK ITDETDSPEA RKERQNCTDQ IGYSDEAHAA AAFADKIWIV
GGVSASYYTK RLEYTTSRSD VIFSLDGVEW TEVLEEAPFR RRYGHSLTTF TDSSDNVERL
TLLGGFSPEA ATDIWVTTDG EGDTSREEFI FLMGGWRDTS LHDVWRMNSD GKWELMKEAA
PWEPRAWFSL VSFDSRTNGD VQLGPRLWVL GGGIVGNGIE KMYPFSDVWY TRDGVEWIAA
SSNASGISTA EWSMVTQSNA QVCMVNRAYY CHTSCTNEEG TISLANQLIP VCNPSTTLPE
IPAQHTVLLN NSMITKTIYP DGCAQLYQRF FFWPEMSASR K
//
