ID H3GSM3_PHYRM Unreviewed; 2213 AA.
AC H3GSM3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra80018, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra80018}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra80018};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP
CC route): step 2/2. {ECO:0000256|ARBA:ARBA00005142}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS566042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 164328.H3GSM3; -.
DR EnsemblProtists; Phyra80018; Phyra80018; Phyra80018.
DR VEuPathDB; FungiDB:PSURA_80018; -.
DR eggNOG; KOG0059; Eukaryota.
DR eggNOG; KOG3370; Eukaryota.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; H3GSM3; -.
DR OMA; CYNETWF; -.
DR UniPathway; UPA00610; UER00666.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006226; P:dUMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046081; P:dUTP catabolic process; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR008181; dUTPase.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00576; dut; 1.
DR PANTHER; PTHR19229:SF36; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF00692; dUTPase; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1088..1107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1295..1323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1351..1371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1391..1415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1427..1447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1507..1528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 700..933
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1571..1805
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 2213 AA; 243934 MW; FCAA66AD52EB5C0D CRC64;
MDQPLTVNAP ASPSTKRSNL RFVPVLLRKN WLLKRKHPVA LFFEVFTPVL FIIVMDIVRT
TSSDKTVPSG FTTGTTSYNL FSPAGWSLVG PTTTPMFATP ETTLSGLMLH LGYLSFDYGR
LMKTFTSENR SICERDLALG GRVSLNTSSP YALPSECEGR VSPFKFAIAP DDDFTRNYFY
ETMKLWYPTV VINDSSNASL VIPSFEDSTV FFDTEEALEK YVESSDYAKT SAQPRIFGAI
VFAEHPTDAN AIGQPSSIEY TLRLNSTYVG NSDDNRYIPR TVGGDGASLW DSFERKLETT
DYQQYTTNGF MTLQTLVTRF VNCLPDWDAD TKTTTGSCQI NSSTAISSSD LDVRLLEAIV
NDSATKYTGV LFSELLGETS PLSSAVTDLQ LDNATREALL TPLRQAPQPY LGSLTTPFPI
NSFASSSFYD AVTDAFPIFF ILTYLHPLSK ILVGLMSERE TRSRELMKIL GVKESSIVIS
WYITYIVILF ISCVLQALVA VAELFPNTSV VLLFLFFFLF SMSVLAFAFM ISSMFSRSRT
GVYVGFITFF IMYGVTGAFS DSSSESSKNI ACLLAPAGLV FGVNSLSSAE TSQVGISFAT
ASQRINNFRF ATALWYFALD TILYTLLGLY FEKVIPKEYG MPEKWYFPLR PSYWRRPRKF
LTSTTPRLNE NEPAVAVEVN PNIEPVSADL LDQERSGEAL SVQGLRKVFP VPGGQKEAVK
GLHMNMYSGQ ITCLLGHNGA GKTTLISMLT GVTPPTAGDA TFHGLSFRED IDEIRESLGI
CFQHDVLYPE LSVHDHLEFY ARIKGYTGGD LADEVTAKIR EVGLVDKRDT ITSALSGGMK
RKLSVAISLL GDSSLVFLDE PTSGMDPYSR RSTWEILMDN RQNRVMVLTT HFMDEADILG
DRIAIMGEGE LRCCGSALYL KNQFGVGYNL TVVKEENCDD SRVIEFVSRY VPASHVLSNV
GTEIAFQLPL DSSSKFPAMF RKLDENLQNL SVLSYGISVT TMEEVFIKVA EVADEDQQHT
LQNTVKQHPV NSQDSIPIVG DKPADGHYHG LGHTGSSLPL GRSRSVFVTQ MVAMFQKRFR
MAKRDKKLFT VGLILPVLWL IFGLSILKGA GLTNNDPFLA LELSGLEDEA GNVLVPSFCE
QSSGSWCETA LGSDYFSGAS IVTLSADDIG DPPYSSDSPS VFDVVYDNPT INATDTTGYQ
LKISQEIFNR AFTNRISDQF GGYLIHADVD SNVFGYNVLI NTTLTHGSVV FKELMDQSLY
RLMATQHDSS IGASDLSLTV NNHPLPLTAE NTALFSAYIS FTAVLFIVIA FAYYPASIVV
MLVRERSPDH NSKHQQLVSG VGINAFWTAN YIWDFAVFLI PGVIALALIQ AYDLSTLTGS
SSCVTCQDST FIAVIVLVLV FGLAICPHAY CWSYVFKDPA SSQTYMILIN FVLGLALMVV
SFVMQVIDST ESADKALQFI WRFSPLFCLG RGLLNLTIIE ITHTGGAEAD NELSKDPFAL
ENTGYEIIYL LLDAVLYYAI AVGIDYAMTF PKIKSALSKD PDISMEKRVI DEDVAAEVDR
VLMGGADTDM IKLQNLRKVY HKGEKVAVHD LSFGLKQGEC FGFLGINGAG KTTTMKMLTG
DIVPTSGNAT LSGFDILTQQ VEVRRQIGYC PQFDALIDLL TVKEHLELFA KIKGVPSTDL
AFVVREKIEQ LNLTAFEDKL AGSLSGGNKR KLSVAIAMIG SPKILFLDEP STGMDPVSRR
FMWDVISEIS TYNKESTVVL TTHSMEECEA LCTRVGIMVG GELKCLGSVQ HLKNRFGDGL
MFDAKLQAPS SETVTGLAMR HFDSLDARIE AKDLPEACQL FGNASWEQKI VNTHPTGHTI
ANLAKRDGYI SVSSFAAWWV TETQFEDVSA FLQESFGSIE LLERQNDSCW FKIRDQSATN
STLRLSNVFE LVENAKTRLS IREYSVSQTT LEQIFNAFAS QQDADEPCSS TLFRTFRTMA
TKRTRSAPVL RVKKLSPEAI LPSRGSSLAA GLDLSAAYDA VIPAGGKGLV KTDLVVAVPA
GCYARVAPRS GLALKKFIDT GAGVIDADYR GNVGVILFNH AAEDFSVKRG DRVAQLILEK
IEYPEVQEVD EIEDTARGAG GFGSTGVDLP IAKKQHVEKN AEQDGEFDVA VGILEILSDK
KVLNKETRVQ LKKKLFTATE RQVKLLNKAL EEFVKDEDVD KVLEWINAFL EAK
//
