ID   H3GTI0_PHYRM            Unreviewed;       808 AA.
AC   H3GTI0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=PX domain-containing protein {ECO:0000259|PROSITE:PS50195};
OS   Phytophthora ramorum (Sudden oak death agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra80440, ECO:0000313|Proteomes:UP000005238};
RN   [1] {ECO:0000313|Proteomes:UP000005238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX   PubMed=16946064; DOI=10.1126/science.1128796;
RA   Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA   Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA   Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA   Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA   Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA   McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA   Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA   Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA   Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA   Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT   "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT   of pathogenesis.";
RL   Science 313:1261-1266(2006).
RN   [2] {ECO:0000313|EnsemblProtists:Phyra80440}
RP   IDENTIFICATION.
RC   STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra80440};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; DS566046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3GTI0; -.
DR   STRING; 164328.H3GTI0; -.
DR   EnsemblProtists; Phyra80440; Phyra80440; Phyra80440.
DR   VEuPathDB; FungiDB:PSURA_80440; -.
DR   eggNOG; KOG2425; Eukaryota.
DR   HOGENOM; CLU_349008_0_0_1; -.
DR   InParanoid; H3GTI0; -.
DR   OMA; HESTHNQ; -.
DR   Proteomes; UP000005238; Unassembled WGS sequence.
DR   GO; GO:0090730; C:Las1 complex; IEA:InterPro.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR007174; Las1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   PANTHER; PTHR15002:SF0; RIBOSOMAL BIOGENESIS PROTEIN LAS1L; 1.
DR   PANTHER; PTHR15002; UNCHARACTERIZED; 1.
DR   Pfam; PF04031; Las1; 1.
DR   Pfam; PF00787; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT   DOMAIN          20..158
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          714..746
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        714..731
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   808 AA;  90746 MW;  42A25A139774BCA6 CRC64;
     MIDEDSISVV ITASKEVEGG EAPDSDEGGA KLHAKGHKYT MYTVFVRNLS TGGKCVVRRR
     YSDFYKLRKE LMELVSWGHC SYCEQYLQQI ADYPFPRRRL LRSSRAAVVK ERMDSLGLFL
     RHMLLCIMAR SFEDCTQACE NIESCILKSF LQMEQTEILF PTMASKQRPI EILQAMEEKR
     QQQIKAAGLR TKSLAYESDG LPPSQSRNHR QVGTDTCHLC LQKWTHCYCN SDQDSVYPVN
     VAAASESSAN ERPSVSIADS DASRCSRCEN DWNHCYCCQQ VSPTASSDVH AGLFNSDPYA
     QQRVVSRVAS WRSRVQLPVA IDATAQLVEL QLHEQMAQHH HHAVGVSSRS HMELSLLYAN
     VIVRCVNGLV DGSQKGMYAT AVSTLAQRIG IPLWVVDLRH ESTHNQLPSL PVLRFAARHL
     LAWLRVNYWG AQEDSIRGQV HQAAQWLFEQ LPHLNKQPAG GEMQVDEVQG SDVQMQNTLK
     LILDVDNLRN LVVPLLVVGE QYGERVVPTG LLFLEAPPLP EEQEAEIFQK ETFVSLLLQV
     QPLWRSFSAS LLARLCRTVF ATICSKSRCQ SEDDNEVSEE LEQTAKTFKV NEVEMALQWI
     KFMVSSEYRE RIKLQIGPIE DLCQCGAEML ALAEKLKCDN AADDDAELLE RLLTVLKSTK
     GIRNHSLLST EAAIATSLAA DSSSGWTQLP AWSESPIGLR HCYTSYHNSN QSQVCESGSL
     DDDSLTPDST TFVAPDEEED EDMNTDAHDT EKAIDVLMED LDAVYDTDVQ RSLDLQAAIA
     RDGLRQGGST VVLPKQELQR IQEEIEIW
//