ID H3GUH6_PHYRM Unreviewed; 1089 AA.
AC H3GUH6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Ribonuclease II/R domain-containing protein {ECO:0000259|SMART:SM00955};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra80881, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra80881}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra80881};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR EMBL; DS566051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GUH6; -.
DR STRING; 164328.H3GUH6; -.
DR EnsemblProtists; Phyra80881; Phyra80881; Phyra80881.
DR VEuPathDB; FungiDB:PSURA_80881; -.
DR eggNOG; KOG2102; Eukaryota.
DR HOGENOM; CLU_002333_5_0_1; -.
DR InParanoid; H3GUH6; -.
DR OMA; VKVHMDS; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0004519; F:endonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 543..921
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 365..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1082
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 121817 MW; EBCA897BE6CCA1FE CRC64;
MEAVDTPPTW CLDELNVATR RGRIVRKVRE RYLRDDLSCS LPNCALCSAE DDASAATHVL
GTTKTVLADT PRDGVYLLPS MKTFLLQMDV LEFSTKKKTK VDTSGHQVFA DVLVLETVWE
FVKRQDLGVY NRLRALLMNV DRRFVVFANE HHRACYVQKK QLLPRGYQED SLEDQVSIET
EDERNERAVA TAWRWYAEHL KQLQRQDVKV LFLANDAEDL QHAEKFGVVG GKTIADFVKP
VAAQFPELQD LLSASAAEEK EITAEGVSSS AGRHSKKKLY PEHMSAAELL AGIKNKRYFK
GTIRCNRDHW LECHVLIHGA NGVKIPVLLQ GREHINRAID GDLVAIQLLP KEQWKKPSDS
FAANGTAAAE AAEVADDDKE DVAQPEPVGV AEPTVSLEQV ALVQSDASQH AKPAGRVVGI
IQRNWRKFCG SLEAPRDGAT FNASGSCLVV PVDRKVPKIK IQTRQQETLM DKRILVAIDS
WPADSKFPLG HYVRTLGVIG DKETETNVLL IEHDIPCDQF SDEVMRCLPA EDWKITAENS
TGRRDLRDLP VMSIDPPNCK DIDDALHAKL LPNGNLQVGV HIADVTHFVA PGSPLDEEAA
DRGTSTYLVD RRLDMLPGLL TTKLCSLTDV EDHFAFSVLW ELKLVGNNEV QVVDVDFCKS
LIRSVASLSY QQAQEFLDDP DAGGVHGQDD KPKKKKKGES DKEFERRQLL GSGIKTLNVI
ATRLRAKRIE AGALTLASPE VRFVLDTETQ NPLDVQMYTL RDTNALVEEF MLLANITVAK
KIVRHFPTFS MLRRHPAPSK RQFDLLCSQA KAVGVELHVD TSKQLQDSLD AADMQALEVA
KGGSKGKRKH GNKANPYFNK LLRIMTTRCM MPASYFSSGE IAPPEFHHYG LAAPIYTHFT
SPIRRYADVV VHRLLAAAIG VAPLPGYLEN KSHLNDISDQ LNRRHHAAQL AGRASVTLHT
VLYFQQYPTR TDAVITKVKN NGVGVLLPRF GIEGMIFLCD KDEQDDEDVV RFDGNHHTLT
LVQKDNRKLQ VFDRVRVKVY VALTFGNRQE LKMDLLDEDD DEDDNQNDKA QKEAEANLRA
ARKKRKVAA
//
