ID H3H0Z0_PHYRM Unreviewed; 1304 AA.
AC H3H0Z0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra83858, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra83858}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra83858};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; DS566095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 164328.H3H0Z0; -.
DR EnsemblProtists; Phyra83858; Phyra83858; Phyra83858.
DR VEuPathDB; FungiDB:PSURA_83858; -.
DR eggNOG; KOG1474; Eukaryota.
DR eggNOG; KOG1778; Eukaryota.
DR HOGENOM; CLU_003823_0_0_1; -.
DR InParanoid; H3H0Z0; -.
DR OMA; HAQNSSC; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR GO; GO:0004402; F:histone acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR031162; CBP_P300_HAT.
DR InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR13808; CBP/P300-RELATED; 1.
DR PANTHER; PTHR13808:SF1; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF08214; HAT_KAT11; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM01250; KAT11; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51727; CBP_P300_HAT; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 455..527
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 726..1186
FT /note="CBP/p300-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51727"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1243..1267
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1304 AA; 146734 MW; 0FBAF8535D93077A CRC64;
MEVHEAASRL LACPRLSRER EAERQRAIHR PLAVNWREKV EVNGQEEEEE QDAAKSQVKR
PLNVKKELPA PGPEVVTIDS DSDDADEAPY EVEESVRTKR KLEELSVPVE RKQHRHQVAT
KDKVVWEQLH VAGVRRRRLG EEDAAFLLFY GDRETPSAGI LRLIVGSTDE FLTRFVKYLL
WRKLSAAVDA GLVSERLVQS EWTKIVFSCP VPPHRRRSGP MPRPELLPRP VTITVRPLQF
ARRQPQRRSL CVVNSSAELA TKQEPLSPRT TPEEAAIALA NRLAGKGARK SSAKSPKKSS
KAPQTKSPRG EVRKRPLGGS TYSEGVAGVN GYSQAAGFSP RKQRRRNGEV SVPPVTPRQV
VRAKGSGGKS ISQKLMEPLP YDCRTLGENR SLPLGWRPPG RCGGEASHAL DPVEVNPMLQ
MTADEIVQHI ASVRREGRFT SFEKVTDILL KLMSDPRNRH GVFNMPVDPV ALDLPTYTMI
VQHPMDLGTI KRNLTAGEYL ELEDFVSDVR LVFENAMLFN PESHYIHVDA ETLLKRFNES
VKAEQNRQAK SKRVQHVCLV CRGNTCIVCN QQCLPITQPH LQCSAGCSTD IRKGSVYFIS
EDGTRVWCQK CKTRLARDRS STDRMTDDTN SFLDSLIKMK SEPSVEPWVK CGECDRWLHQ
VCGLYNPVIG AYETQKAQTP EPGGLVMETN PYLCPLCRCR RKRAIPPPES PMRTILNADL
GEHARSSSCL NIPSCELSIF IQNFLRRGLR DIGEHEAAQT LHVRALSFPG ERMTVPEGVV
QAFDENAELL AQLRPGTDTS AQRLPAHVSY LSRGLYLFQK HEGMEVCLFT IFAQEFGDDC
ELAANRRAVY IAYLDSVRYL KPASARTAAY HLIMLAYFDY VRRHGFSRVH IWSCPPQKRI
SYVFWCRPIF QKTPSAEHLR RWYNKLLTKA KEHGIVKGWS TMHDRYFSES VCSSTAADDS
KPPASFVSMK EESGVGVSTR GTTVLSVNPD ELVWPVNQLP PIFDGDIIPS ELERILGRII
SRNEKQKRAS ENKKLAVRGK SSSVARAGGK LSVGNVVTRI KDEVSTAQTA APPSLQLDVK
VREVFAKCQF AVQRLKQDLL VVDLEVPSEE ETKEDQVGTG FAGERHTKGC HPETLVPSWY
GQVPRFFGSR FMFHQLCSYS SYQFDSLRRA KHSTMMMLHH YFNERVVQLN VFCRECSLLI
TRADFWSCRS CERYALCDAC FRRAGNEHPH QLVFGPAPPF PPRIQQMPEH PAAPVPLSPP
PPQQQQHLAP QRPNLQSEQV QSVASATSVQ PSALSPTVNV CELC
//
