ID H3H4X6_PHYRM Unreviewed; 1649 AA.
AC H3H4X6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra85648, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra85648}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra85648};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; DS566263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblProtists; Phyra85648; Phyra85648; Phyra85648.
DR VEuPathDB; FungiDB:PSURA_85648; -.
DR eggNOG; KOG1075; Eukaryota.
DR HOGENOM; CLU_002086_0_0_1; -.
DR InParanoid; H3H4X6; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09279; RNase_HI_like; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR35450; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR35450:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT DOMAIN 310..443
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 866..1149
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 163..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1621..1649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..643
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..665
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1649 AA; 181734 MW; 916BEA29B02C07F0 CRC64;
RAGGKRRRLN AGDDEDQREL AELLLVDEDK AGAEHPALRL PTASAHPASV LSVYAHAATR
FDCTLCTYTA ASLASLKRHR SSRHRRTAFL DKFLAGCACG TPFASRLAAA RHAQACANLC
TTSATTSTAA KASSPTAAGG RPTVRAVVTA APDLPRQYPS ELVASPPQPS STNVAMQDQV
DAEQQARNRW GPPLPRPLVA SRVAARLGEV PPPRWGPPLP RGVVVSRIAA RLEAVPVPRG
GPPLPRSFVA TRIADRLAPP SPDLSLLDEE MKESEPPDPT HHSADEDSTD AETADAVMEP
AFVSDPPTAT PREWRLQFDG ACRGGPNPGG AGALLYNPEG AVVWTGSHYM PGAKETNNSA
EYTALLIGAR AAADHGARQL RIEGDSLLVI RQVKGLYATK STRLRQLRNA VRHELARVGQ
HSLHHIDRQG NAFADRLANR ALDLKSDKVE CKEHPVAGAC TTCMGSPSAG PPATPPPTTA
DIEMADAGSD DELRADIDDG EVYAPMRLEP GVIPTRRSRL RLRQLTDDEM EAAGEVVERL
SAGLSAKIAD ADDWETAEGY ITALPYMLYD KLQQYTQVRH GTARSPAPHP QRRDVQGQVE
THREPRHETI GQPDQPGEPS PTRRRRRGKR KGRRQRRHPR RTNCGGGGRQ QRKQRHPRPP
RGTRHHREHR IDEAIDELHA LERARPQARP AIAKARRRVG RIRSAIDQQL LRHRFDTAEK
ECVDGILAAA RTARDARTTV RAAAATGTTA TPETAVTSGT EQQDDNGTCP IPSEVLWRHF
DSVNTPQRDF DPEAPEGAAF RSAMARLPAA TRFMELLKEE PSTDGIEVQL QHASSTSSPG
LDGVGYDVYK RFASQLLPVL KAAFKCCWTH KQVPQSWKLG VVRLLYKKGD REDPANWRPI
CLQQAIYKIY TGVLARRLTR WQDANDRHAP GQKGFRPVNG CGEHNFLAAM LIDHARRKHR
PLYEVWYDFR NAFGSVPLGL LWDALERTGV PAEYIAAVQG LYDHAAFMVG NAVDGSTAPI
LQRVGVFQGC PLSPPLFSAA ISPLLHALQL LPSSGVQLSG DDRPGVSAYA DDLKTFSGTK
AGVTEQHELV AMFLRWTGMA ANPAKCRSMG VRRNGNGAIE ADHLELALDD TPIPTLTHLQ
SYTYLGIGDG FDHVRRRVAL APKLKLLKQD ATALMESGLA PWQVVKAVKG YLYPRVEYAL
RHLRPDDQLL ESFDLHLRRG LRHLLRLPKS ANNDFVYAPV SRGGLGFLPL VELHAALQIA
HGWQMINSPD PAIRRIAREQ LHQVADARHR LDKDHWKQRG DELCELLLNG ELGTSAHAPP
KRRNGDIGSL WVDVRKNLKA FGLKLATAPA DPESGAPAKP LQLCVPHHAE WLDHRNVLRH
GRTARAHGGV GSGFLTRPRG MWESDYRFAV AARLNMLDTV NVLARRRLRA HDRCRHPGCR
WKETLAHVLN HCPGTMDSIR GRHDDALKEI ERTLHASSGD RQGRTELRTN QTVPGLAGPA
LRPDLQVYNH DQRTVAVVDL AIAFDEQPRD DPESSGLAKA AAEKKAKYAG IKRHLERQGW
KVHLSALVYG SLGSVAPSNY KVYTEHLGLL KRDAKRLDRQ LSVACIQSSR RIWNLHCAQH
RARQHQDQPA PRGRRVTETG GTPSRTDRR
//
