ID H3HCE5_PHYRM Unreviewed; 2336 AA.
AC H3HCE5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra95097, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra95097}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra95097};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS566028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblProtists; Phyra95097; Phyra95097; Phyra95097.
DR VEuPathDB; FungiDB:PSURA_95097; -.
DR eggNOG; KOG0498; Eukaryota.
DR eggNOG; KOG0500; Eukaryota.
DR HOGENOM; CLU_000527_0_0_1; -.
DR InParanoid; H3HCE5; -.
DR OMA; FPAEMES; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 4.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 4.
DR Gene3D; 2.60.120.10; Jelly Rolls; 4.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF00520; Ion_trans; 2.
DR SMART; SM00100; cNMP; 4.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 4.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1225..1244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1285..1303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1327..1345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1357..1376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1881..1905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2055..2076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2082..2103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 481..545
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 982..1050
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1462..1563
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2182..2296
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1729..1764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2336 AA; 265310 MW; 6A9377219D9792C3 CRC64;
MTRLSAMRER AASTAPSGGE AWKQSEWGGP MGKIINFCRR RKRGLFVGMV VLELFYVFVS
VPLRIGFLFD PYSSKTWSTG WTTELTVLTV LDVLADAASF ASLLDIFAAQ RREQAALAAD
ATGAIGIRRQ RTTQGPKPTE RRSSLLSRMR DSMLVAWSLN TILPASHSHR GIQRPVLIEI
TSMVPLELLA LGFGPNSLHL LRMLKLLRLY RVSGCARELK QMYTGSKIVQ KLEYTGNAVL
FNTVALGLAA CHWIACGYMA IAHLECGIDF MLCSKAHIVL RTIPGAGEHG TAEGITGVSP
TGDGSGYTCW AIEDYLVGTG VGRKYGRAAY WAARSVMTTG FYDVGATTNA ETLYVIFAQI
VGAIFSTAVL ATFLFIFRYR NARMQEFMAH VDNANEYMQM RHFPETVRDG VLGYYKNAWA
THHALRHDEA IERLPGHLRA HRIQNVAFLA KESVEFVNTL ALRIEYCVYS PKDWVIEKLP
DGMYFVLRGS VKLDGPAHPM AHFAKTGDHF AEGCLLFPGR TDERARAQTF CDLYKLPQRA
FYKTLTIFYR ENAPKHLEDM RSKHARRDQQ EQKMKKMLGR SSDNVTGAAN SHTSSTGRFS
VTFGSDHIPW RTPGSNFRKW WEHARLFSIV FVIFEVPLYC VFDADTFPFG EKSKYSLQSM
TSILVEGFFI ADFVFRARFF AYIDQLALIT VSDPSYIFDA YRESGLWRDL LAILPLPLVV
EFIVKRGSGW TMWLHMSRLV RLFRARYLQQ TIVEFAHLRA ISSKIQQAGT MLLYVSITLH
VAGCLWFLMA RFSVLEEEFE PIVEEFTRDR CLRDAGLHGN CSWTLYDAYG QIGTTFKVQD
PASIYTVKMA YVRSIYWAIV ALTTVGYGDV VAFSTYESYF AAVWCFVGGL INYGVVGAMS
NIISNLTASS RHHSEKMNTI NVTLGHFRIS ESVRARIRQF YHQQLYVQKV TSEAQLLDGL
PMQLRHRISS ILHAESVRKV PLFIDAQNER LLYELTGLFR RQLFQRGDPF FAEGTLCEEM
YVVVSGRANI FSKRLGTVPV GALSAGDCFG VFTAATVVDA SVITYTAFVA KIERHFPAEM
ESLRMQATQQ HIFDMLTLEA VIDNIKSRST LSKFTEQCAS MFEEKENWTQ QRLKMRLRLY
WDLIVLVLDI YNAFLVTFRI GFLAHPSSGL RMGLVVSDFV GDTLLAADIY LKLYFFECEE
VGLNNLISRE ERSTTYTGHE LRGDLLSSLP LYYVGSSFLA MSLCRLPRLL RLRQVPETID
SLIMRLQQRF ATGGNISAYL SPIKLVLILL FTGHLAACVF YLICHTDHNP KSWTHHDPIV
HMEHESIGVL YLRAFYWALT TLTLVGSREI VPLGMAATIW ATFTCLCCAF IVGHIVGELS
ELILDMDKTK KEFKERESHF DAFARDHDLP ASIRTRVLHY LKFQHHYLKG LDIYDTFSDL
SPNLRVQLMM DLHGDTLQNL CIAPFLNQAQ INGLAVRLKS ELYIPGDTII VEGDLGHKLY
IVKGGTGMVL WKSTGTAVAT ITAGSLFGEV AFFLRGQRRI ASVQATTCSE LLVLGRRAWE
ELLASSPREE AESTERALVQ WVQYCLKGYN IMTVEIVKDI KSGGGDSGRS KQPKLIEELR
DLNANSQLYP VILYRWVLNN ILPSGRKSAK LGRVYADTSP GTPSLPLIRS KSFKNGTSVQ
INPVSRSMRE YYREDQLVEM EDECWRRYKV SLFMAEAFTV AVVEQTPPAN YESRNRPSQR
GLREKRQPRG SIGRHQDRNG HGHHLHQSFG LAVLPSGAAR AHRRQRKLKR SQSLPLFDRH
FALMIRDELQ DSNAKESDSK LNLGFELLQR CRQSEFSSLF QVYLSWLKRT DRWNQWGKQQ
LMSTSTKAED FVNFLSRCYR LWEWVIVCVG GFYAVTIPFF VYLALKHSAF RRVLYLSAGG
STDIPVAKRR APTVAASLSS AGTSTLVDHR WFYMSLFQMN KVPRIVESIE ASERLTQFLA
ADLNLPISES RLHFIRTVAV YVLSGHWIAC LWFRLGLHAY EIYGASWLST YKMLPVDGFG
TLSEVPTSRR YLRSLHFAIG SITTVFYGDV VSMNVIETVV EIAFIVVCIL LFGVLVGAQG
ELIEANYKHK MLFEQNLMEL YNFLQNNDVP RDVRQRLRLY YTNTWLKYHG HDDLEGVRGL
SSLLVEDIAQ YTLRNFANRV SILKSCDESF LRSLLTCLKH IICSSAEAVV RKGDVDRSMY
FIAKGKVLVQ GPGFELVKHE GDFFGELSLL YGIPRSATCS SLGVSLLYVL EWETYEKLLA
DYPEYREQNR REWVIVSTVL KTGESRFRSI IDIVARMEKV NWVLVDEIIR KAKSLK
//
