ID H3KDP9_9BURK Unreviewed; 783 AA.
AC H3KDP9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=TrkA protein {ECO:0000313|EMBL:EHY31745.1};
GN ORFNames=HMPREF9440_00861 {ECO:0000313|EMBL:EHY31745.1};
OS Sutterella parvirubra YIT 11816.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sutterellaceae; Sutterella.
OX NCBI_TaxID=762967 {ECO:0000313|EMBL:EHY31745.1, ECO:0000313|Proteomes:UP000004956};
RN [1] {ECO:0000313|EMBL:EHY31745.1, ECO:0000313|Proteomes:UP000004956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIT 11816 {ECO:0000313|EMBL:EHY31745.1,
RC ECO:0000313|Proteomes:UP000004956};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHY31745.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFBQ01000119; EHY31745.1; -; Genomic_DNA.
DR AlphaFoldDB; H3KDP9; -.
DR STRING; 762967.HMPREF9440_00861; -.
DR PATRIC; fig|762967.3.peg.686; -.
DR HOGENOM; CLU_005126_9_1_4; -.
DR Proteomes; UP000004956; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF1; CATION_PROTON ANTIPORTER YBAL-RELATED; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004956};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..423
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 468..562
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02254"
FT REGION 620..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 81244 MW; 021F62575D1CD4E6 CRC64;
MEHGLPLIST LVIAFSLALI FGFVCERFLK SPALVGYLLA GVAAGQHTPG VFADPALAHQ
LSEIGVMLLM FGVGLHFSVK DLMSVKAIAL PGAVLQMAIA TVLGAVAVHF FWDWAWGQAF
VFGASLSCAS TVVLLKALEV RGILTTHDGR IAVGWLVVED VATVLILVLL PPLAGLILGP
NSAAALAEHA SDAVSVGDVA GEVVSAGAAA LSGEPAPAAG AEVSLLREIL ITFANVAAFT
AVMFVVGRRV LPWLMTQVAR TGSRELFTLF VLACALGVAY GAAEIFHVSF ALGAFFAGMV
MRESSFAHRA ATESLPLQDA FAVLFFVGVG MLFDWHILWQ APFEVLAVLA IIIFGKSLAA
FSLVVVMRRP LGTAITVAAA LAQIGEFSFI LIGQAAGMGL ADGHAVNLVV AGAILSIALN
PVAFMLIPKV EKALTSRFAW ARKAAMLEAP METLPEETPA ETLLGQTLVM GRGAMFAPFV
EALAQAGEKL VAITPDQADA EKLSEENISV ICGDPADVRV LVGAHIFQAR NILLLSNGPE
GVAILETIRS ARTDLPVTVV TKNGAFWAEV SSGLLEGVKM LSVESAAVSG LVHRIRKADA
AGEVPGDVIV TAQMAKREAQ RQAAEEEARK VEEAKRAARE GQQEGAEGAE AAPEAAEAEK
TAEAAPAAEV PRADAPVAEP VKAAEPAAEP ETPKVVEAVP AVPAAPAVQP AEAGKPDEAA
PVPPTVEPLM PEPDETPVAA EKTEADGKAE LAKKAKDAAK EKAAEAAPSA KTILGKLPKL
FGQ
//
