ID H3KFM2_9BURK Unreviewed; 606 AA.
AC H3KFM2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Adenine deaminase {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenase {ECO:0000256|HAMAP-Rule:MF_01518};
DE Short=Adenine aminase {ECO:0000256|HAMAP-Rule:MF_01518};
DE EC=3.5.4.2 {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
GN Name=ade {ECO:0000256|HAMAP-Rule:MF_01518};
GN ORFNames=HMPREF9440_01541 {ECO:0000313|EMBL:EHY31089.1};
OS Sutterella parvirubra YIT 11816.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sutterellaceae; Sutterella.
OX NCBI_TaxID=762967 {ECO:0000313|EMBL:EHY31089.1, ECO:0000313|Proteomes:UP000004956};
RN [1] {ECO:0000313|EMBL:EHY31089.1, ECO:0000313|Proteomes:UP000004956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIT 11816 {ECO:0000313|EMBL:EHY31089.1,
RC ECO:0000313|Proteomes:UP000004956};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000479, ECO:0000256|HAMAP-
CC Rule:MF_01518};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01518};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenine deaminase family. {ECO:0000256|ARBA:ARBA00006773,
CC ECO:0000256|HAMAP-Rule:MF_01518}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHY31089.1}.
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DR EMBL; AFBQ01000227; EHY31089.1; -; Genomic_DNA.
DR RefSeq; WP_008542559.1; NZ_JH604981.1.
DR AlphaFoldDB; H3KFM2; -.
DR STRING; 762967.HMPREF9440_01541; -.
DR PATRIC; fig|762967.3.peg.1213; -.
DR HOGENOM; CLU_027935_0_0_4; -.
DR OrthoDB; 9782972at2; -.
DR Proteomes; UP000004956; Unassembled WGS sequence.
DR GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR CDD; cd01295; AdeC; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR HAMAP; MF_01518; Adenine_deamin; 1.
DR InterPro; IPR006679; Adenine_deam.
DR InterPro; IPR026912; Adenine_deam_C.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01178; ade; 1.
DR PANTHER; PTHR11113:SF2; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR11113; N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE; 1.
DR Pfam; PF13382; Adenine_deam_C; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01518};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_01518};
KW Reference proteome {ECO:0000313|Proteomes:UP000004956}.
FT DOMAIN 89..371
FT /note="Amidohydrolase-related"
FT /evidence="ECO:0000259|Pfam:PF01979"
FT DOMAIN 423..594
FT /note="Adenine deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13382"
SQ SEQUENCE 606 AA; 63688 MW; FC75953EDB76B21A CRC64;
MSASSHSNAS SPVTVTLTPA NFDALRRRID ASNLAVPADT RFTGGVVADV YTGEFVKGVD
VLVKDGLVAA VVPEGIGEAR ETVDLQGKTL LPAFIDAHVH IESAMLVPER FAELVVPHGT
GAVVADPHEI ANVLGTVGLD FMLEASEGLP LDIRFQLPSC VPATPFEHAG AVLDAAALEP
YWEKKRVLGL GEVMNIPGVL GHDSDLAAKL LHAQKRSRPI DGHAPGILHE ARSATAAAGI
TTDHESSSLE EMRESLARGM KVIIREGSAA KNLRTLIQGV TPRNSRRCMF CSDDVNPADV
ERLGHMEKHL RMAVEAGVDP MTAVQMATLN AAEHFGLPGG AIAPGKPADF AVVEDVTTFR
VAETWHRGEL VAKDGKLTKP IRTPIQPEAV LSRVKLQPVG LETFRLPVPS GEANVIGIVP
HEIVTKAEVR TVKTDAEGNF DAQLNPGLVK LAVLERHHAL GTVGLGILSG YVAAGALMEG
AVATTIAHDS HNIVCAGGSD ADMLAAVRAL EALGGGMVVV KRGEVVASLA LPAGGLMSFE
PADAVARGVA AVHRAAEEAF RLGEGLEPVM TLAFLALPVI PELRLTDLGL FDVRAWTHVG
TDRGAK
//
