ID H3NH24_9LACT Unreviewed; 564 AA.
AC H3NH24;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9708_00163 {ECO:0000313|EMBL:EHR38079.1};
OS Facklamia languida CCUG 37842.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Facklamia.
OX NCBI_TaxID=883113 {ECO:0000313|EMBL:EHR38079.1, ECO:0000313|Proteomes:UP000006190};
RN [1] {ECO:0000313|EMBL:EHR38079.1, ECO:0000313|Proteomes:UP000006190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 37842 {ECO:0000313|EMBL:EHR38079.1,
RC ECO:0000313|Proteomes:UP000006190};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Facklamia languida CCUG 37842.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHR38079.1}.
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DR EMBL; AGEG01000002; EHR38079.1; -; Genomic_DNA.
DR RefSeq; WP_006308028.1; NZ_JH601133.1.
DR AlphaFoldDB; H3NH24; -.
DR STRING; 883113.HMPREF9708_00163; -.
DR PATRIC; fig|883113.3.peg.160; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_1_9; -.
DR OrthoDB; 9804124at2; -.
DR Proteomes; UP000006190; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006190};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..214
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 252..553
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 564 AA; 62899 MW; 9BD0251D5847C16D CRC64;
MNPEHQEKIN QTQKNLFYLS IGVILIALIF MARFAQLSLF KTVNQVDLAT YHQARPERSS
IIEAKRGSLF DRQGQPIAMD TTSYSLFAVL GGEWSEGNVV QDKDQTARVL AKYLEMDQGA
IYSLLNQTGV DQVEFGPAGQ NLSPRTKEAI EAEHLAGIHF NSKTSRTYIN DYFASHLIGY
VKDLPRDLLN QPHFIGEMGI EAAFDPLLSG QSDGEEPAIG QDLYLTLDTR LQNSLEDSLD
QVYVRYQPKS TAAYLVEAKT GRLLAAGQRP TFNLNSRQGI EDLWQNLLVE TAYEPGSTIK
VLTMAAAYDH HVFYPGETFM SGKVEVYDQT VREYNRFGWG EISFEEGFAR SSNVGMVELV
NRMGNQTWAQ QLEQLGFGQT TASLLPNESA GTMDFSNPVS RTMSGFGQAI SATPLQLMQA
FTSVANDGMM KKIQYIDHVG QEENDRYQVQ DLGQMFTPEA CRAVRQLMVD SVNKPYGTAT
PFKSDETQVA AKTGTAEIAN PDGPGYLQGE KNFLYSVVSY FPAEDPEYLL YIFVKQPQQL
NGKIGTQIVA EVFHPIVKSV MINQ
//
