ID   H3NLP0_9FIRM            Unreviewed;       462 AA.
AC   H3NLP0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=PDZ domain-containing protein {ECO:0000259|PROSITE:PS50106};
GN   ORFNames=HMPREF9709_00251 {ECO:0000313|EMBL:EHR35743.1};
OS   Helcococcus kunzii ATCC 51366.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Helcococcus.
OX   NCBI_TaxID=883114 {ECO:0000313|EMBL:EHR35743.1, ECO:0000313|Proteomes:UP000004191};
RN   [1] {ECO:0000313|EMBL:EHR35743.1, ECO:0000313|Proteomes:UP000004191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51366 {ECO:0000313|EMBL:EHR35743.1,
RC   ECO:0000313|Proteomes:UP000004191};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA   MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Helcococcus kunzii ATCC 51366.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHR35743.1}.
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DR   EMBL; AGEI01000008; EHR35743.1; -; Genomic_DNA.
DR   RefSeq; WP_005397173.1; NZ_JH601088.1.
DR   AlphaFoldDB; H3NLP0; -.
DR   STRING; 883114.HMPREF9709_00251; -.
DR   PATRIC; fig|883114.3.peg.247; -.
DR   eggNOG; COG0265; Bacteria.
DR   HOGENOM; CLU_020120_0_0_9; -.
DR   OrthoDB; 9758917at2; -.
DR   Proteomes; UP000004191; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.120; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR43343; PEPTIDASE S12; 1.
DR   PANTHER; PTHR43343:SF3; PROTEASE DO-LIKE 8, CHLOROPLASTIC; 1.
DR   Pfam; PF13180; PDZ_2; 1.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004191};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        97..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          368..446
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51036 MW;  DC76A4FA6057F526 CRC64;
     MSDRYNDEFD DWLNNVDKDN RDDVPSRDLN DTDKISEVEE IRDNQHEKVY EAQNVQGEEF
     SNKQNSERQE YTNNNEYRRD INQPENKKEK KKSGFGFFRT VSLVLIGAIL GSFLGPIASN
     YLFKDNENKE VVQETQKTQP ISISTKQENN IENAVAKKAI QSVVGINVKY QSERDIFGQS
     KSSEGIGSGI IVSENGYILT NSHVLSDKSK EITVIFSDNS HAKAEIVWND SGLDLGVIKV
     KKEGLTPIEF ADSDQLQIGD KAIAIGNPVG LNLQSTLTSG YISGLNRTIT MQNGMIMNGL
     IQTDASINSG NSGGALLNAE GKLVGINTAK AGSTDGIGFA IPSNIAKSIV EKIIKDGYFE
     PIILGIRGID LVNYMQYTSR YDLGTEEGVY VVDVVAKSSA GRMGMKKGDI IVKINNDKIT
     SMNTLKQALI KYNVGDTAKI TYIRDGKEKV SEIRFDSQED LY
//