ID   H3NMQ9_9FIRM            Unreviewed;       989 AA.
AC   H3NMQ9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=HMPREF9709_00620 {ECO:0000313|EMBL:EHR34650.1};
OS   Helcococcus kunzii ATCC 51366.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Helcococcus.
OX   NCBI_TaxID=883114 {ECO:0000313|EMBL:EHR34650.1, ECO:0000313|Proteomes:UP000004191};
RN   [1] {ECO:0000313|EMBL:EHR34650.1, ECO:0000313|Proteomes:UP000004191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51366 {ECO:0000313|EMBL:EHR34650.1,
RC   ECO:0000313|Proteomes:UP000004191};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA   MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Helcococcus kunzii ATCC 51366.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHR34650.1}.
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DR   EMBL; AGEI01000019; EHR34650.1; -; Genomic_DNA.
DR   RefSeq; WP_005397878.1; NZ_JH601088.1.
DR   AlphaFoldDB; H3NMQ9; -.
DR   STRING; 883114.HMPREF9709_00620; -.
DR   PATRIC; fig|883114.3.peg.612; -.
DR   eggNOG; COG3391; Bacteria.
DR   HOGENOM; CLU_012668_0_0_9; -.
DR   OrthoDB; 108903at2; -.
DR   Proteomes; UP000004191; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR47197:SF3; PE-PGRS FAMILY PROTEIN PE_PGRS17; 1.
DR   PANTHER; PTHR47197; PROTEIN NIRF; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004191};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        224..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..168
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   989 AA;  112505 MW;  2A03CA94EDD95B5E CRC64;
     MADIDAKAEK NYKYLAFISY RHLSPDAEIA EAVHEELENF KVPRELDPDG KYKEIRVFRD
     KYELATNDLS ESLDSALLNS KYLIVISSKR TKLSEWCVRE VELFKKHHSS RNIIPILVEG
     EPYESFSEPL KNLSSIEVDD KGNETIKSLD LLAADLRPDE VKKTSFIGYE ELEKTNKSEF
     NAHIKAAKKI LKNSEIYRIM ATILGVNYGD LKQRHKERQM KLKIRLGILA ATILTVFGIA
     MTSMFIRAVN SERNATSQIS MMTLKSADQS NKDGDRAYAL LLSKEAMSYV NPKMKNYEEL
     NANYERVLND ALLTDKYSSI LSLKTGTTSP FFDISTDGKF IVSTNQKNNA VISLTSNGNQ
     IKEISFEKPI TAIKVRNNDN SIFIATSDLK LFKIDSKTFD VKDLGIKTPF GIYQMDFTDD
     GDFLIAIDKA LNIATYSTKD FKMLNHKILD KNIFRIFTLK NNKEYILNTS DGQIDIFDIK
     TGKLSKTLRK SKDKISYIAN SMSKDGKKFA YADDRNIFLY DIESNFEKVK KVDIGSYTGN
     ILLSNDGRNL YYTTMNFIDV FDLDNNEHIN FIPVGNSGIS NLRLNNEGDT LAFSIDDKNS
     IGFIEKVNEK STNKKPIVSN GSNFNDHLIS FVFSADDKYL VANSQDSTLK VISTENNIAN
     VELDGTIKAI SEDRNTVMLI DKNNNLSLYD FSKEKLIKVG TISKDLNTIY NVHSISNDHE
     YFAFSDIRYK NIKVFDKNGK TVYTTQSDQD KDTFKLTVDI EIFQDKDMLV SLNELGDLKI
     FNLKTGELIK QLKDKNEQAE KIVYSKDKSL IGINYYSKNA TIFNTETGKV VENIDGEIFS
     IIGEDGKLTT VYGQKNTLLF EYKNGEKQLY ATNYDTKGIS TRQFNDDFVS LDDRYLLTSV
     TNMALVVTDI KTGNRVRTLE TEGNFNPKGV MSGDSSKIAY EPFEDKTYIA DFYNIKELEK
     KADKMLNGRE LTETERIELG LKSRVNENE
//