ID H3NN58_9FIRM Unreviewed; 629 AA.
AC H3NN58;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=HMPREF9709_00769 {ECO:0000313|EMBL:EHR34462.1};
OS Helcococcus kunzii ATCC 51366.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Helcococcus.
OX NCBI_TaxID=883114 {ECO:0000313|EMBL:EHR34462.1, ECO:0000313|Proteomes:UP000004191};
RN [1] {ECO:0000313|EMBL:EHR34462.1, ECO:0000313|Proteomes:UP000004191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51366 {ECO:0000313|EMBL:EHR34462.1,
RC ECO:0000313|Proteomes:UP000004191};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Helcococcus kunzii ATCC 51366.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHR34462.1}.
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DR EMBL; AGEI01000020; EHR34462.1; -; Genomic_DNA.
DR RefSeq; WP_005398123.1; NZ_JH601088.1.
DR AlphaFoldDB; H3NN58; -.
DR STRING; 883114.HMPREF9709_00769; -.
DR PATRIC; fig|883114.3.peg.761; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000004191; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000004191}.
FT DOMAIN 207..325
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 451..588
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 629 AA; 72754 MW; CE9AFF97EC2431E5 CRC64;
MIKVLSEDTI QKIAAGEVVE RPASVVKELV ENSIDAGSTN IVVEINNGGK SYIKVSDNGH
GIDKDDIELA FKRHATSKIE SFEDLYKIYS MGFRGEALAS IVSVSRLTMR TKTEKDVVGT
MVKYDNNKLI STESVGMNTG TIIEIFDIFN YLPARKKFLA SDITEANKIT NLMYSFAIGH
PEISFTYIKD NREMFRTIAE DSKKSNYETL FGRDFVKNSI ELDIKSDNYK IDGTISNNKF
YKGNRSMQFI YVNGRYIENE QIVEAIENAY NNLIPAGRFP LFDIKIEVSP DLIDINIHPN
KQKIKFSFSE QLFDLLNKKI TELLYLSDEN KNISLKEKDN KVRFYELNHG DGYKNILDIF
KNDSQPKTDD SKVVDKDNTT SDATNSPIID FREIDDKLSD EKINCVKNEN KPYIVNDTTY
DFENLKQEEV SDLNEKNDKE QIKFIDEKLI FKTILFNKYI LFENNSEKKL VFVDIVRANE
RILFDREMKK ENIVSQKLLE PIIINLTKKE LDIFEQNKES FESIGYEIDL FSNNAIIIRQ
VPYFLDKPGD KTYFLELFDE ISNKNSDKTK EYLLRKTLSL SINKNTNLSE IESETLYKEL
LKTTNPNTSP HGNPIIFNID YDVFMRLLK
//