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Database: UniProt
Entry: H4F745_9RHIZ
LinkDB: H4F745_9RHIZ
Original site: H4F745_9RHIZ 
ID   H4F745_9RHIZ            Unreviewed;       519 AA.
AC   H4F745;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=PDO_0178 {ECO:0000313|EMBL:EHS51424.1};
OS   Rhizobium sp. PDO1-076.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=1125979 {ECO:0000313|EMBL:EHS51424.1, ECO:0000313|Proteomes:UP000017669};
RN   [1] {ECO:0000313|EMBL:EHS51424.1, ECO:0000313|Proteomes:UP000017669}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PDO-076 {ECO:0000313|EMBL:EHS51424.1,
RC   ECO:0000313|Proteomes:UP000017669};
RX   PubMed=22493196; DOI=10.1128/JB.00198-12;
RA   Brown S.D., Klingeman D.M., Lu T.Y., Johnson C.M., Utturkar S.M.,
RA   Land M.L., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT   "Draft Genome Sequence of Rhizobium sp. Strain PDO1-076, a Bacterium
RT   Isolated from Populus deltoides.";
RL   J. Bacteriol. 194:2383-2384(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EHS51424.1}.
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DR   EMBL; AHZC01000222; EHS51424.1; -; Genomic_DNA.
DR   RefSeq; WP_007602430.1; NZ_AHZC01000222.1.
DR   EnsemblBacteria; EHS51424; EHS51424; PDO_0178.
DR   PATRIC; fig|1125979.3.peg.2631; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000017669; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017669};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017669}.
FT   DOMAIN      209    337       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      424    493       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     217    224       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   519 AA;  57492 MW;  1208A5D3BCC3B077 CRC64;
     MHINSMTAGA LVNGDHAHSA LSAACSDGAG DNAEMKHNAL FERFSIRLKA QVGPDVYASW
     FGRLKLHSAS KSVVRLTVPT TFLKSWINNR YLDLISSIFQ AEDPNILKVE IMVRSASRAT
     RGPVVDERQV PADTAHPATG RKSGPQSVGQ IAASQAPASN SARSSTATPL FGSPLDSRYT
     FDGFVEGASN RVALAAAKTI AEAGAGAVRF NPLFIHSSVG LGKTHLLQAI ANAAVHSPRA
     PRVVYLTAEY FMWRFATAIR DNDALTLKDS LRNIDLLIID DMQFLQGKMI QHEFCHLLNM
     LLDSAKQVVV AADRAPWELE SLDPRVRSRL QGGVAIEMEA PDYDMRLDML KSRLDAARKD
     DGSLEIPADF LEHVARNITS SGRDLEGAFN QLVFRRSFEP NLSIERVDEL LAHLVGAGEQ
     KRVRIEDIQR IVARHYNVSR QELVSNRRTR VIVKPRQIAM YLSKTLTPRS FPEIGRRFGG
     RDHTTVLHAV RKIEDLVSED TKLSHEIELL KRLINENNA
//
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