ID H5TWD6_9ACTN Unreviewed; 2538 AA.
AC H5TWD6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Putative non-ribosomal peptide synthetase {ECO:0000313|EMBL:GAB37794.1};
GN ORFNames=GOSPT_022_01380 {ECO:0000313|EMBL:GAB37794.1};
OS Gordonia sputi NBRC 100414.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1089453 {ECO:0000313|EMBL:GAB37794.1, ECO:0000313|Proteomes:UP000005845};
RN [1] {ECO:0000313|EMBL:GAB37794.1, ECO:0000313|Proteomes:UP000005845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100414 {ECO:0000313|EMBL:GAB37794.1,
RC ECO:0000313|Proteomes:UP000005845};
RA Yoshida I., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Gordonia sputi NBRC 100414.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB37794.1}.
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DR EMBL; BAFC01000022; GAB37794.1; -; Genomic_DNA.
DR RefSeq; WP_005202867.1; NZ_BAFC01000022.1.
DR eggNOG; COG1020; Bacteria.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000005845; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 942..1022
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1991..2066
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 407..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2538 AA; 269597 MW; ECABECB4FCC823B6 CRC64;
MSAALEDVLP LTGLQEAIVY RSTAPRGADD VDPYLILADL DLTTVLPQEV DVDRLREAIA
TVTSRHATLR TSYTRRRTGE PVARVHTAVE VQLPVVDIAT LDDGLDTLRS DARTTGIALS
SPPPLRFTLV TESGRPRWLF VVAHHVALDG WSLHLMFSEI VRAYRGDALA PVRPISDYAR
WIASRGRDVG PWVEVLADVE ASTIIDIVEP TTPSVPLRAH LSVDVSAALR DVATQSSATL
NTVIQLAWAL VLADRNDSDD VVFATVVSGR DPSVPGVDEM VGMLINTIPV RVRIDPTETV
GSALTRLQRE QLALLGSHHV PPADIISAVD LGGPISSLVV FESFPRGDVR PHIEDDNDFT
ATLLVEDDPS IGLVLERRGA DPHLLDEVVA WLTMLAHSRE ELLGRLTVNP PATTPPATTT
PSESLPSESL PYVPVAQQIS DAAQRRARRT ALVSGDRRVG YRELDVLAAR TAHVLSARGI
EPESVVAVAL PRGIDMVVAI LAVARLGAVV APIDPTYPPA RIRFMLDDAA PALVLDEQTF
AEIRADAVDS PERAPHTPHP ESAAYLIYTS GSTGTPKGVV GTAAALANRI AWAAQRWDGS
VVLAKSAIAF IDGITEILGA LAAGATVAIA DDASARDPMA LVELVDRHAV DQVTAVPSLA
RAIVDLAPDS PASEKPARPE PTASIRRWIV SGEPLPDTTA ARLACAAEEV VNSYGSSEVA
GDVRTATIRF DSSDISSTPG DTAPTDVTAG VGTITVGTQV PGAGVVLLDR HLHPVSVGRP
GEVYITGVQL ARGYHRHSDW TATRFVANPA GSGDRMYRTG DRGLITPDGS LQLLGRADSQ
VKIRGTRVEL GEVEQAVLAL DGVDDTVAVA GQDHDGHTRL DVYVAGAQAP DAVPAELVAA
LPAAMIPATW TRLNSLPRTP GGKTDRRALP APTSPRTASR REPSTDLERL VVDTVADVLG
LDAADTARPS VDDNFFDLGG HSLSATRVLT RLRVATGRVV GVAEVFAHPR LADLAALFAD
DSAEITTTGV TDNAAAVPTQ RPERIPLSPA QRRLAFQSGI GDAAYTIPFA VRFDGPIDAA
QLQRALDGIV ERHETLRTRI VDDAQVVDRI DGARVLIDDH HIEPEDLDGT IDSLIGRPFE
LSADLPLRAD LLRISDASAV LLLTVHHIAA DEWSAATLFD ELAAGYNGTP VAAPQLQYAD
HTLAEIERLG TVDDPRSLVR RQLDYWRDQL ADAPAELDLP YDRPRPTDPD PVGGQVEIVI
DADVLGGLRS AVRALDATVF MAAHAAVALA LNASGAGNDI VVGTPVAGRS SASVESLIGM
FVNTLPLRTD LSGDPTLLEV LLRVRETDVA ALAAQDVPFD EIVTALAPER ALSRHPVFQT
MVQYRDPIVA PEFTGVRAEP VFPHSRTAKF DLTFEFVELA RSAGIRLRVE YAAALFDEPT
VTDLAERVSS ILRALVDAPS SHVAQLRLDR STDLPALPAP DVAPPWRSLV DFFAATARTF
ADRPAVSDGT RTLTYRELDA HSASIAARLQ RDGVRRGHSV ALILERSTDL VAAIIGVLRC
GAAYVPIDPA YPAERIASTI ADAAPTVIVD TGYLERADDS LTDTTAFDPE LAPADPAYVI
FTSGSTGKPK GVTVTHGNVV ALIDATTELF DVDENDVWTL FHSYAFDFSV WELWGPLSTG
AHLVVPDHAT TRSPADFAAL IGERGVTVLN QTPSAFFALD AADLADTEHR ETSGAVSALE
SLRYVIFGGE ALALPRLRSF ARRYPRTTLV NMYGITEITV HATYLVLDQQ IIDATTGSDV
GALLPGFTGH LLDGYLRRVP VGAVGELYLA GPQVAACYLQ RPALHATRFV ADPSGTGQVL
YRTGDLFRQT RQGALIYVGR ADTQVKIRGF RIELGEIRAA LAALPGVRDA AVLTRPGPSG
ADRILAYAVG DNVTPESLHA ESLHAALRDA LPEHEVPSAV LIVDSIPLTV NGKTDAAALP
EPEVGTAEGR TPTTEIESAL ADIFADTLGL ADPPSVDDDF FALGGDSIVS TTLVNRARRR
GIRFTPRDVF THRTVAGLGS VAEWIDDTIP AAPSNSDDAS ATRPTPIPLL PIVQRLREIG
GTIDRFNQSL VVDTPAQLDA DTLRAMVCAL LDSHEALRSS LQTVAGVLWT MQSAPPGSVD
VDDILRIVTL DRSIFDDPDA LAAAVSAESA GAAGRLSPAT GLMIAATWLT TDSPDDPIAG
RLILVIHHLA VDGVSRRILL EDLRTLWETA ATGVELQPIP TPTPLHTFAA AVTERAADPA
LLDEATHWAQ VLAPGGELVP GRLPTSGTVS DQRRHVVTLS PETSASLVSD LPTRRGVGIT
SLLLGALRVA ATRALDTGDL IVDTERHGRD AHEFGIDADL SHTVGWFTTV APIRLSATDD
IGDAIADAEN LWTAMPSAGA GFGMLRYLNP QLSAALATMS RPSVLLNYLG RFTVGGGSPW
QPSAESTALA ADPDPGLGVA YPLEIDIVCR DESSGPVVAA TFSYLPDHLD DAAVRELADA
LCAALDSLAA PAESGVNQ
//
